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Protein

Protein CASC2, isoforms 1/2

Gene

CASC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CASC2, isoforms 1/2
Alternative name(s):
Cancer susceptibility candidate gene 2 protein isoforms 1/2
Gene namesi
Name:CASC2
Synonyms:C10orf5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:22933. CASC2.

Pathology & Biotechi

Organism-specific databases

DisGeNETi255082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003229871 – 76Protein CASC2, isoforms 1/2Add BLAST76

Proteomic databases

PRIDEiQ8IU53.

Expressioni

Gene expression databases

CleanExiHS_CASC2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8IU53-1) [UniParc]FASTAAdd to basket
Also known as: CASC2c

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTRGLMLL GPGPVAGPRD VGTCRGRQME IQKHKDNKKL PQGIIIVFRL
60 70
QTHTTPQIYT QLKGKLRKFF KEPYSE
Length:76
Mass (Da):8,607
Last modified:March 1, 2003 - v1
Checksum:iF155AAABEBACD37D
GO
Isoform 2 (identifier: Q8IU53-2) [UniParc]FASTAAdd to basket
Also known as: CASC2b

The sequence of this isoform differs from the canonical sequence as follows:
     43-63: Missing.

Show »
Length:55
Mass (Da):6,154
Checksum:i79647046D148EDDB
GO
Isoform 3 (identifier: Q6XLA1-1) [UniParc]FASTAAdd to basket
Also known as: CASC2a
The sequence of this isoform can be found in the external entry Q6XLA1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:102
Mass (Da):11,902
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5R → L in BC112326 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03197843 – 63Missing in isoform 2. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ535620 mRNA. Translation: CAD59605.1.
AJ535621 mRNA. Translation: CAD59606.1.
AJ535622 mRNA. Translation: CAD59607.1.
CH471066 Genomic DNA. Translation: EAW49421.1.
AC022395 Genomic DNA. No translation available.
BC112326 mRNA. No translation available.
UniGeneiHs.89387.

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiCASC2_HUMAN
AccessioniPrimary (citable) accession number: Q8IU53
Secondary accession number(s): Q2M1K1, Q8IUI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot