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Protein

Interferon regulatory factor 2-binding protein 1

Gene

IRF2BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri503 – 550RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi6.3.2.19. 2681.
SIGNORiQ8IU81.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein 1
Short name:
IRF-2-binding protein 1
Short name:
IRF-2BP1
Alternative name(s):
Probable E3 ubiquitin-protein ligase IRF2BP1 (EC:6.3.2.-)
Gene namesi
Name:IRF2BP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:21728. IRF2BP1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170604.
PharmGKBiPA134987893.

Polymorphism and mutation databases

BioMutaiIRF2BP1.
DMDMi74727955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003287291 – 584Interferon regulatory factor 2-binding protein 1Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei177Omega-N-methylarginineCombined sources1
Modified residuei186PhosphoserineCombined sources1
Modified residuei371PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei453PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ8IU81.
MaxQBiQ8IU81.
PaxDbiQ8IU81.
PeptideAtlasiQ8IU81.
PRIDEiQ8IU81.

PTM databases

iPTMnetiQ8IU81.
PhosphoSitePlusiQ8IU81.

Expressioni

Gene expression databases

BgeeiENSG00000170604.
CleanExiHS_IRF2BP1.
GenevisibleiQ8IU81. HS.

Organism-specific databases

HPAiHPA042164.
HPA049480.

Interactioni

Subunit structurei

Interacts with IRF2. Part of a corepressor complex containing IRF2 and IRF2BP2. Interacts with JDP2.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
JDP2Q8WYK24EBI-6115514,EBI-1248415

Protein-protein interaction databases

BioGridi117576. 22 interactors.
IntActiQ8IU81. 4 interactors.
MINTiMINT-1194891.
STRINGi9606.ENSP00000307265.

Structurei

3D structure databases

ProteinModelPortaliQ8IU81.
SMRiQ8IU81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni503 – 550Cys-richAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili197 – 217Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the IRF2BP family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri503 – 550RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
GeneTreeiENSGT00390000005089.
HOGENOMiHOG000049069.
HOVERGENiHBG108364.
InParanoidiQ8IU81.
OMAiVSGPDRY.
OrthoDBiEOG091G040R.
PhylomeDBiQ8IU81.
TreeFamiTF317075.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
IPR018957. Znf_C3HC4_RING-type.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IU81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVQASRRQ WCYLCDLPKM PWAMVWDFSE AVCRGCVNFE GADRIELLID
60 70 80 90 100
AARQLKRSHV LPEGRSPGPP ALKHPATKDL AAAAAQGPQL PPPQAQPQPS
110 120 130 140 150
GTGGGVSGQD RYDRATSSGR LPLPSPALEY TLGSRLANGL GREEAVAEGA
160 170 180 190 200
RRALLGSMPG LMPPGLLAAA VSGLGSRGLT LAPGLSPARP LFGSDFEKEK
210 220 230 240 250
QQRNADCLAE LNEAMRGRAE EWHGRPKAVR EQLLALSACA PFNVRFKKDH
260 270 280 290 300
GLVGRVFAFD ATARPPGYEF ELKLFTEYPC GSGNVYAGVL AVARQMFHDA
310 320 330 340 350
LREPGKALAS SGFKYLEYER RHGSGEWRQL GELLTDGVRS FREPAPAEAL
360 370 380 390 400
PQQYPEPAPA ALCGPPPRAP SRNLAPTPRR RKASPEPEGE AAGKMTTEEQ
410 420 430 440 450
QQRHWVAPGG PYSAETPGVP SPIAALKNVA EALGHSPKDP GGGGGPVRAG
460 470 480 490 500
GASPAASSTA QPPTQHRLVA RNGEAEVSPT AGAEAVSGGG SGTGATPGAP
510 520 530 540 550
LCCTLCRERL EDTHFVQCPS VPGHKFCFPC SREFIKAQGP AGEVYCPSGD
560 570 580
KCPLVGSSVP WAFMQGEIAT ILAGDIKVKK ERDP
Length:584
Mass (Da):61,688
Last modified:March 1, 2003 - v1
Checksum:i7E160D86C155E1D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti80L → P in BAD97342 (Ref. 2) Curated1
Sequence conflicti250H → R in BAD97342 (Ref. 2) Curated1
Sequence conflicti381R → C in AAH78181 (PubMed:15489334).Curated1
Sequence conflicti577K → E in BAD97342 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04250224M → I.1 PublicationCorresponds to variant rs11550349dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278022 mRNA. Translation: AAP78943.1.
AK223622 mRNA. Translation: BAD97342.1.
CH471126 Genomic DNA. Translation: EAW57396.1.
BC005834 mRNA. Translation: AAH05834.2.
BC038222 mRNA. Translation: AAH38222.1.
BC039002 mRNA. Translation: AAH39002.1.
BC078181 mRNA. Translation: AAH78181.1.
AL080159 mRNA. Translation: CAB45750.1.
CCDSiCCDS12678.1.
PIRiT12543.
RefSeqiNP_056464.1. NM_015649.2.
UniGeneiHs.515477.

