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Q8IU64

- Q8IU64_HUMAN

UniProt

Q8IU64 - Q8IU64_HUMAN

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Protein
Submitted name:

Breast and ovarian cancer susceptibility protein

Gene
BRCA2
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Biological processi

  1. brain development Source: Ensembl
  2. cell aging Source: Ensembl
  3. chromosome organization Source: Ensembl
  4. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
  5. double-strand break repair via homologous recombination Source: Ensembl
  6. female gonad development Source: Ensembl
  7. hemopoiesis Source: Ensembl
  8. inner cell mass cell proliferation Source: Ensembl
  9. intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
  10. male meiosis I Source: Ensembl
  11. oocyte maturation Source: Ensembl
  12. positive regulation of mitotic cell cycle Source: Ensembl
  13. regulation of cytokinesis Source: Ensembl
  14. replication fork protection Source: Ensembl
  15. response to gamma radiation Source: Ensembl
  16. response to UV-C Source: Ensembl
  17. response to X-ray Source: Ensembl
  18. spermatogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast and ovarian cancer susceptibility proteinImported
Submitted name:
Breast cancer susceptibility protein BRCA2Imported
Gene namesi
Name:BRCA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiQ8IU64.
BgeeiQ8IU64.

Sequencei

Sequence statusi: Fragment.

Q8IU64-1 [UniParc]FASTAAdd to Basket

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MPIGSKERPT FFEIFKTRCN KA                                 22
Length:22
Mass (Da):2,601
Last modified:March 1, 2003 - v1
Checksum:iB91816F3DDB545C6
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei22 – 221Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151039 Genomic DNA. Translation: AAN28944.1.
AF489725 Genomic DNA. Translation: AAN61409.1.
AF489726 Genomic DNA. Translation: AAN61410.1.
AF489727 Genomic DNA. Translation: AAN61411.1.
AF489728 Genomic DNA. Translation: AAN61412.1.
AF489729 Genomic DNA. Translation: AAN61413.1.
AF489730 Genomic DNA. Translation: AAN61414.1.
AF489731 Genomic DNA. Translation: AAN61415.1.
AF489732 Genomic DNA. Translation: AAN61416.1.
AF489733 Genomic DNA. Translation: AAN61417.1.
AF489734 Genomic DNA. Translation: AAN61418.1.
AF489735 Genomic DNA. Translation: AAN61419.1.
AF489736 Genomic DNA. Translation: AAN61420.1.
AF489737 Genomic DNA. Translation: AAN61421.1.
AF489738 Genomic DNA. Translation: AAN61422.1.
UniGeneiHs.34012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151039 Genomic DNA. Translation: AAN28944.1 .
AF489725 Genomic DNA. Translation: AAN61409.1 .
AF489726 Genomic DNA. Translation: AAN61410.1 .
AF489727 Genomic DNA. Translation: AAN61411.1 .
AF489728 Genomic DNA. Translation: AAN61412.1 .
AF489729 Genomic DNA. Translation: AAN61413.1 .
AF489730 Genomic DNA. Translation: AAN61414.1 .
AF489731 Genomic DNA. Translation: AAN61415.1 .
AF489732 Genomic DNA. Translation: AAN61416.1 .
AF489733 Genomic DNA. Translation: AAN61417.1 .
AF489734 Genomic DNA. Translation: AAN61418.1 .
AF489735 Genomic DNA. Translation: AAN61419.1 .
AF489736 Genomic DNA. Translation: AAN61420.1 .
AF489737 Genomic DNA. Translation: AAN61421.1 .
AF489738 Genomic DNA. Translation: AAN61422.1 .
UniGenei Hs.34012.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

H-InvDB HIX0037331.

Gene expression databases

ArrayExpressi Q8IU64.
Bgeei Q8IU64.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Study of BRCA2 gene polymorphisms in sporadic breast cancer of Indian origin."
    Bairwa N.K., Saha A., Bamezai R.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families."
    Valarmathi M.T., Sawhney M., Deo S.S.V., Shukla N.K., Das S.N.
    Hum. Mutat. 23:205-205(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IRCHF10AImported, IRCHF10BImported, IRCHS13AImported, IRCHS13BImported, IRCHS3AImported, IRCHS3BImported, IRCHS4AImported, IRCHS4BImported, IRCHS6AImported, IRCHS6BImported, IRCHS7AImported, IRCHS7BImported, IRCHS9AImported and IRCHS9BImported.

Entry informationi

Entry nameiQ8IU64_HUMAN
AccessioniPrimary (citable) accession number: Q8IU64
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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