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Reviewed, UniProtKB/Swiss-Prot Q8IU57 (I28RA_HUMAN)

Last modified July 7, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Interleukin-28 receptor alpha chain
      Short name=IL-28R-alpha
      Short name=IL-28RA
Alternative name(s):
    Cytokine receptor class-II member 12
    Cytokine receptor family 2 member 12
      Short name=CRF2-12
    Interferon lambda receptor 1
      Short name=IFN-lambda R1
    Likely interleukin or cytokine receptor 2
Gene names
Name: IL28RA
Synonyms: IFNLR1, LICR2
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

The IL28RA/IL10RB dimer is a receptor for IL28A, IL28B and IL29. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Ref.1 Ref.2 Ref.3

Subunit structure

Heterodimer with IL10RB. Ref.2 Ref.3

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Widely expressed. Ref.2 Ref.3

Sequence similarities

Belongs to the type II cytokine receptor family.

Contains 1 fibronectin type-III domain.

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Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processnegative regulation of cell proliferation Ref.2

Non-traceable author statement. Source: UniProtKB

regulation of defense response to virus by host Ref.2

Inferred from direct assay. Source: UniProtKB

   Cellular componentinterleukin-28 receptor complex Ref.2

Inferred from direct assay. Source: UniProtKB

   Molecular functionprotein binding Ref.2 Ref.3

Inferred from physical interaction. Source: UniProtKB

receptor activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

LSM8O957771EBI-373215,EBI-347779

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Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8IU57-1)

Also known as: IL-28R-alpha-v1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8IU57-2)

Also known as: IL-28R-alpha-v2;

The sequence of this isoform differs from the canonical sequence as follows:
     268-296: Missing.
Isoform 3 (identifier: Q8IU57-3)

Also known as: IL-28R-alpha-v3;

The sequence of this isoform differs from the canonical sequence as follows:
     171-211: TLFPVTPHGQ...YTFSVPKYSK → VGSSFPAPRL...LLQEVFPVHS
     212-244: Missing.
     245-520: Missing.
Isoform 4 (identifier: Q8IU57-4)

Also known as: Secreted;

The sequence of this isoform differs from the canonical sequence as follows:
     224-244: EANWAFLVLPSLLILLLVIAA → GLFWTHTPCGNLSAQQTRVRE
     245-520: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 520500Interleukin-28 receptor alpha chain
PRO_0000011019

Regions

Topological domain21 – 228208Extracellular Potential
Transmembrane229 – 24921 Potential
Topological domain250 – 520271Cytoplasmic Potential
Domain23 – 12098Fibronectin type-III

Amino acid modifications

Glycosylation291N-linked (GlcNAc...) Potential
Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1691N-linked (GlcNAc...) Potential
Disulfide bond74 ↔ 82 By similarity

Natural variations

Alternative sequence171 – 21141TLFPV…PKYSK → VGSSFPAPRLGPLLHPFLLR FFSPSQPAPAPLLQEVFPVH S in isoform 3.
VSP_011888
Alternative sequence212 – 24433Missing in isoform 3.
VSP_011889
Alternative sequence224 – 24421EANWA…LVIAA → GLFWTHTPCGNLSAQQTRVR E in isoform 4.
VSP_011891
Alternative sequence245 – 520276Missing in isoform 3 and isoform 4.
VSP_011892
Alternative sequence268 – 29629Missing in isoform 2.
VSP_011890

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Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (IL-28R-alpha-v1) [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CEDAEE57F85D69AC

FASTA52057,653
        10         20         30         40         50         60 
MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP QDVTYFVAYQ 

        70         80         90        100        110        120 
SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV RTVSPSSKSP WVESEYLDYL 

       130        140        150        160        170        180 
FEVEPAPPVL VLTQTEEILS ANATYQLPPC MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ 

       190        200        210        220        230        240 
PVQITLQPAA SEHHCLSART IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL 

       250        260        270        280        290        300 
VIAAGGVIWK TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR 

       310        320        330        340        350        360 
GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL GQEHQAPGHS 

       370        380        390        400        410        420 
EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR AGSSGYLAEK GPGQGPGGDG 

       430        440        450        460        470        480 
HQESLPPPEF SKDSGFLEEL PEDNLSSWAT WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP 

       490        500        510        520 
EEEEEARESE IEDSDAGSWG AESTQRTEDR GRTLGHYMAR

« Hide

Isoform 2 (IL-28R-alpha-v2).

Checksum: 78C48C86DC3866AA
Show »

FASTA49154,415
Isoform 3 (IL-28R-alpha-v3).

Checksum: 5EA84B77134CDAB0
Show »

FASTA21123,689
Isoform 4 (Secreted).

Checksum: A6F3310C13FCC083
Show »

FASTA24427,536

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References

« Hide 'large scale' references
[1]"Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3."
Dumoutier L., Lejeune D., Hor S., Fickenscher H., Renauld J.-C.
Biochem. J. 370:391-396(2003) [PubMed: 12521379] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), FUNCTION.
[2]"IL-28, IL-29 and their class II cytokine receptor IL-28R."
Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S., Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J., Ostrander C., Dong D., Shin J., Presnell S., Fox B., Haldeman B., Cooper E., Taft D. expand/collapse author list , Gilbert T., Grant F.J., Tackett M., Krivan W., McKnight G., Clegg C., Foster D., Klucher K.M.
Nat. Immunol. 4:63-68(2003) [PubMed: 12469119] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBUNIT.
[3]"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
Nat. Immunol. 4:69-77(2003) [PubMed: 12483210] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBUNIT.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Spleen.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AJ534330 mRNA. Translation: CAD58829.1.
AY129151 mRNA. Translation: AAN28266.1.
AY129152 mRNA. Translation: AAN28267.1.
AY129153 mRNA. Translation: AAN28268.1.
AF439325 mRNA. Translation: AAN63632.1.
AK160364 mRNA. Translation: BAD18707.1. Different initiation.
IPIIPI00216651.
IPI00216892.
IPI00218008.
IPI00383608.
RefSeqNP_734464.1.
NP_775087.1.
UniGeneHs.221375

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

IntActQ8IU57. 1 interaction.

Proteomic databases

PRIDEQ8IU57.

Genome annotation databases

EnsemblENSG00000185436. Homo sapiens. [Contig view]
GeneID163702.
KEGGhsa:163702.
UCSCuc001bir.1. human.
uc001bis.1. human.
uc001biv.2. human.

Organism-specific databases

GeneCardsGC01M024353.
H-InvDBHIX0028608.
HGNCHGNC:18584. IL28RA.
HPAHPA017319.
MIM607404. gene.
PharmGKBPA134984880.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ8IU57.
HOVERGENQ8IU57.
OMAQ8IU57. LGHYMAR.

Gene expression databases

ArrayExpressQ8IU57.
BgeeQ8IU57.
CleanExHS_IL28RA.
GermOnlineENSG00000185436. Homo sapiens.

Family and domain databases

InterProIPR008957. Fibronectin_typ-III-like_fold.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 1 hit.
PROSITEPS50853. FN3. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio88380.
SOURCESearch...

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Entry information

Entry nameI28RA_HUMAN
AccessionPrimary (citable) accession number: Q8IU57
Secondary accession number(s): Q6ZML8, Q8IZI7, Q8IZI8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: July 7, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents