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Protein

WAP four-disulfide core domain protein 8

Gene

WFDC8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI02.971.

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 8
Alternative name(s):
Putative protease inhibitor WAP8
Gene namesi
Name:WFDC8
Synonyms:C20orf170, WAP8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:16163. WFDC8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25713.

Polymorphism and mutation databases

BioMutaiWFDC8.
DMDMi126302615.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence analysisAdd
BLAST
Chaini39 – 241203WAP four-disulfide core domain protein 8PRO_0000041384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 79By similarity
Disulfide bondi58 ↔ 83By similarity
Disulfide bondi66 ↔ 78By similarity
Disulfide bondi72 ↔ 87By similarity
Disulfide bondi95 ↔ 145By similarity
Disulfide bondi104 ↔ 128By similarity
Disulfide bondi120 ↔ 141By similarity
Disulfide bondi154 ↔ 182By similarity
Disulfide bondi165 ↔ 186By similarity
Disulfide bondi169 ↔ 181By similarity
Disulfide bondi175 ↔ 190By similarity
Disulfide bondi201 ↔ 229By similarity
Disulfide bondi208 ↔ 232By similarity
Disulfide bondi216 ↔ 228By similarity
Disulfide bondi222 ↔ 236By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8IUA0.
PeptideAtlasiQ8IUA0.
PRIDEiQ8IUA0.

PTM databases

iPTMnetiQ8IUA0.
PhosphoSiteiQ8IUA0.

Expressioni

Tissue specificityi

Expressed ubiquitously, the highest levels are found in the epididymis followed by testis and trachea.

Gene expression databases

BgeeiQ8IUA0.
CleanExiHS_WFDC8.
GenevisibleiQ8IUA0. HS.

Organism-specific databases

HPAiHPA048878.

Interactioni

Protein-protein interaction databases

BioGridi124676. 1 interaction.
STRINGi9606.ENSP00000289953.

Structurei

3D structure databases

ProteinModelPortaliQ8IUA0.
SMRiQ8IUA0. Positions 93-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 9148WAP 1PROSITE-ProRule annotationAdd
BLAST
Domaini95 – 14551BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd
BLAST
Domaini147 – 19448WAP 2PROSITE-ProRule annotationAdd
BLAST
Domaini195 – 24046WAP 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.PROSITE-ProRule annotation
Contains 3 WAP domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00730000110932.
HOGENOMiHOG000134696.
HOVERGENiHBG086780.
InParanoidiQ8IUA0.
OMAiDPFQEPC.
OrthoDBiEOG7S7SG9.
PhylomeDBiQ8IUA0.
TreeFamiTF335948.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
4.10.75.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR008197. WAP_dom.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
PF00095. WAP. 3 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
PR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00217. WAP. 3 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 3 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS51390. WAP. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IUA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTVRTEGGH FPLHSPTFSW RNVAFLLLLS LALEWTSAML TKKIKHKPGL
60 70 80 90 100
CPKERLTCTT ELPDSCNTDF DCKEYQKCCF FACQKKCMDP FQEPCMLPVR
110 120 130 140 150
HGNCNHEAQR WHFDFKNYRC TPFKYRGCEG NANNFLNEDA CRTACMLIVK
160 170 180 190 200
DGQCPLFPFT ERKECPPSCH SDIDCPQTDK CCESRCGFVC ARAWTVKKGF
210 220 230 240
CPRKPLLCTK IDKPKCLQDE ECPLVEKCCS HCGLKCMDPR R
Length:241
Mass (Da):27,824
Last modified:February 20, 2007 - v2
Checksum:i3EF717C0DC1F54C2
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961M → T.
Corresponds to variant rs2272955 [ dbSNP | Ensembl ].
VAR_021910
Natural varianti137 – 1371N → S.1 Publication
Corresponds to variant rs2250860 [ dbSNP | Ensembl ].
VAR_030861

