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Q8IU57

- INLR1_HUMAN

UniProt

Q8IU57 - INLR1_HUMAN

Protein

Interferon lambda receptor 1

Gene

IFNLR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.3 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. defense response to virus Source: UniProtKB
    3. mucosal immune response Source: UniProtKB
    4. negative regulation of cell proliferation Source: UniProtKB
    5. regulation of defense response to virus by host Source: UniProtKB
    6. response to type III interferon Source: UniProtKB

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    SignaLinkiQ8IU57.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon lambda receptor 1
    Short name:
    IFN-lambda receptor 1
    Short name:
    IFN-lambda-R1
    Alternative name(s):
    Cytokine receptor class-II member 12
    Cytokine receptor family 2 member 12
    Short name:
    CRF2-12
    Interleukin-28 receptor subunit alpha
    Short name:
    IL-28 receptor subunit alpha
    Short name:
    IL-28R-alpha
    Short name:
    IL-28RA
    Likely interleukin or cytokine receptor 2
    Short name:
    LICR2
    Gene namesi
    Name:IFNLR1
    Synonyms:IL28RA, LICR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:18584. IFNLR1.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. interleukin-28 receptor complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134984880.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 520500Interferon lambda receptor 1PRO_0000011019Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi29 – 291N-linked (GlcNAc...)1 Publication
    Glycosylationi36 – 361N-linked (GlcNAc...)1 Publication
    Disulfide bondi74 ↔ 821 Publication
    Disulfide bondi86 ↔ 1501 Publication
    Glycosylationi142 – 1421N-linked (GlcNAc...)1 Publication
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi195 ↔ 2171 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8IU57.
    PRIDEiQ8IU57.

    PTM databases

    PhosphoSiteiQ8IU57.

    Expressioni

    Tissue specificityi

    Widely expressed.2 Publications

    Gene expression databases

    ArrayExpressiQ8IU57.
    BgeeiQ8IU57.
    CleanExiHS_IL28RA.
    GenevestigatoriQ8IU57.

    Organism-specific databases

    HPAiHPA017319.

    Interactioni

    Subunit structurei

    Heterodimer with IL10RB.3 Publications

    Protein-protein interaction databases

    BioGridi127873. 1 interaction.
    IntActiQ8IU57. 1 interaction.
    STRINGi9606.ENSP00000327824.

    Structurei

    Secondary structure

    1
    520
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 358
    Beta strandi38 – 447
    Beta strandi54 – 607
    Helixi63 – 653
    Beta strandi68 – 703
    Helixi72 – 743
    Beta strandi79 – 835
    Beta strandi98 – 1047
    Helixi119 – 1224
    Beta strandi129 – 1357
    Beta strandi138 – 1447
    Beta strandi156 – 1649
    Beta strandi170 – 1723
    Beta strandi180 – 1856
    Beta strandi192 – 20918
    Beta strandi216 – 2194

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3OG4X-ray2.16B19-226[»]
    3OG6X-ray2.10B19-226[»]
    ProteinModelPortaliQ8IU57.
    SMRiQ8IU57. Positions 24-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 228208ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini250 – 520271CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 126101Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the type II cytokine receptor family.Curated
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46166.
    HOVERGENiHBG052069.
    InParanoidiQ8IU57.
    KOiK05140.
    OMAiPWFQRAK.
    OrthoDBiEOG78H3T9.
    PhylomeDBiQ8IU57.
    TreeFamiTF336003.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF01108. Tissue_fac. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    PROSITEiPS50853. FN3. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8IU57-1) [UniParc]FASTAAdd to Basket

    Also known as: IL-28R-alpha-v1

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP    50
    QDVTYFVAYQ SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV 100
    RTVSPSSKSP WVESEYLDYL FEVEPAPPVL VLTQTEEILS ANATYQLPPC 150
    MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ PVQITLQPAA SEHHCLSART 200
    IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL VIAAGGVIWK 250
    TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR 300
    GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL 350
    GQEHQAPGHS EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR 400
    AGSSGYLAEK GPGQGPGGDG HQESLPPPEF SKDSGFLEEL PEDNLSSWAT 450
    WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP EEEEEARESE IEDSDAGSWG 500
    AESTQRTEDR GRTLGHYMAR 520
    Length:520
    Mass (Da):57,653
    Last modified:March 1, 2003 - v1
    Checksum:iCEDAEE57F85D69AC
    GO
    Isoform 2 (identifier: Q8IU57-2) [UniParc]FASTAAdd to Basket

    Also known as: IL-28R-alpha-v2

    The sequence of this isoform differs from the canonical sequence as follows:
         268-296: Missing.

