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Q8IU57

- INLR1_HUMAN

UniProt

Q8IU57 - INLR1_HUMAN

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Protein
Interferon lambda receptor 1
Gene
IFNLR1, IL28RA, LICR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
  2. defense response to virus Source: UniProtKB
  3. mucosal immune response Source: UniProtKB
  4. negative regulation of cell proliferation Source: UniProtKB
  5. regulation of defense response to virus by host Source: UniProtKB
  6. response to type III interferon Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SignaLinkiQ8IU57.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda receptor 1
Short name:
IFN-lambda receptor 1
Short name:
IFN-lambda-R1
Alternative name(s):
Cytokine receptor class-II member 12
Cytokine receptor family 2 member 12
Short name:
CRF2-12
Interleukin-28 receptor subunit alpha
Short name:
IL-28 receptor subunit alpha
Short name:
IL-28R-alpha
Short name:
IL-28RA
Likely interleukin or cytokine receptor 2
Short name:
LICR2
Gene namesi
Name:IFNLR1
Synonyms:IL28RA, LICR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:18584. IFNLR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 228208Extracellular Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Topological domaini250 – 520271Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. interleukin-28 receptor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134984880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 520500Interferon lambda receptor 1
PRO_0000011019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)1 Publication
Glycosylationi36 – 361N-linked (GlcNAc...)1 Publication
Disulfide bondi74 ↔ 821 Publication
Disulfide bondi86 ↔ 1501 Publication
Glycosylationi142 – 1421N-linked (GlcNAc...)1 Publication
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi195 ↔ 2171 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IU57.
PRIDEiQ8IU57.

PTM databases

PhosphoSiteiQ8IU57.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

ArrayExpressiQ8IU57.
BgeeiQ8IU57.
CleanExiHS_IL28RA.
GenevestigatoriQ8IU57.

Organism-specific databases

HPAiHPA017319.

Interactioni

Subunit structurei

Heterodimer with IL10RB.2 Publications

Protein-protein interaction databases

BioGridi127873. 1 interaction.
IntActiQ8IU57. 1 interaction.
STRINGi9606.ENSP00000327824.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 358
Beta strandi38 – 447
Beta strandi54 – 607
Helixi63 – 653
Beta strandi68 – 703
Helixi72 – 743
Beta strandi79 – 835
Beta strandi98 – 1047
Helixi119 – 1224
Beta strandi129 – 1357
Beta strandi138 – 1447
Beta strandi156 – 1649
Beta strandi170 – 1723
Beta strandi180 – 1856
Beta strandi192 – 20918
Beta strandi216 – 2194

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OG4X-ray2.16B19-226[»]
3OG6X-ray2.10B19-226[»]
ProteinModelPortaliQ8IU57.
SMRiQ8IU57. Positions 24-223.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 126101Fibronectin type-III
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46166.
HOVERGENiHBG052069.
InParanoidiQ8IU57.
KOiK05140.
OMAiPWFQRAK.
OrthoDBiEOG78H3T9.
PhylomeDBiQ8IU57.
TreeFamiTF336003.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF01108. Tissue_fac. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8IU57-1) [UniParc]FASTAAdd to Basket

Also known as: IL-28R-alpha-v1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP    50
QDVTYFVAYQ SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV 100
RTVSPSSKSP WVESEYLDYL FEVEPAPPVL VLTQTEEILS ANATYQLPPC 150
MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ PVQITLQPAA SEHHCLSART 200
IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL VIAAGGVIWK 250
TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR 300
GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL 350
GQEHQAPGHS EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR 400
AGSSGYLAEK GPGQGPGGDG HQESLPPPEF SKDSGFLEEL PEDNLSSWAT 450
WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP EEEEEARESE IEDSDAGSWG 500
AESTQRTEDR GRTLGHYMAR 520
Length:520
Mass (Da):57,653
Last modified:March 1, 2003 - v1
Checksum:iCEDAEE57F85D69AC
GO
Isoform 2 (identifier: Q8IU57-2) [UniParc]FASTAAdd to Basket

Also known as: IL-28R-alpha-v2

The sequence of this isoform differs from the canonical sequence as follows:
     268-296: Missing.

