Unreviewed, UniProtKB/TrEMBL Q8IQX8 (Q8IQX8_DROME)

Names and origin

Protein names

Submitted name:
    Histidyl-tRNA synthetase, isoform B EMBL AAN09471.1
    EC=6.1.1.21

Gene names

Name:	Aats-his EMBL AAN09471.1
ORF Names:	Dmel_CG6335 EMBL AAN09471.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	563 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. RuleBase RU003746V0

Ontologies

Keywords
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro histidine-tRNA ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IQX8-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5E4709C97955DCF2	FASTA	563	62,275
	10 20 30 40 50 60 MSDTREQILE QIKVQGDLVR QLKAAKESKE KHLSNPHHVH VPSLKSFPAS PLQIDEEVAR 70 80 90 100 110 120 LLALKATLGG DAAPTNQKFT LKTPKGTRDY GPQQMTLRQG VLDKIVQVFK RHGGEAIDTP 130 140 150 160 170 180 VFELKVSSPG SHWSGMILFK TMRIEVLTGK YGEDSKLIYD LKDQGGEILS MRYDLTVPLA 190 200 210 220 230 240 RYLAMNKISS IKRYHIAKVY RRDNPAMTKG RYREFYQCDF DIAGTYDPML PDAECVKIVS 250 260 270 280 290 300 EILDTLDIGD YVIKLNHRQL LDGMFQACGV PADSFRTICS AVDKLDKSPW ADVRKEMVDE 310 320 330 340 350 360 KGLDEAAADR IGEYVRLSGG AELVEQLLAN EKLKAVPNAV KGLEGMKQLL KYCSIFGLDK 370 380 390 400 410 420 RVSFDLSLAR GLDYYTGVIY EGVLKGESAT VASPAKTSQQ NGEQANEPAT VGSVAGGGRY 430 440 450 460 470 480 DNLVGMFDPR GKAVPCVGVS IGVERIFSVL EARAAASGLK LRTSDVEVYV ASAHKGLHEQ 490 500 510 520 530 540 RLKVLNLLWD AGVKAEHSYK LNPKLLVQLQ HCEEHQIPLV VVLGDAELAQ GLVKLREVTT 550 560 REETNVKLED LAAEIRRRQQ ASA

References

[1]

"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

[2]

"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014298 Genomic DNA. Translation: AAN09471.1.
RefSeq	NP_573305.1.
UniGene	Dm.11373
3D structure databases
HSSP	HSSP built from PDB template 1H4V based on UniProtKB P56194.
ModBase	Search...
Proteomic databases
PRIDE	Q8IQX8.
Genome annotation databases
Ensembl	FBgn0027087. Drosophila melanogaster. [Contig view]
GeneID	32841.
KEGG	dme:Dmel_CG6335.
NMPDR	fig|7227.3.peg.18509.
Organism-specific databases
FlyBase	FBgn0027087. Aats-his.
Phylogenomic databases
HOGENOM	Q8IQX8.
OMA	Q8IQX8. LDKSPWE.
Gene expression databases
ArrayExpress	Q8IQX8.
Family and domain databases
InterPro	IPR002314. aa-tRNA-synt_IIb_cons-reg. IPR006195. aa-tRNA-synth_II_cons-reg. IPR004154. Anticodon_bd. IPR004516. His-tRNA_synth_IIA. IPR000738. WHEP-TRS. [Graphical view]
Gene3D	G3DSA:3.40.50.800. Anticodon_bd. 1 hit.
PANTHER	PTHR11476. His-tRNA_synth. 1 hit.
Pfam	PF03129. HGTP_anticodon. 1 hit. PF00587. tRNA-synt_2b. 1 hit. PF00458. WHEP-TRS. 1 hit. [Graphical view]
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. PS51185. WHEP_TRS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	780657.

Entry information

Entry name

Q8IQX8_DROME

Accession

Primary (citable) accession number: Q8IQX8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)