    Show »
    Length:491
    Mass (Da):54,415
    Checksum:i78C48C86DC3866AA
    GO
    Isoform 3 (identifier: Q8IU57-3) [UniParc]FASTAAdd to Basket

    Also known as: IL-28R-alpha-v3

    The sequence of this isoform differs from the canonical sequence as follows:
         171-211: TLFPVTPHGQ...YTFSVPKYSK → VGSSFPAPRL...LLQEVFPVHS
         212-244: Missing.
         245-520: Missing.

    Show »
    Length:211
    Mass (Da):23,689
    Checksum:i5EA84B77134CDAB0
    GO
    Isoform 4 (identifier: Q8IU57-4) [UniParc]FASTAAdd to Basket

    Also known as: Secreted

    The sequence of this isoform differs from the canonical sequence as follows:
         224-244: EANWAFLVLPSLLILLLVIAA → GLFWTHTPCGNLSAQQTRVRE
         245-520: Missing.

    Show »
    Length:244
    Mass (Da):27,536
    Checksum:iA6F3310C13FCC083
    GO

    Sequence cautioni

    The sequence BAD18707.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei171 – 21141TLFPV…PKYSK → VGSSFPAPRLGPLLHPFLLR FFSPSQPAPAPLLQEVFPVH S in isoform 3. 1 PublicationVSP_011888Add
    BLAST
    Alternative sequencei212 – 24433Missing in isoform 3. 1 PublicationVSP_011889Add
    BLAST
    Alternative sequencei224 – 24421EANWA…LVIAA → GLFWTHTPCGNLSAQQTRVR E in isoform 4. 1 PublicationVSP_011891Add
    BLAST
    Alternative sequencei245 – 520276Missing in isoform 3 and isoform 4. 2 PublicationsVSP_011892Add
    BLAST
    Alternative sequencei268 – 29629Missing in isoform 2. 1 PublicationVSP_011890Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ534330 mRNA. Translation: CAD58829.1.
    AJ534331 mRNA. Translation: CAD58830.1.
    AY129151 mRNA. Translation: AAN28266.1.
    AY129152 mRNA. Translation: AAN28267.1.
    AY129153 mRNA. Translation: AAN28268.1.
    AF439325 mRNA. Translation: AAN63632.1.
    AK160364 mRNA. Translation: BAD18707.1. Different initiation.
    AL590683 Genomic DNA. Translation: CAH70118.1.
    AL590683 Genomic DNA. Translation: CAH70119.1.
    AL590683 Genomic DNA. Translation: CAH70120.1.
    AL590683 Genomic DNA. Translation: CAH70121.1.
    CH471134 Genomic DNA. Translation: EAW95114.1.
    CH471134 Genomic DNA. Translation: EAW95115.1.
    CH471134 Genomic DNA. Translation: EAW95117.1.
    CH471134 Genomic DNA. Translation: EAW95118.1.
    BC140872 mRNA. Translation: AAI40873.1.
    CCDSiCCDS248.1. [Q8IU57-1]
    CCDS249.1. [Q8IU57-2]
    CCDS250.1. [Q8IU57-4]
    RefSeqiNP_734464.1. NM_170743.3. [Q8IU57-1]
    NP_775087.1. NM_173064.2. [Q8IU57-2]
    NP_775088.1. NM_173065.2. [Q8IU57-4]
    UniGeneiHs.221375.

    Genome annotation databases

    EnsembliENST00000327535; ENSP00000327824; ENSG00000185436. [Q8IU57-1]
    ENST00000327575; ENSP00000328994; ENSG00000185436. [Q8IU57-4]
    ENST00000374418; ENSP00000363539; ENSG00000185436. [Q8IU57-3]
    ENST00000374421; ENSP00000363542; ENSG00000185436. [Q8IU57-2]
    GeneIDi163702.
    KEGGihsa:163702.
    UCSCiuc001bir.3. human. [Q8IU57-2]
    uc001bis.3. human. [Q8IU57-1]
    uc001bit.3. human. [Q8IU57-4]
    uc001biv.3. human. [Q8IU57-3]

