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Q8IU82

- Q8IU82_HUMAN

UniProt

Q8IU82 - Q8IU82_HUMAN

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Protein
Submitted name:

Breast and ovarian cancer susceptibility protein

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell aging Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  5. double-strand break repair via homologous recombination Source: Ensembl
  6. female gonad development Source: Ensembl
  7. hemopoiesis Source: Ensembl
  8. inner cell mass cell proliferation Source: Ensembl
  9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  10. male meiosis I Source: Ensembl
  11. oocyte maturation Source: Ensembl
  12. positive regulation of mitotic cell cycle Source: Ensembl
  13. regulation of cytokinesis Source: Ensembl
  14. replication fork protection Source: Ensembl
  15. response to gamma radiation Source: Ensembl
  16. response to UV-C Source: Ensembl
  17. response to X-ray Source: Ensembl
  18. spermatogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast and ovarian cancer susceptibility proteinImported
Gene namesi
Name:BRCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8IU82.
ExpressionAtlasiQ8IU82. baseline and differential.

Family & Domainsi

Family and domain databases

InterProiIPR015525. BRCA2.
[Graphical view]
PANTHERiPTHR11289. PTHR11289. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q8IU82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30 
GRQTPKHISE SLGAEVDPDM SWSSSLATPP TLSSTVLI
Length:38
Mass (Da):3,996
Last modified:March 1, 2003 - v1
Checksum:i7D88F08D3EB6889A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei38 – 381Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507087 Genomic DNA. Translation: AAN61434.1.
AF507088 Genomic DNA. Translation: AAN61435.1.
AF507089 Genomic DNA. Translation: AAN61436.1.
AF507090 Genomic DNA. Translation: AAN61437.1.
UniGeneiHs.34012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF507087 Genomic DNA. Translation: AAN61434.1 .
AF507088 Genomic DNA. Translation: AAN61435.1 .
AF507089 Genomic DNA. Translation: AAN61436.1 .
AF507090 Genomic DNA. Translation: AAN61437.1 .
UniGenei Hs.34012.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q8IU82.
ExpressionAtlasi Q8IU82. baseline and differential.

Family and domain databases

InterProi IPR015525. BRCA2.
[Graphical view ]
PANTHERi PTHR11289. PTHR11289. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "BRCA2 germline mutations in Indian breast cancer families."
    Valarmathi M.T., Agarwal A., Deo S.S.V., Shukla N.K., Das S.N.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8IU82_HUMAN
AccessioniPrimary (citable) accession number: Q8IU82
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.