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Q8IR69

- Q8IR69_DROME

UniProt

Q8IR69 - Q8IR69_DROME

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Protein
Submitted name:

HDAC4, isoform B

Gene

HDAC4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi764 – 7641ZincUniRule annotation
Metal bindingi766 – 7661ZincUniRule annotation
Metal bindingi772 – 7721ZincUniRule annotation
Metal bindingi845 – 8451ZincUniRule annotation
Active sitei897 – 8971UniRule annotation

GO - Molecular functioni

  1. histone deacetylase activity Source: FlyBase

GO - Biological processi

  1. histone deacetylation Source: GOC
  2. long-term memory Source: FlyBase
  3. memory Source: FlyBase
  4. regulation of transcription, DNA-templated Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotationImported

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
HDAC4, isoform BImported (EC:3.5.1.-Imported)
Submitted name:
HDAC4, isoform HImported (EC:3.5.1.-Imported)
Gene namesi
Name:HDAC4Imported
ORF Names:CG1770Imported, Dmel_CG1770Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0041210. HDAC4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. histone deacetylase complex Source: InterPro
  3. nucleus Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ8IR69.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
KOiK11406.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q8IR69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELEHKLQLE HKYQFAVNSH GAFQELRNES MVTAAAAAVA QEQHRQQLHQ
60 70 80 90 100
QQQQHQQQQQ QQQHQQQQQQ QQARGRDGMK LKQNCSANAS PEVKQILNCF
110 120 130 140 150
ILSRKSQAAA SNGTTTTSPY RNRGVVKSSS GESLPAGTVT SAHPYKIPQP
160 170 180 190 200
PPSLLKYESD FPLRKTASEP NLLKIRLKQS VIERKARIGG PAGARRHERL
210 220 230 240 250
LQAAQRRQQK NSVLTNCNST PDSGPNSPPS AAALAVGVVG SRGSPTSAPI
260 270 280 290 300
QEENEEGSQY QPGQRSSIND LPLFSSPSLP NISLGRPHLP NSAQAHAQVN
310 320 330 340 350
AQVAAQAQAQ AQAQAQAHAM FAALAAAQGG CGQPGYYNPL GMAFVGRQPA
360 370 380 390 400
PLAMIPATGI APQQPSPVVR SASATSTSSS QASLVGDVAP PQAHAASTIL
410 420 430 440 450
PSSSSYMQQL GSVAGSGVNL HAAAVAAAAA AAAAAGSLPP TNSHGHGHGS
460 470 480 490 500
HAHPHPHAHG HGHGHGHGIY AGHQHNVPIT DAQVAQVHLH KQGHRPLGRT
510 520 530 540 550
QSAPLPLGHP MLTGAVQLNV VQTHYENSEA ERQAYEHQVV NQKVRQTVLT
560 570 580 590 600
RSGAAAAAAA AAGVSVVREA QLKEEDDDSA AEVMDLTDKK KPPKTVLTST
610 620 630 640 650
IATSTSQNLP EALAAAAAAA AYRAPHNASS NSASATKSGI KLRDQEYLQQ
660 670 680 690 700
QREQLLLLQQ EEELAKSLMR PLSRTLSSPL VPLGPHGLSQ IPDTGQQPAP
710 720 730 740 750
IATSSSADHI PPVNLSLPHR QHRQLMSTLY ASQLRNHQPS ASGSPPHKVT
760 770 780 790 800
TGLAYDPLML KHSCICGDNA QHPEHSGRLQ SVWARLNETD LVKRCDRLRA
810 820 830 840 850
RKATQEELQT VHTEAHAMLF GSNQCQLSRP KLENTLSASF VRLSCGGLGV
860 870 880 890 900
DLDTTWNEHH TATAARMAAG CVIDLALKTA KGDLRNGFAV VRPPGHHAEA
910 920 930 940 950
NLAMGFCFFN SIAIAAKLLR QRMPEVRRIL IVDWDVHHGN GTQQAFYQSP
960 970 980 990 1000
DILYLSIHRH DDGNFFPGTG GPTECGSGAG LGFNVNISWS GALNPPLGDA
1010 1020 1030 1040 1050
EYIAAFRTVV MPIARSFNPD IVLVSSGFDA ATGHPAPLGG YHVSPACFGF
1060 1070 1080 1090 1100
MTRELLQLAN GKVVLALEGG YDLAAICDSA QECVRALLGD PAAPIAKAEL
1110 1120 1130 1140 1150
ERPPCQNAIN TLQKTIAIQQ THWPCVRMLE HTVGLSALET LKVEHDESET
1160 1170 1180
INAMAGLSMQ SMHRTLSRDD SEEPMDQDET K
Length:1,181
Mass (Da):126,044
Last modified:March 1, 2003 - v1
Checksum:iAD451B406E8719B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAN09318.1.
AE014298 Genomic DNA. Translation: AGB95350.1.
RefSeqiNP_001259508.1. NM_001272579.2.
NP_727682.1. NM_167356.3.
UniGeneiDm.6484.

Genome annotation databases

EnsemblMetazoaiFBtr0073798; FBpp0073629; FBgn0041210.
FBtr0333332; FBpp0305524; FBgn0041210.
GeneIDi32278.
KEGGidme:Dmel_CG1770.
UCSCiCG1770-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAN09318.1 .
AE014298 Genomic DNA. Translation: AGB95350.1 .
RefSeqi NP_001259508.1. NM_001272579.2.
NP_727682.1. NM_167356.3.
UniGenei Dm.6484.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0073798 ; FBpp0073629 ; FBgn0041210 .
FBtr0333332 ; FBpp0305524 ; FBgn0041210 .
GeneIDi 32278.
KEGGi dme:Dmel_CG1770.
UCSCi CG1770-RB. d. melanogaster.

Organism-specific databases

CTDi 9759.
FlyBasei FBgn0041210. HDAC4.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
KOi K11406.

Miscellaneous databases

GenomeRNAii 32278.
NextBioi 777716.

Gene expression databases

Bgeei Q8IR69.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ8IR69_DROME
AccessioniPrimary (citable) accession number: Q8IR69
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3