Genome annotation databases

EnsembliENST00000302165; ENSP00000307265; ENSG00000170604.
GeneIDi26145.
KEGGihsa:26145.
UCSCiuc002pds.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY278022 mRNA. Translation: AAP78943.1.
AK223622 mRNA. Translation: BAD97342.1.
CH471126 Genomic DNA. Translation: EAW57396.1.
BC005834 mRNA. Translation: AAH05834.2.
BC038222 mRNA. Translation: AAH38222.1.
BC039002 mRNA. Translation: AAH39002.1.
BC078181 mRNA. Translation: AAH78181.1.
AL080159 mRNA. Translation: CAB45750.1.
CCDSiCCDS12678.1.
PIRiT12543.
RefSeqiNP_056464.1. NM_015649.2.
UniGeneiHs.515477.

3D structure databases

ProteinModelPortaliQ8IU81.
SMRiQ8IU81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117576. 22 interactors.
IntActiQ8IU81. 4 interactors.
MINTiMINT-1194891.
STRINGi9606.ENSP00000307265.

PTM databases

iPTMnetiQ8IU81.
PhosphoSitePlusiQ8IU81.

Polymorphism and mutation databases

BioMutaiIRF2BP1.
DMDMi74727955.

Proteomic databases

EPDiQ8IU81.
MaxQBiQ8IU81.
PaxDbiQ8IU81.
PeptideAtlasiQ8IU81.
PRIDEiQ8IU81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302165; ENSP00000307265; ENSG00000170604.
GeneIDi26145.
KEGGihsa:26145.
UCSCiuc002pds.2. human.

Organism-specific databases

CTDi26145.
GeneCardsiIRF2BP1.
HGNCiHGNC:21728. IRF2BP1.
HPAiHPA042164.
HPA049480.
MIMi615331. gene.
neXtProtiNX_Q8IU81.
OpenTargetsiENSG00000170604.
PharmGKBiPA134987893.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
GeneTreeiENSGT00390000005089.
HOGENOMiHOG000049069.
HOVERGENiHBG108364.
InParanoidiQ8IU81.
OMAiVSGPDRY.
OrthoDBiEOG091G040R.
PhylomeDBiQ8IU81.
TreeFamiTF317075.

Enzyme and pathway databases

BRENDAi6.3.2.19. 2681.
SIGNORiQ8IU81.

Miscellaneous databases

GenomeRNAii26145.
PROiQ8IU81.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170604.
CleanExiHS_IRF2BP1.
GenevisibleiQ8IU81. HS.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
IPR018957. Znf_C3HC4_RING-type.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiI2BP1_HUMAN
AccessioniPrimary (citable) accession number: Q8IU81
Secondary accession number(s): Q53EL7
, Q6DC95, Q9BRZ9, Q9Y4P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.