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Protein

Glutathione peroxidase

Gene

PHGPx

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei74UniRule annotation1

GO - Molecular functioni

  • glutathione peroxidase activity Source: FlyBase
  • peroxidase activity Source: FlyBase

GO - Biological processi

  • response to lipid hydroperoxide Source: FlyBase
  • response to oxidative stress Source: FlyBase

Keywordsi

Molecular functionOxidoreductase, PeroxidaseUniRule annotationImported

Protein family/group databases

PeroxiBasei5639. DmGPx02-C.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione peroxidaseUniRule annotation
Gene namesi
Name:PHGPxImported
Synonyms:anon-WO0257455.17Imported, Dmel\CG12013Imported, DmGPxImported, DmPHGPxImported, GPxImported, GTPxImported, GTPx-1Imported, Gtpx-1Imported, PGTPxImported, phGpxImported
ORF Names:CG12013Imported, Dmel_CG12013Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0035438. PHGPx.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 24HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • endomembrane system Source: FlyBase
  • Golgi apparatus Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: FlyBase

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0035438.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0072932.

Structurei

3D structure databases

SMRiQ8IRD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00840000130500.
KOiK00432.
OMAiPMDISKD.
OrthoDBiEOG091G0OJG.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
InterProiView protein in InterPro
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiView protein in Pfam
PF00255. GSHPx. 1 hit.
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IRD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRSIVHFF LGSVAIALGS YIYFTMQIDM SANGDYKNAA SIYEFTVKDT
60 70 80 90 100
HGNDVSLEKY KGKVVLVVNI ASKCGLTKNN YEKLTDLKEK YGERGLVILN
110 120 130 140 150
FPCNQFGSQM PEADGEAMVC HLRDSKADIG EVFAKVDVNG DNAAPLYKYL
160 170 180 190
KAKQTGTLGS GIKWNFTKFL VNKEGVPINR YAPTTDPMDI AKDIEKLL
Length:198
Mass (Da):21,867
Last modified:March 1, 2003 - v1
Checksum:iC1034ADF8709BD1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAN11561.1.
BT011331 mRNA. Translation: AAR96123.1.
RefSeqiNP_728868.1. NM_168024.2.
UniGeneiDm.835.

Genome annotation databases

EnsemblMetazoaiFBtr0073066; FBpp0072930; FBgn0035438.
GeneIDi38413.
KEGGidme:Dmel_CG12013.
UCSCiCG12013-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAN11561.1.
BT011331 mRNA. Translation: AAR96123.1.
RefSeqiNP_728868.1. NM_168024.2.
UniGeneiDm.835.

3D structure databases

SMRiQ8IRD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0072932.

Protein family/group databases

PeroxiBasei5639. DmGPx02-C.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073066; FBpp0072930; FBgn0035438.
GeneIDi38413.
KEGGidme:Dmel_CG12013.
UCSCiCG12013-RA. d. melanogaster.

Organism-specific databases

CTDi38413.
FlyBaseiFBgn0035438. PHGPx.

Phylogenomic databases

eggNOGiKOG1651. Eukaryota.
COG0386. LUCA.
GeneTreeiENSGT00840000130500.
KOiK00432.
OMAiPMDISKD.
OrthoDBiEOG091G0OJG.

Miscellaneous databases

GenomeRNAii38413.

Gene expression databases

BgeeiFBgn0035438.

Family and domain databases

CDDicd00340. GSH_Peroxidase. 1 hit.
InterProiView protein in InterPro
IPR000889. Glutathione_peroxidase.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiView protein in Pfam
PF00255. GSHPx. 1 hit.
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IRD4_DROME
AccessioniPrimary (citable) accession number: Q8IRD4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.