Q8IU71 (Q8IU71_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Integrin alpha-4 subunit EMBL CAD53328.1

Gene names

Name:

IA4 EMBL CAD53328.1

Organism

Homo sapiens (Human) EMBL CAD53328.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	174 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU003762.
Sequence similarities	Belongs to the integrin alpha chain family. RuleBase RU003762

Ontologies

Keywords
Biological process	Cell adhesion RuleBase RU003762
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003762
Molecular function	Integrin RuleBase RU003762 EMBL CAD53328.1 Receptor RuleBase RU003762
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW integrin-mediated signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL CAD53328.1
	Non-terminal residue	174	1	EMBL CAD53328.1

Sequences

	Sequence		Length	Mass (Da)
	Q8IU71 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 9D1493E5E1333239	FASTA	174	20,057
	10 20 30 40 50 60 RVCALEQQKS AMQTLKGIVQ FLSKTDKRLL YCIKADPHCL NFLCNFGKME SGKEASVHIQ 70 80 90 100 110 120 LEGRPSILEM DETSALKFEI RATGFPEPNP RVIELNKDEN VAHVLLEGLH HQRPKRYFTI 130 140 150 160 170 VIISSSLLLG LIVLLLISYV MWKAGFFKRQ YKSILQEENR RDSWSYINSK SNDD

References

[1]	"Frequencies of alpha4 A3061G variants and identification of three new variants of the human integrin alpha4-subunit." Heymann G.A., Kiesewetter H., Salama A. Mol. Immunol. 39:855-860(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 3311C EMBL CAD53329.1 and 3311T EMBL CAD53328.1. Tissue: Peripheral blood EMBL CAD53328.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ510248 mRNA. Translation: CAD53328.1. AJ510249 mRNA. Translation: CAD53329.1.
IPI	IPI00916041.
UniGene	Hs.440955.
3D structure databases
ProteinModelPortal	Q8IU71.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
H-InvDB	HIX0161873.
Phylogenomic databases
HOVERGEN	HBG060852.
Family and domain databases
InterPro	IPR018184. Integrin_alpha_C_CS. [Graphical view]
Pfam	PF00357. Integrin_alpha. 1 hit. [Graphical view]
PROSITE	PS00242. INTEGRIN_ALPHA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CD82. human.

Entry information

Entry name

Q8IU71_HUMAN

Accession

Primary (citable) accession number: Q8IU71

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.