Show »
Length:491
Mass (Da):54,415
Checksum:i78C48C86DC3866AA
GO
Isoform 3 (identifier: Q8IU57-3) [UniParc]FASTAAdd to Basket

Also known as: IL-28R-alpha-v3

The sequence of this isoform differs from the canonical sequence as follows:
     171-211: TLFPVTPHGQ...YTFSVPKYSK → VGSSFPAPRL...LLQEVFPVHS
     212-244: Missing.
     245-520: Missing.

Show »
Length:211
Mass (Da):23,689
Checksum:i5EA84B77134CDAB0
GO
Isoform 4 (identifier: Q8IU57-4) [UniParc]FASTAAdd to Basket

Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     224-244: EANWAFLVLPSLLILLLVIAA → GLFWTHTPCGNLSAQQTRVRE
     245-520: Missing.

Show »
Length:244
Mass (Da):27,536
Checksum:iA6F3310C13FCC083
GO

Sequence cautioni

The sequence BAD18707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei171 – 21141TLFPV…PKYSK → VGSSFPAPRLGPLLHPFLLR FFSPSQPAPAPLLQEVFPVH S in isoform 3.
VSP_011888Add
BLAST
Alternative sequencei212 – 24433Missing in isoform 3.
VSP_011889Add
BLAST
Alternative sequencei224 – 24421EANWA…LVIAA → GLFWTHTPCGNLSAQQTRVR E in isoform 4.
VSP_011891Add
BLAST
Alternative sequencei245 – 520276Missing in isoform 3 and isoform 4.
VSP_011892Add
BLAST
Alternative sequencei268 – 29629Missing in isoform 2.
VSP_011890Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ534330 mRNA. Translation: CAD58829.1.
AJ534331 mRNA. Translation: CAD58830.1.
AY129151 mRNA. Translation: AAN28266.1.
AY129152 mRNA. Translation: AAN28267.1.
AY129153 mRNA. Translation: AAN28268.1.
AF439325 mRNA. Translation: AAN63632.1.
AK160364 mRNA. Translation: BAD18707.1. Different initiation.
AL590683 Genomic DNA. Translation: CAH70118.1.
AL590683 Genomic DNA. Translation: CAH70119.1.
AL590683 Genomic DNA. Translation: CAH70120.1.
AL590683 Genomic DNA. Translation: CAH70121.1.
CH471134 Genomic DNA. Translation: EAW95114.1.
CH471134 Genomic DNA. Translation: EAW95115.1.
CH471134 Genomic DNA. Translation: EAW95117.1.
CH471134 Genomic DNA. Translation: EAW95118.1.
BC140872 mRNA. Translation: AAI40873.1.
CCDSiCCDS248.1. [Q8IU57-1]
CCDS249.1. [Q8IU57-2]
CCDS250.1. [Q8IU57-4]
RefSeqiNP_734464.1. NM_170743.3. [Q8IU57-1]
NP_775087.1. NM_173064.2. [Q8IU57-2]
NP_775088.1. NM_173065.2. [Q8IU57-4]
UniGeneiHs.221375.

Genome annotation databases

EnsembliENST00000327535; ENSP00000327824; ENSG00000185436. [Q8IU57-1]
ENST00000327575; ENSP00000328994; ENSG00000185436. [Q8IU57-4]
ENST00000374418; ENSP00000363539; ENSG00000185436. [Q8IU57-3]
ENST00000374421; ENSP00000363542; ENSG00000185436. [Q8IU57-2]
GeneIDi163702.
KEGGihsa:163702.
UCSCiuc001bir.3. human. [Q8IU57-2]
uc001bis.3. human. [Q8IU57-1]
uc001bit.3. human. [Q8IU57-4]
uc001biv.3. human. [Q8IU57-3]

