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Protein

Interferon lambda-1

Gene

IFNL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

GO - Molecular functioni

  • interleukin-28 receptor binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • defense response to virus Source: UniProtKB
  • innate immune response Source: GO_Central
  • JAK-STAT cascade Source: InterPro
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of interleukin-13 production Source: UniProtKB
  • negative regulation of interleukin-5 production Source: UniProtKB
  • negative regulation of memory T cell differentiation Source: UniProtKB
  • negative regulation of T cell differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of type 2 immune response Source: UniProtKB
  • positive regulation of immune response Source: UniProtKB
  • positive regulation of interferon-gamma production Source: UniProtKB
  • positive regulation of JAK-STAT cascade Source: UniProtKB
  • positive regulation of MHC class I biosynthetic process Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

SignaLinkiQ8IU54.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon lambda-1
Short name:
IFN-lambda-1
Alternative name(s):
Cytokine Zcyto21
Interleukin-29
Short name:
IL-29
Gene namesi
Name:IFNL1
Synonyms:IL29, ZCYTO21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18363. IFNL1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • interleukin-28 receptor complex Source: UniProtKB
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899000.

Polymorphism and mutation databases

BioMutaiIFNL1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 200181Interferon lambda-1PRO_0000015511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi68 ↔ 1641 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8IU54.
PRIDEiQ8IU54.

Expressioni

Inductioni

By viral infections or double-stranded RNA.

Gene expression databases

BgeeiQ8IU54.
CleanExiHS_IL29.
GenevisibleiQ8IU54. HS.

Interactioni

GO - Molecular functioni

  • interleukin-28 receptor binding Source: UniProtKB
  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi129396. 2 interactions.
IntActiQ8IU54. 1 interaction.
STRINGi9606.ENSP00000329991.

Structurei

Secondary structure

1
200
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi44 – 6118Combined sources
Helixi79 – 813Combined sources
Helixi84 – 863Combined sources
Helixi87 – 10519Combined sources
Turni108 – 1103Combined sources
Helixi111 – 12919Combined sources
Helixi145 – 15915Combined sources
Helixi162 – 17817Combined sources
Helixi180 – 1867Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OG4X-ray2.16A23-200[»]
3OG6X-ray2.10A20-200[»]
ProteinModelPortaliQ8IU54.
SMRiQ8IU54. Positions 41-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lambda interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0IH. Eukaryota.
ENOG410ZDRD. LUCA.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ8IU54.
KOiK05447.
OMAiSFKKARD.
OrthoDBiEOG7F24V6.
PhylomeDBiQ8IU54.
TreeFamiTF336172.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8IU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAWTVVLV TLVLGLAVAG PVPTSKPTTT GKGCHIGRFK SLSPQELASF
60 70 80 90 100
KKARDALEES LKLKNWSCSS PVFPGNWDLR LLQVRERPVA LEAELALTLK
110 120 130 140 150
VLEAAAGPAL EDVLDQPLHT LHHILSQLQA CIQPQPTAGP RPRGRLHHWL
160 170 180 190 200
HRLQEAPKKE SAGCLEASVT FNLFRLLTRD LKYVADGNLC LRTSTHPEST
Length:200
Mass (Da):21,898
Last modified:March 1, 2003 - v1
Checksum:iD4433B9462DCB4A1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881N → D.1 Publication
Corresponds to variant rs30461 [ dbSNP | Ensembl ].
VAR_024506

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129150 mRNA. Translation: AAN28265.1.
AY184372 mRNA. Translation: AAN86125.1.
AY336716 mRNA. Translation: AAR24511.1.
AC011445 Genomic DNA. No translation available.
BC074985 mRNA. Translation: AAH74985.1.
BC126183 mRNA. Translation: AAI26184.1.
BC117482 mRNA. Translation: AAI17483.1.
CCDSiCCDS12531.1.
RefSeqiNP_742152.1. NM_172140.1.
UniGeneiHs.406745.

