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Q8IU77

- Q8IU77_HUMAN

UniProt

Q8IU77 - Q8IU77_HUMAN

Protein
Submitted name:

Breast and ovarian cancer susceptibility protein

Gene

BRCA2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
  1. Functioni

    GO - Biological processi

    1. brain development Source: Ensembl
    2. cell aging Source: Ensembl
    3. chromosome organization Source: Ensembl
    4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
    5. double-strand break repair via homologous recombination Source: Ensembl
    6. female gonad development Source: Ensembl
    7. hemopoiesis Source: Ensembl
    8. inner cell mass cell proliferation Source: Ensembl
    9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
    10. male meiosis I Source: Ensembl
    11. oocyte maturation Source: Ensembl
    12. positive regulation of mitotic cell cycle Source: Ensembl
    13. regulation of cytokinesis Source: Ensembl
    14. replication fork protection Source: Ensembl
    15. response to gamma radiation Source: Ensembl
    16. response to UV-C Source: Ensembl
    17. response to X-ray Source: Ensembl
    18. spermatogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Breast and ovarian cancer susceptibility proteinImported
    Gene namesi
    Name:BRCA2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ8IU77.
    BgeeiQ8IU77.

    Sequencei

    Sequence statusi: Fragment.

    Q8IU77-1 [UniParc]FASTAAdd to Basket

    « Hide

    RNVPNSRHKS LRTVKTKMDQ ADDVSCPLLN SCLSE                   35
    Length:35
    Mass (Da):3,943
    Last modified:March 1, 2003 - v1
    Checksum:i8ED0CCB929AA82FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei35 – 351Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF507079 Genomic DNA. Translation: AAN61426.1.
    AF507080 Genomic DNA. Translation: AAN61427.1.
    AF507081 Genomic DNA. Translation: AAN61428.1.
    AF507082 Genomic DNA. Translation: AAN61429.1.
    AF507083 Genomic DNA. Translation: AAN61430.1.
    AF507084 Genomic DNA. Translation: AAN61431.1.
    AF507085 Genomic DNA. Translation: AAN61432.1.
    AF507086 Genomic DNA. Translation: AAN61433.1.
    UniGeneiHs.34012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF507079 Genomic DNA. Translation: AAN61426.1 .
    AF507080 Genomic DNA. Translation: AAN61427.1 .
    AF507081 Genomic DNA. Translation: AAN61428.1 .
    AF507082 Genomic DNA. Translation: AAN61429.1 .
    AF507083 Genomic DNA. Translation: AAN61430.1 .
    AF507084 Genomic DNA. Translation: AAN61431.1 .
    AF507085 Genomic DNA. Translation: AAN61432.1 .
    AF507086 Genomic DNA. Translation: AAN61433.1 .
    UniGenei Hs.34012.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q8IU77.
    Bgeei Q8IU77.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "BRCA2 germline mutations in Indian breast cancer families."
      Valarmathi M.T., Agarwal A., Deo S.S.V., Shukla N.K., Das S.N.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8IU77_HUMAN
    AccessioniPrimary (citable) accession number: Q8IU77
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.