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Q8IR69

- Q8IR69_DROME

UniProt

Q8IR69 - Q8IR69_DROME

Protein
Submitted name:

HDAC4, isoform B

Gene

HDAC4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: FlyBase

    GO - Biological processi

    1. histone deacetylation Source: GOC
    2. regulation of transcription, DNA-templated Source: FlyBase

    Keywords - Molecular functioni

    HydrolaseSAAS annotationImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HDAC4, isoform BImported (EC:3.5.1.-Imported)
    Submitted name:
    HDAC4, isoform HImported (EC:3.5.1.-Imported)
    Gene namesi
    Name:HDAC4Imported
    ORF Names:CG1770Imported, Dmel_CG1770Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0041210. HDAC4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. histone deacetylase complex Source: InterPro
    3. nucleus Source: FlyBase

    Expressioni

    Gene expression databases

    BgeeiQ8IR69.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000062809.
    InParanoidiQ8IR69.
    KOiK11406.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q8IR69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELEHKLQLE HKYQFAVNSH GAFQELRNES MVTAAAAAVA QEQHRQQLHQ     50
    QQQQHQQQQQ QQQHQQQQQQ QQARGRDGMK LKQNCSANAS PEVKQILNCF 100
    ILSRKSQAAA SNGTTTTSPY RNRGVVKSSS GESLPAGTVT SAHPYKIPQP 150
    PPSLLKYESD FPLRKTASEP NLLKIRLKQS VIERKARIGG PAGARRHERL 200
    LQAAQRRQQK NSVLTNCNST PDSGPNSPPS AAALAVGVVG SRGSPTSAPI 250
    QEENEEGSQY QPGQRSSIND LPLFSSPSLP NISLGRPHLP NSAQAHAQVN 300
    AQVAAQAQAQ AQAQAQAHAM FAALAAAQGG CGQPGYYNPL GMAFVGRQPA 350
    PLAMIPATGI APQQPSPVVR SASATSTSSS QASLVGDVAP PQAHAASTIL 400
    PSSSSYMQQL GSVAGSGVNL HAAAVAAAAA AAAAAGSLPP TNSHGHGHGS 450
    HAHPHPHAHG HGHGHGHGIY AGHQHNVPIT DAQVAQVHLH KQGHRPLGRT 500
    QSAPLPLGHP MLTGAVQLNV VQTHYENSEA ERQAYEHQVV NQKVRQTVLT 550
    RSGAAAAAAA AAGVSVVREA QLKEEDDDSA AEVMDLTDKK KPPKTVLTST 600
    IATSTSQNLP EALAAAAAAA AYRAPHNASS NSASATKSGI KLRDQEYLQQ 650
    QREQLLLLQQ EEELAKSLMR PLSRTLSSPL VPLGPHGLSQ IPDTGQQPAP 700
    IATSSSADHI PPVNLSLPHR QHRQLMSTLY ASQLRNHQPS ASGSPPHKVT 750
    TGLAYDPLML KHSCICGDNA QHPEHSGRLQ SVWARLNETD LVKRCDRLRA 800
    RKATQEELQT VHTEAHAMLF GSNQCQLSRP KLENTLSASF VRLSCGGLGV 850
    DLDTTWNEHH TATAARMAAG CVIDLALKTA KGDLRNGFAV VRPPGHHAEA 900
    NLAMGFCFFN SIAIAAKLLR QRMPEVRRIL IVDWDVHHGN GTQQAFYQSP 950
    DILYLSIHRH DDGNFFPGTG GPTECGSGAG LGFNVNISWS GALNPPLGDA 1000
    EYIAAFRTVV MPIARSFNPD IVLVSSGFDA ATGHPAPLGG YHVSPACFGF 1050
    MTRELLQLAN GKVVLALEGG YDLAAICDSA QECVRALLGD PAAPIAKAEL 1100
    ERPPCQNAIN TLQKTIAIQQ THWPCVRMLE HTVGLSALET LKVEHDESET 1150
    INAMAGLSMQ SMHRTLSRDD SEEPMDQDET K 1181
    Length:1,181
    Mass (Da):126,044
    Last modified:March 1, 2003 - v1
    Checksum:iAD451B406E8719B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAN09318.1.
    AE014298 Genomic DNA. Translation: AGB95350.1.
    RefSeqiNP_001259508.1. NM_001272579.1.
    NP_727682.1. NM_167356.3.
    UniGeneiDm.6484.

    Genome annotation databases

    EnsemblMetazoaiFBtr0073798; FBpp0073629; FBgn0041210.
    FBtr0333332; FBpp0305524; FBgn0041210.
    GeneIDi32278.
    KEGGidme:Dmel_CG1770.
    UCSCiCG1770-RB. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAN09318.1 .
    AE014298 Genomic DNA. Translation: AGB95350.1 .
    RefSeqi NP_001259508.1. NM_001272579.1.
    NP_727682.1. NM_167356.3.
    UniGenei Dm.6484.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0073798 ; FBpp0073629 ; FBgn0041210 .
    FBtr0333332 ; FBpp0305524 ; FBgn0041210 .
    GeneIDi 32278.
    KEGGi dme:Dmel_CG1770.
    UCSCi CG1770-RB. d. melanogaster.

    Organism-specific databases

    CTDi 9759.
    FlyBasei FBgn0041210. HDAC4.

    Phylogenomic databases

    GeneTreei ENSGT00530000062809.
    InParanoidi Q8IR69.
    KOi K11406.

    Miscellaneous databases

    GenomeRNAii 32278.
    NextBioi 777716.

    Gene expression databases

    Bgeei Q8IR69.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ8IR69_DROME
    AccessioniPrimary (citable) accession number: Q8IR69
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3