    Polymorphism databases

    DMDMi55976528.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ534330 mRNA. Translation: CAD58829.1 .
    AJ534331 mRNA. Translation: CAD58830.1 .
    AY129151 mRNA. Translation: AAN28266.1 .
    AY129152 mRNA. Translation: AAN28267.1 .
    AY129153 mRNA. Translation: AAN28268.1 .
    AF439325 mRNA. Translation: AAN63632.1 .
    AK160364 mRNA. Translation: BAD18707.1 . Different initiation.
    AL590683 Genomic DNA. Translation: CAH70118.1 .
    AL590683 Genomic DNA. Translation: CAH70119.1 .
    AL590683 Genomic DNA. Translation: CAH70120.1 .
    AL590683 Genomic DNA. Translation: CAH70121.1 .
    CH471134 Genomic DNA. Translation: EAW95114.1 .
    CH471134 Genomic DNA. Translation: EAW95115.1 .
    CH471134 Genomic DNA. Translation: EAW95117.1 .
    CH471134 Genomic DNA. Translation: EAW95118.1 .
    BC140872 mRNA. Translation: AAI40873.1 .
    CCDSi CCDS248.1. [Q8IU57-1 ]
    CCDS249.1. [Q8IU57-2 ]
    CCDS250.1. [Q8IU57-4 ]
    RefSeqi NP_734464.1. NM_170743.3. [Q8IU57-1 ]
    NP_775087.1. NM_173064.2. [Q8IU57-2 ]
    NP_775088.1. NM_173065.2. [Q8IU57-4 ]
    UniGenei Hs.221375.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3OG4 X-ray 2.16 B 19-226 [» ]
    3OG6 X-ray 2.10 B 19-226 [» ]
    ProteinModelPortali Q8IU57.
    SMRi Q8IU57. Positions 24-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127873. 1 interaction.
    IntActi Q8IU57. 1 interaction.
    STRINGi 9606.ENSP00000327824.

    PTM databases

    PhosphoSitei Q8IU57.

    Polymorphism databases

    DMDMi 55976528.

    Proteomic databases

    PaxDbi Q8IU57.
    PRIDEi Q8IU57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000327535 ; ENSP00000327824 ; ENSG00000185436 . [Q8IU57-1 ]
    ENST00000327575 ; ENSP00000328994 ; ENSG00000185436 . [Q8IU57-4 ]
    ENST00000374418 ; ENSP00000363539 ; ENSG00000185436 . [Q8IU57-3 ]
    ENST00000374421 ; ENSP00000363542 ; ENSG00000185436 . [Q8IU57-2 ]
    GeneIDi 163702.
    KEGGi hsa:163702.
    UCSCi uc001bir.3. human. [Q8IU57-2 ]
    uc001bis.3. human. [Q8IU57-1 ]
    uc001bit.3. human. [Q8IU57-4 ]
    uc001biv.3. human. [Q8IU57-3 ]

    Organism-specific databases

    CTDi 163702.
    GeneCardsi GC01M024481.
    HGNCi HGNC:18584. IFNLR1.
    HPAi HPA017319.
    MIMi 607404. gene.
    neXtProti NX_Q8IU57.
    PharmGKBi PA134984880.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46166.
    HOVERGENi HBG052069.
    InParanoidi Q8IU57.
    KOi K05140.
    OMAi PWFQRAK.
    OrthoDBi EOG78H3T9.
    PhylomeDBi Q8IU57.
    TreeFami TF336003.

    Enzyme and pathway databases

    SignaLinki Q8IU57.

    Miscellaneous databases

    ChiTaRSi IL28RA. human.
    GeneWikii Interleukin_28_receptor,_alpha_subunit.
    GenomeRNAii 163702.
    NextBioi 88380.
    PROi Q8IU57.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8IU57.
    Bgeei Q8IU57.
    CleanExi HS_IL28RA.
    Genevestigatori Q8IU57.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF01108. Tissue_fac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    PROSITEi PS50853. FN3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3."
      Dumoutier L., Lejeune D., Hor S., Fickenscher H., Renauld J.-C.
      Biochem. J. 370:391-396(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, TISSUE SPECIFICITY, SUBUNIT.
    3. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
      Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
      Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, SUBUNIT.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Spleen.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1."
      Miknis Z.J., Magracheva E., Li W., Zdanov A., Kotenko S.V., Wlodawer A.
      J. Mol. Biol. 404:650-664(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 19-226 IN COMPLEX WITH IFNL1, GLYCOSYLATION AT ASN-29; ASN-36 AND ASN-142, DISULFIDE BONDS.

    Entry informationi

    Entry nameiINLR1_HUMAN
    AccessioniPrimary (citable) accession number: Q8IU57
    Secondary accession number(s): Q5VTX5
    , Q5VTX7, Q5VTX8, Q6ZML8, Q8IV66, Q8IZI7, Q8IZI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3