Unreviewed, UniProtKB/TrEMBL Q8IUB0 (Q8IUB0_HUMAN)

Names and origin

Protein names	Recommended name:     Elongation factor 1-alpha RuleBase RU004060V1
Organism	Homo sapiens (Human) EMBL AAN09722.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. RuleBase RU000325V3
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily. RuleBase RU000325V3

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	GTP-binding RuleBase RU000323V1 Nucleotide-binding
Molecular function	Elongation factor RuleBase RU000325V3
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: InterPro GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IUB0-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 03498DAC327F531C	FASTA	361	38,669
	10 20 30 40 50 60 MITGTSQADC AVLIVAAGVG EFEAGISKNG QTREHALLAY TLGVKQLIVG VNKMDSTEPP 70 80 90 100 110 120 YSQKRYEEIV KEVSTYIKKI GYNPDTVAFV PISGWNGDNM LEPSANMPWF KGWKVTRKDG 130 140 150 160 170 180 NASGTTLLEA LDCILPPTRP TDKPLRLPLQ DVYKIGGIGT VPVGRVETGV LKPGMVVTFA 190 200 210 220 230 240 PVNVTTEVKS VEMHHEALSE ALPGDNVGFN VKNVSVKDVR RGNVAGDSKN DPPMEAAGFT 250 260 270 280 290 300 AQVIILNHPG QISAGYAPVL DCHTAHIACK FAELKEKIDR RSGKKLEDGP KFLKSGDAAI 310 320 330 340 350 360 VDMVPGKPMC VESFSDYPPL GRFAVRDMRQ TVAVGVIKAV DKKAAGAGKV TKSAQKAQKA K

References

[1]	"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma." Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S. Br. J. Dermatol. 150:252-258(2004) [PubMed: 14996095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Cutaneous lymphoma EMBL AAN09722.1.
[2]	"NEDO human cDNA sequencing project." Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T. , Sugano S., Nomura N., Isogai T. Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Bladder EMBL BAF82131.1.
[3]	"Identification of a new human tumor suppressor gene." Kim J.W. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF328730 mRNA. Translation: AAN09722.1. AF322220 mRNA. Translation: AAN51932.1. AK289442 mRNA. Translation: BAF82131.1.
IPI	IPI00396485.
UniGene	Hs.520703 Hs.586423 Hs.644639 Hs.697944 Hs.708256 Hs.713109
3D structure databases
HSSP	HSSP built from PDB template 1F60 based on UniProtKB P02994.
SMR	Q8IUB0. Positions 1-342.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IUB0. 1 interaction.
Genome annotation databases
Ensembl	ENSG00000156508. Homo sapiens. [Contig view]
UCSC	uc004cch.2. human.
Organism-specific databases
HGNC	HGNC:3189. EEF1A1. HGNC:3200. EEF1AL3. HGNC:3204. EEF1AL7.
Phylogenomic databases
HOVERGEN	Q8IUB0.
Gene expression databases
ArrayExpress	Q8IUB0.
Bgee	Q8IUB0.
Family and domain databases
InterPro	IPR000795. ProtSyn_GTP_bd. IPR004539. Transl_elong_EF1A_euk/arc. IPR004161. Transl_elong_EFTu/EF1A_2. IPR004160. Transl_elong_EFTu/EF1A_C. [Graphical view]
Pfam	PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. PF03143. GTP_EFTU_D3. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
TIGRFAMs	TIGR00483. EF-1_alpha. 1 hit.
ProtoNet	Search...
Other Resources
LinkHub	Q8IUB0.

Entry information

Entry name

Q8IUB0_HUMAN

Accession

Primary (citable) accession number: Q8IUB0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	July 7, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)