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Q8ISC9 (CSW_DROSI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase corkscrew

EC=3.1.3.48
Gene names
Name:csw
OrganismDrosophila simulans (Fruit fly)
Taxonomic identifier7240 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length555 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 555›555Tyrosine-protein phosphatase corkscrew
PRO_0000094851

Regions

Domain85 – 355271Tyrosine-protein phosphatase
Region11 – 10393PTPase insert (Cys/Ser-rich)
Region293 – 2997Substrate binding By similarity
Compositional bias447 – 48135Asn-rich
Compositional bias507 – 5104Poly-Gln

Sites

Active site2931Phosphocysteine intermediate By similarity
Binding site2551Substrate By similarity
Binding site3401Substrate By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
Q8ISC9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 801534C03AE9DCFD

FASTA55559,841
        10         20         30         40         50         60 
LPTDGDLYNM SSSSESLNSS VPSCPACTAA QTQRNCSNCQ LMNKTCVQCA VKSAILPYSN 

        70         80         90        100        110        120 
CATCSRKSDS LSKHKRSESS ASSSPSSGSG SGPGSSGTSG VSSVNGPGTP TNLTSGTAGC 

       130        140        150        160        170        180 
LAGLLKRHSN DSSGAVSISM AERERERERE MFKTYIATQG CLLTQQVNTV TDFWNMVWQE 

       190        200        210        220        230        240 
NTRVIVMTTK EYERGKEKCA RYWPDEGRSE QFGHARIQCV SENSTSDYTL REFLVSWRDQ 

       250        260        270        280        290        300 
PARRIFHYHF QVWPDHGVPA DPGCVLNFLQ DVNTRQSHLA QAGEKPGPIC VHCSAGIGRT 

       310        320        330        340        350        360 
GTFIVIDMIL DQIVRNGLDT EIDIQRTIQM VRSQRSGLVQ TEAQYKFVYY AVQHYIQTLI 

       370        380        390        400        410        420 
ARKRAEEQSL QVGREYTNIK YTGEIGNDSQ RSPLPPAISS ISLVPSKTPL TPTSADLGTG 

       430        440        450        460        470        480 
MGLSMGVGMG VGNKHASKQQ PPLPVVNCNN NNNGIGNSSC SNGGGSSNTS SSNGSSNGNI 

       490        500        510        520        530        540 
NALLGGIGLG LGGNMRKSNF YSDSLKQQQQ REEQAPAGAG KMQQPAPPLR PRPGILKLLT 

       550 
SPVIFQQNSK TFPKT 

« Hide

References

[1]"Contrasting selection pressures on components of the Ras-mediated signal transduction pathway in Drosophila."
Riley R.M., Jin W., Gibson G.
Mol. Ecol. 12:1315-1323(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SIM31.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY135142 Genomic DNA. Translation: AAN17645.1.

3D structure databases

ProteinModelPortalQ8ISC9.
SMRQ8ISC9. Positions 152-360.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

FlyBaseFBgn0063985. Dsim\csw.

Phylogenomic databases

OrthoDBEOG7T4MS6.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCSW_DROSI
AccessionPrimary (citable) accession number: Q8ISC9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase