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Protein
Submitted name:

Lysozyme

Gene
N/A
Organism
Ruditapes philippinarum (Japanese littleneck clam) (Venerupis philippinarum)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841N-acetyl-D-glucosamineCombined sources
Binding sitei92 – 921N-acetyl-D-glucosamineCombined sources
Binding sitei119 – 1191N-acetyl-D-glucosamineCombined sources

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.
MEROPSiS81.001.

Names & Taxonomyi

Protein namesi
Submitted name:
LysozymeImported
OrganismiRuditapes philippinarum (Japanese littleneck clam) (Venerupis philippinarum)Imported
Taxonomic identifieri129788 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaHeteroconchiaEuheterodontaVeneroidaVeneroideaVeneridaeRuditapes

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 98Combined sources
Disulfide bondi24 ↔ 130Combined sources
Disulfide bondi26 ↔ 33Combined sources
Disulfide bondi38 ↔ 47Combined sources
Disulfide bondi60 ↔ 80Combined sources
Disulfide bondi70 ↔ 76Combined sources
Disulfide bondi94 ↔ 112Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DQAX-ray1.60A/B12-134[»]
ProteinModelPortaliQ8IU26.
SMRiQ8IU26. Positions 12-134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IU26.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 597N-acetyl-D-glucosamine bindingCombined sources
Regioni105 – 1073N-acetyl-D-glucosamine bindingCombined sources

Family and domain databases

InterProiIPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IU26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METVSVEEGL DFAPGMVSQK CLLCMCKLES GGCKPIGCRM DVGSLSCGYF
60 70 80 90 100
QIKQPYWIDC GKPGKDWKSC SNDINCSSKC VQQYMKRYAT HYRCPLNCEG
110 120 130
FAREHNGGPN GCHSSRTLKY WELLQKIPGC KGVKFS
Length:136
Mass (Da):15,198
Last modified:March 1, 2003 - v1
Checksum:i78E0918E7A563876
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091383 mRNA. Translation: BAC15553.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB091383 mRNA. Translation: BAC15553.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DQAX-ray1.60A/B12-134[»]
ProteinModelPortaliQ8IU26.
SMRiQ8IU26. Positions 12-134.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH22. Glycoside Hydrolase Family 22.
MEROPSiS81.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ8IU26.

Family and domain databases

InterProiIPR008597. Destabilase.
IPR023346. Lysozyme-like_dom.
[Graphical view]
PANTHERiPTHR11195. PTHR11195. 1 hit.
PfamiPF05497. Destabilase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete cDNA sequence of Tapes japonica lysozyme."
    Takeshita K., Ueda T., Imoto T.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal structure of Tapes japonica Lysozyme with substrate analogue: structural basis of the catalytic mechanism and manifestation of its chitinase activity accompanied by quaternary structural change."
    Goto T., Abe Y., Kakuta Y., Takeshita K., Imoto T., Ueda T.
    J. Biol. Chem. 282:27459-27467(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 12-134 IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE, DISULFIDE BONDS.

Entry informationi

Entry nameiQ8IU26_RUDPH
AccessioniPrimary (citable) accession number: Q8IU26
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.