ID   LASS3_HUMAN             Reviewed;         383 AA.
AC   Q8IU89; Q8NE64; Q8NEN6;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-NOV-2009, entry version 62.
DE   RecName: Full=LAG1 longevity assurance homolog 3;
GN   Name=LASS3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in sphingolipid synthesis or its
CC       regulation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane
CC       protein (Potential).
CC   -!- SIMILARITY: Contains 1 homeobox DNA-binding domain.
CC   -!- SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.
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DR   EMBL; BC028703; AAH28703.1; -; mRNA.
DR   EMBL; BC034500; AAH34500.1; -; mRNA.
DR   EMBL; BC034970; AAH34970.1; -; mRNA.
DR   IPI; IPI00216667; -.
DR   RefSeq; NP_849164.2; -.
DR   UniGene; Hs.662371; -.
DR   PRIDE; Q8IU89; -.
DR   Ensembl; ENST00000284382; ENSP00000284382; ENSG00000154227; Homo sapiens.
DR   Ensembl; ENST00000394113; ENSP00000377672; ENSG00000154227; Homo sapiens.
DR   GeneID; 204219; -.
DR   KEGG; hsa:204219; -.
DR   UCSC; uc002bvz.1; human.
DR   CTD; 204219; -.
DR   GeneCards; GC15M098758; -.
DR   HGNC; HGNC:23752; LASS3.
DR   HPA; HPA006092; -.
DR   HPA; HPA024356; -.
DR   PharmGKB; PA134873153; -.
DR   HOGENOM; Q8IU89; -.
DR   HOVERGEN; Q8IU89; -.
DR   Reactome; REACT_602; Metabolism of lipids and lipoproteins.
DR   NextBio; 90468; -.
DR   ArrayExpress; Q8IU89; -.
DR   Bgee; Q8IU89; -.
DR   CleanEx; HS_LASS3; -.
DR   Genevestigator; Q8IU89; -.
DR   GermOnline; ENSG00000154227; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IDA:HPA.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IDA:HPA.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:transcription factor activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   InterPro; IPR001356; Homeobox.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR016439; Longevity_assurance_LAG1_LAC1.
DR   InterPro; IPR006634; TLC-dom.
DR   Pfam; PF00046; Homeobox; 1.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   PIRSF; PIRSF005225; LAG1_LAC1; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; FALSE_NEG.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Homeobox; Lipid synthesis; Membrane;
KW   Nucleus; Polymorphism; Transmembrane.
FT   CHAIN         1    383       LAG1 longevity assurance homolog 3.
FT                                /FTId=PRO_0000185511.
FT   TRANSMEM     32     52       Potential.
FT   TRANSMEM    139    159       Potential.
FT   TRANSMEM    174    194       Potential.
FT   TRANSMEM    205    225       Potential.
FT   TRANSMEM    264    284       Potential.
FT   TRANSMEM    298    318       Potential.
FT   DOMAIN      130    331       TLC.
FT   DNA_BIND     66    127       Homeobox.
FT   COMPBIAS    346    355       Poly-Glu.
FT   VARIANT     342    342       D -> G (in dbSNP:rs1023783).
FT                                /FTId=VAR_057276.
FT   VARIANT     370    370       G -> R (in dbSNP:rs2439928).
FT                                /FTId=VAR_019328.
FT   CONFLICT    144    144       Missing (in Ref. 1; AAH34500).
FT   CONFLICT    316    316       L -> R (in Ref. 1; AAH28703).
SQ   SEQUENCE   383 AA;  46217 MW;  6711189C188C8569 CRC64;
     MFWTFKEWFW LERFWLPPTI KWSDLEDHDG LVFVKPSHLY VTIPYAFLLL IIRRVFEKFV
     ASPLAKSFGI KETVRKVTPN TVLENFFKHS TRQPLQTDIY GLAKKCNLTE RQVERWFRSR
     RNQERPSRLK KFQEACWRFA FYLMITVAGI AFLYDKPWLY DLWEVWNGYP KQPLLPSQYW
     YYILEMSFYW SLLFRLGFDV KRKDFLAHII HHLAAISLMS FSWCANYIRS GTLVMIVHDV
     ADIWLESAKM FSYAGWTQTC NTLFFIFSTI FFISRLIVFP FWILYCTLIL PMYHLEPFFS
     YIFLNLQLMI LQVLHLYWGY YILKMLNRCI FMKSIQDVRS DDEDYEEEEE EEEEEATKGK
     EMDCLKNGLG AERHLIPNGQ HGH
//