Genome annotation databases

EnsembliENST00000333625; ENSP00000329991; ENSG00000182393.
GeneIDi282618.
KEGGihsa:282618.
UCSCiuc002okv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-29 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY129150 mRNA. Translation: AAN28265.1.
AY184372 mRNA. Translation: AAN86125.1.
AY336716 mRNA. Translation: AAR24511.1.
AC011445 Genomic DNA. No translation available.
BC074985 mRNA. Translation: AAH74985.1.
BC126183 mRNA. Translation: AAI26184.1.
BC117482 mRNA. Translation: AAI17483.1.
CCDSiCCDS12531.1.
RefSeqiNP_742152.1. NM_172140.1.
UniGeneiHs.406745.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OG4X-ray2.16A23-200[»]
3OG6X-ray2.10A20-200[»]
ProteinModelPortaliQ8IU54.
SMRiQ8IU54. Positions 41-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129396. 2 interactions.
IntActiQ8IU54. 1 interaction.
STRINGi9606.ENSP00000329991.

Polymorphism and mutation databases

BioMutaiIFNL1.

Proteomic databases

PaxDbiQ8IU54.
PRIDEiQ8IU54.

Protocols and materials databases

DNASUi282618.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333625; ENSP00000329991; ENSG00000182393.
GeneIDi282618.
KEGGihsa:282618.
UCSCiuc002okv.4. human.

Organism-specific databases

CTDi282618.
GeneCardsiIFNL1.
HGNCiHGNC:18363. IFNL1.
MIMi607403. gene.
neXtProtiNX_Q8IU54.
PharmGKBiPA134899000.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0IH. Eukaryota.
ENOG410ZDRD. LUCA.
GeneTreeiENSGT00390000014310.
HOGENOMiHOG000232074.
HOVERGENiHBG052108.
InParanoidiQ8IU54.
KOiK05447.
OMAiSFKKARD.
OrthoDBiEOG7F24V6.
PhylomeDBiQ8IU54.
TreeFamiTF336172.

Enzyme and pathway databases

SignaLinkiQ8IU54.

Miscellaneous databases

GeneWikiiInterleukin_29.
GenomeRNAii282618.
NextBioi93474.
PROiQ8IU54.
SOURCEiSearch...

Gene expression databases

BgeeiQ8IU54.
CleanExiHS_IL29.
GenevisibleiQ8IU54. HS.

Family and domain databases

InterProiIPR029177. INF_lambda.
[Graphical view]
PfamiPF15177. IL28A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex."
    Kotenko S.V., Gallagher G., Baurin V.V., Lewis-Antes A., Shen M., Shah N.K., Langer J.A., Sheikh F., Dickensheets H., Donnelly R.P.
    Nat. Immunol. 4:69-77(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Construction of mammalian cell expression vector of human interleukin (IL)-28A, IL-28B and IL-29 gene from activated peripheral blood mononuclear cell and analysis of its sequence."
    Li M., He S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-188.
  6. "Interferon-lambda: a new addition to an old family."
    Donnelly R.P., Kotenko S.V.
    J. Interferon Cytokine Res. 30:555-564(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Interferon-lambda in the context of viral infections: production, response and therapeutic implications."
    Hermant P., Michiels T.
    J. Innate Immun. 6:563-574(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  8. "Crystal structure of human interferon-lambda1 in complex with its high-affinity receptor interferon-lambdaR1."
    Miknis Z.J., Magracheva E., Li W., Zdanov A., Kotenko S.V., Wlodawer A.
    J. Mol. Biol. 404:650-664(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-200 IN COMPLEX WITH IFNLR1, DISULFIDE BOND.

Entry informationi

Entry nameiIFNL1_HUMAN
AccessioniPrimary (citable) accession number: Q8IU54
Secondary accession number(s): A0AV25, Q17R34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2003
Last modified: April 13, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.