Unreviewed, UniProtKB/TrEMBL Q8IQB8 (Q8IQB8_DROME)

Names and origin

Protein names

Submitted name:
    Tequila, isoform D EMBL AAN11984.1
    EC=3.4.21.-
    EC=3.4.21.36
    EC=3.4.21.4
    EC=3.4.21.71

Gene names

Name:	Tequila EMBL AAN11984.1
ORF Names:	Dmel_CG4821 EMBL AAN11984.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
PTM	Disulfide bond Spearmint SPM001190
Gene Ontology (GO)
Biological process	chitin metabolic process Inferred from electronic annotation. Source: InterPro long-term memory Inferred from mutant phenotype. Source: FlyBase proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: InterPro membrane Inferred from electronic annotation. Source: InterPro
Molecular function	chitin binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct scavenger receptor activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Pi3K21B	O18683	1	EBI-129121,EBI-136889
SCAP	Q9V9J7	1	EBI-129121,EBI-146755

Sequences

	Sequence		Length	Mass (Da)
	Q8IQB8-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: E4CC56D104CC3735	FASTA	1,450	160,131
	10 20 30 40 50 60 MMAKWLLGLW LAILLVDRPG AKAYRSGSGY HSEQSEPVGL SATGNAHSSY GGDQQQPIYH 70 80 90 100 110 120 RDSACPPHFT GLVAYPHDCH RYVNCFDGSP TIQTCSPGTL FNDRTQVCDH PSNVVCPSAE 130 140 150 160 170 180 SASTRLGRLR QLDSEPKCQP GVNGLQPHPS DCSKFLNCAN GQAFIMDCAP GTAFSPASLV 190 200 210 220 230 240 CVHKDLAKCG SGTGAVRDDT SGTDNRQSKS YETSGRDQFG NRYTTRTTTT TRVIGDRWTD 250 260 270 280 290 300 MNMQRPSGVG VEQNPHHHHH GYNPGWSGQE TSYVQRGPTQ STLYVEGSLQ PNRNYPTNKT 310 320 330 340 350 360 PLAPMAPTNT GGVYYGQPVE DKQNVPSRQN YSRRIDYGSP GNGWKPMPPL DPLGGQQPLN 370 380 390 400 410 420 LDYSPHSPGA KEPQSQDSLP GQKPINLDYD EEPIPQYLHN GLPPYPGSPP RFYPDQLPSG 430 440 450 460 470 480 SKPIGRQQPV ESSPDASGYP DQQKPLDPDN GLHGSKVPPR HSPNPGYPLY NESNLYGGLL 490 500 510 520 530 540 PPKPDSPVNT TPTPTPNPSS SQAPTPQLAN RLHTFPIYPP VDNKTSLRNP IQPHYSPSYA 550 560 570 580 590 600 GIAHSRDAPW AKVPVTSTTP AQDPDPFNPE LDEPFYDDVD FLTTTVRNVL VPPPFDHKFY 610 620 630 640 650 660 SPQSTNPSIN RNQSASGPNS QAAIKEALKL MLRPYFNHSG NAQEQLAQQA ESAIVSVISK 670 680 690 700 710 720 PSTTTTTTPR PTSKTPKTDP DFDAELIKAG EQESLDSVDD DYVFPDARET SRTEQTLDPS 730 740 750 760 770 780 TTYASTNFQR STRRAELDPD TLTATTMKTN WHAPGHSRDY HRRHPNLPDP FTEHHPNSSP 790 800 810 820 830 840 HQHHHHHRHP HEHSADFHIR HPELPNPFPL KNETPQHQDL NDDWDLLPNS NAEEVTPKLA 850 860 870 880 890 900 TRSSFNTQCD FDCGNGQCLK KEEICDGKKN CPNGKDEANC PPSDYEVRLS GGESPNMGRI 910 920 930 940 950 960 EVKANGQWGY VCDDKFGLKD ADVVCRELGF QMGAQEVRGS SFYAPPNQDF NYLMDEVECH 970 980 990 1000 1010 1020 GNETKLGQCA FKGWGVHNCG VDEVAGVTCK VPVMKCPNNY WLCHTSKECI PPAFVCDNTP 1030 1040 1050 1060 1070 1080 DCADKSDECA AVCQAPVQYR LEGGRNSNEG RLEVKHHGVW GSVCDDDFNL KSAQVACNSM 1090 1100 1110 1120 1130 1140 GFFGPAKIEK NIFGNSNGPI WLDQVMCFGN ETSIDQCNHW NWGEHNCNHT EDVALHCSAG 1150 1160 1170 1180 1190 1200 PPPRSQRYSQ TQIKGGRSLG RETTPKTYSQ IGLWERSSKA VHTPRRCGIF KDDLTDEYAH 1210 1220 1230 1240 1250 1260 REERVVRGNV AQRGRHPWQA TIRTRGRGGI SSHWCGAVVI SKRHLLTAAH CLYGSPKGAY 1270 1280 1290 1300 1310 1320 FVRVGDHYAN IAESSEVDSF IENWYLHENF RKGTHMNNDI ALVVLKTPLK FSDYVQPICL 1330 1340 1350 1360 1370 1380 PDKNAELVED RKCTISGWGS IKSGVSTPAQ VLGSAELPIL ADHVCKQSNV YGSAMSEGMF 1390 1400 1410 1420 1430 1440 CAGSMDESVD ACEGDSGGPL VCSDDDGETL YGLISWGQHC GFKNRPGVYV RVNHYIDWIY 1450 EKINESLLRF

References

[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014296 Genomic DNA. Translation: AAN11984.1.
RefSeq	NP_729451.1.
UniGene	Dm.7691
3D structure databases
HSSP	HSSP built from PDB template 1EZX based on UniProtKB P00760.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IQB8. 27 interactions.
Protein family/group databases
CAZy	CBM14. Carbohydrate-Binding Module Family 14.
MEROPS	S01.461.
Proteomic databases
PRIDE	Q8IQB8.
Genome annotation databases
Ensembl	FBgn0023479. Drosophila melanogaster. [Contig view]
GeneID	39048.
NMPDR	fig|7227.3.peg.8993.
Organism-specific databases
FlyBase	FBgn0023479. Tequila.
Gene expression databases
ArrayExpress	Q8IQB8.
Family and domain databases
InterPro	IPR020003. ATPase_F1/V1/A1_a/bsu_AS. IPR002557. Chitin-bd_peritrophin-A. IPR002172. LDL_rcpt_classA_cys-rich. IPR018114. Peptidase_S1/S6_AS. IPR001254. Peptidase_S1_S6. IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. [Graphical view]
Pfam	PF01607. CBM_14. 2 hits. PF00057. Ldl_recept_a. 1 hit. PF00530. SRCR. 2 hits. PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00261. LDLRECEPTOR.
SMART	SM00494. ChtBD2. 2 hits. SM00192. LDLa. 2 hits. SM00202. SR. 2 hits. SM00020. Tryp_SPc. 1 hit. [Graphical view]
PROSITE	PS00152. ATPASE_ALPHA_BETA. 1 hit. Uncertain. PS50940. CHIT_BIND_II. 2 hits. PS01209. LDLRA_1. 1 hit. PS50068. LDLRA_2. 2 hits. PS00420. SRCR_1. 2 hits. PS50287. SRCR_2. 2 hits. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	811642.

Entry information

Entry name

Q8IQB8_DROME

Accession

Primary (citable) accession number: Q8IQB8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)