Polymorphism databases

DMDMi55976528.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ534330 mRNA. Translation: CAD58829.1 .
AJ534331 mRNA. Translation: CAD58830.1 .
AY129151 mRNA. Translation: AAN28266.1 .
AY129152 mRNA. Translation: AAN28267.1 .
AY129153 mRNA. Translation: AAN28268.1 .
AF439325 mRNA. Translation: AAN63632.1 .
AK160364 mRNA. Translation: BAD18707.1 . Different initiation.
AL590683 Genomic DNA. Translation: CAH70118.1 .
AL590683 Genomic DNA. Translation: CAH70119.1 .
AL590683 Genomic DNA. Translation: CAH70120.1 .
AL590683 Genomic DNA. Translation: CAH70121.1 .
CH471134 Genomic DNA. Translation: EAW95114.1 .
CH471134 Genomic DNA. Translation: EAW95115.1 .
CH471134 Genomic DNA. Translation: EAW95117.1 .
CH471134 Genomic DNA. Translation: EAW95118.1 .
BC140872 mRNA. Translation: AAI40873.1 .
CCDSi CCDS248.1. [Q8IU57-1 ]
CCDS249.1. [Q8IU57-2 ]
CCDS250.1. [Q8IU57-4 ]
RefSeqi NP_734464.1. NM_170743.3. [Q8IU57-1 ]
NP_775087.1. NM_173064.2. [Q8IU57-2 ]
NP_775088.1. NM_173065.2. [Q8IU57-4 ]
UniGenei Hs.221375.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3OG4 X-ray 2.16 B 19-226 [» ]
3OG6 X-ray 2.10 B 19-226 [» ]
ProteinModelPortali Q8IU57.
SMRi Q8IU57. Positions 24-223.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127873. 1 interaction.
IntActi Q8IU57. 1 interaction.
STRINGi 9606.ENSP00000327824.

PTM databases

PhosphoSitei Q8IU57.

Polymorphism databases

DMDMi 55976528.

Proteomic databases

PaxDbi Q8IU57.
PRIDEi Q8IU57.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000327535 ; ENSP00000327824 ; ENSG00000185436 . [Q8IU57-1 ]
ENST00000327575 ; ENSP00000328994 ; ENSG00000185436 . [Q8IU57-4 ]
ENST00000374418 ; ENSP00000363539 ; ENSG00000185436 . [Q8IU57-3 ]
ENST00000374421 ; ENSP00000363542 ; ENSG00000185436 . [Q8IU57-2 ]
GeneIDi 163702.
KEGGi hsa:163702.
UCSCi uc001bir.3. human. [Q8IU57-2 ]
uc001bis.3. human. [Q8IU57-1 ]
uc001bit.3. human. [Q8IU57-4 ]
uc001biv.3. human. [Q8IU57-3 ]

Organism-specific databases

CTDi 163702.
GeneCardsi GC01M024481.
HGNCi HGNC:18584. IFNLR1.
HPAi HPA017319.
MIMi 607404. gene.
neXtProti NX_Q8IU57.
PharmGKBi PA134984880.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46166.
HOVERGENi HBG052069.
InParanoidi Q8IU57.
KOi K05140.
OMAi PWFQRAK.
OrthoDBi EOG78H3T9.
PhylomeDBi Q8IU57.
TreeFami TF336003.

Enzyme and pathway databases

SignaLinki Q8IU57.

Miscellaneous databases

ChiTaRSi IL28RA. human.
GeneWikii Interleukin_28_receptor,_alpha_subunit.
GenomeRNAii 163702.
NextBioi 88380.
PROi Q8IU57.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8IU57.
Bgeei Q8IU57.
CleanExi HS_IL28RA.
Genevestigatori Q8IU57.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF01108. Tissue_fac. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3."
    Dumoutier L., Lejeune D., Hor S., Fickenscher H., Renauld J.-C.
    Biochem. J. 370:391-396(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBUNIT.
  3. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
    Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
    Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBUNIT.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Spleen.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1."
    Miknis Z.J., Magracheva E., Li W., Zdanov A., Kotenko S.V., Wlodawer A.
    J. Mol. Biol. 404:650-664(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 19-226 IN COMPLEX WITH IFNL1, GLYCOSYLATION AT ASN-29; ASN-36 AND ASN-142, DISULFIDE BONDS.

Entry informationi

Entry nameiINLR1_HUMAN
AccessioniPrimary (citable) accession number: Q8IU57
Secondary accession number(s): Q5VTX5
, Q5VTX7, Q5VTX8, Q6ZML8, Q8IV66, Q8IZI7, Q8IZI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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