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492015 mRNA. Translation: AAN70997.1.
AF492016 mRNA. Translation: AAN70998.1.
AL591715 mRNA. Translation: CAC39449.1.
AL121778, AL031663 Genomic DNA. Translation: CAI22977.1.
AL031663, AL121778 Genomic DNA. Translation: CAI21403.1.
CH471077 Genomic DNA. Translation: EAW75828.1.
CH471077 Genomic DNA. Translation: EAW75829.1.
CCDSiCCDS13361.1.
RefSeqiNP_570966.2. NM_130896.2.
NP_852611.2. NM_181510.2.
XP_005260664.1. XM_005260607.1.
UniGeneiHs.116128.

Genome annotation databases

EnsembliENST00000289953; ENSP00000289953; ENSG00000158901.
ENST00000357199; ENSP00000361735; ENSG00000158901.
GeneIDi90199.
KEGGihsa:90199.
UCSCiuc002xow.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492015 mRNA. Translation: AAN70997.1.
AF492016 mRNA. Translation: AAN70998.1.
AL591715 mRNA. Translation: CAC39449.1.
AL121778, AL031663 Genomic DNA. Translation: CAI22977.1.
AL031663, AL121778 Genomic DNA. Translation: CAI21403.1.
CH471077 Genomic DNA. Translation: EAW75828.1.
CH471077 Genomic DNA. Translation: EAW75829.1.
CCDSiCCDS13361.1.
RefSeqiNP_570966.2. NM_130896.2.
NP_852611.2. NM_181510.2.
XP_005260664.1. XM_005260607.1.
UniGeneiHs.116128.

3D structure databases

ProteinModelPortaliQ8IUA0.
SMRiQ8IUA0. Positions 93-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124676. 1 interaction.
STRINGi9606.ENSP00000289953.

Protein family/group databases

MEROPSiI02.971.

PTM databases

iPTMnetiQ8IUA0.
PhosphoSiteiQ8IUA0.

Polymorphism and mutation databases

BioMutaiWFDC8.
DMDMi126302615.

Proteomic databases

PaxDbiQ8IUA0.
PeptideAtlasiQ8IUA0.
PRIDEiQ8IUA0.

Protocols and materials databases

DNASUi90199.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289953; ENSP00000289953; ENSG00000158901.
ENST00000357199; ENSP00000361735; ENSG00000158901.
GeneIDi90199.
KEGGihsa:90199.
UCSCiuc002xow.4. human.

Organism-specific databases

CTDi90199.
GeneCardsiWFDC8.
HGNCiHGNC:16163. WFDC8.
HPAiHPA048878.
neXtProtiNX_Q8IUA0.
PharmGKBiPA25713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4295. Eukaryota.
ENOG410XQNP. LUCA.
GeneTreeiENSGT00730000110932.
HOGENOMiHOG000134696.
HOVERGENiHBG086780.
InParanoidiQ8IUA0.
OMAiDPFQEPC.
OrthoDBiEOG7S7SG9.
PhylomeDBiQ8IUA0.
TreeFamiTF335948.

Miscellaneous databases

GenomeRNAii90199.
PROiQ8IUA0.

Gene expression databases

BgeeiQ8IUA0.
CleanExiHS_WFDC8.
GenevisibleiQ8IUA0. HS.

Family and domain databases

Gene3Di4.10.410.10. 1 hit.
4.10.75.10. 3 hits.
InterProiIPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR008197. WAP_dom.
[Graphical view]
PfamiPF00014. Kunitz_BPTI. 1 hit.
PF00095. WAP. 3 hits.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
PR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00217. WAP. 3 hits.
[Graphical view]
SUPFAMiSSF57256. SSF57256. 3 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS51390. WAP. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
    Clauss A., Lilja H., Lundwall A.
    Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-137.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiWFDC8_HUMAN
AccessioniPrimary (citable) accession number: Q8IUA0
Secondary accession number(s): E1P623, Q5TDV2, Q96A34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.