Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8IQ27 (Q8IQ27_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435
EC=3.4.19.12 RuleBase RU004435
Gene names
Name:CG14619-RC EMBL ACY46087.1
ORF Names:CG14619 EMBL AAO39652.1 FlyBase FBgn0031187, Dmel_CG14619 EMBL AAN09566.1
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length938 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435

Sequence similarities

Belongs to the peptidase C19 family. RuleBase RU004434

Sequences

Sequence LengthMass (Da)Tools
Q8IQ27 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6CD54A8DF5E2C4D1

FASTA938101,704
        10         20         30         40         50         60 
MMLDIKKTRG FHKIPQASKL QSTTKTSSVV ATSASSQNEV PSPGGSAGSK VGATNPVRAA 

        70         80         90        100        110        120 
NQRFFLVSSY KDPTFLKAEC DLAHAHVTTS KVKTTLQPHR RSRAGEDSRN NNYNTSRAPT 

       130        140        150        160        170        180 
LINMRRPSLF NGNQQPTTTN STTINNTTSR NTTSNTSNGV LKYSVRSTTA TATSTSTRNY 

       190        200        210        220        230        240 
GKLKPLNNNQ TTAGVAMMNG HTNNNNNNTR NSSNINNGGN NNMQRQQQQH DDISFIDSDD 

       250        260        270        280        290        300 
PPATGGPEAG ISTTKTSICY FKPITPPLQL RHEQNQVQQQ EEQPQPSSSK SASHRYPRPK 

       310        320        330        340        350        360 
STIIASAHSN FAASFEKFSG GLYRQTNGET NIESKTSSNA RRYGIDSLSI KASIEKFNNL 

       370        380        390        400        410        420 
SGQKRQNPGS GSGIGPGSAT ASGLGGGRLS VASRSNHGSQ AGGSSSNLQQ RYSSDLDNIR 

       430        440        450        460        470        480 
VAAGYSSSLT RAAYRTTATM NSVSTPVAVT SELGGPISGD GGETATAMGQ PTSKVTVRGA 

       490        500        510        520        530        540 
HSNRQPIECD SVVLTNKASK DATTAATPTV ATATATHTPA TSSVSTVTVT AAAPNSASDS 

       550        560        570        580        590        600 
TLARSGTGSS STARSVLPPM TPTSSRYWDR DSGTSRSSIG TSSALNSSSL KHNSDDGYKT 

       610        620        630        640        650        660 
ASSSRDEKSE GLCGLRNIGN TCFMNSVIQC LSHTQELTRF LRSHHGSRSL STKDQQILHE 

       670        680        690        700        710        720 
FAKLIQEMWT ANVHTVTPME LKRAFSTKHR MYSDYNQQDA QEFLRFFLDS LHSALNSGVK 

       730        740        750        760        770        780 
GETLNIDDNL SDNKKADLTW EWYTRHENSL VRDLFVGQLK STLKCTTCGN TSVTFDPFWD 

       790        800        810        820        830        840 
LSVPLPSSSR CKLEACLDLF IREEVLDGDE MPTCAKCKTR RKCTKSFTIQ RFPKYLVIHL 

       850        860        870        880        890        900 
KRFSETRWSK LSNIVEFPTS DSELNMGSYG ANSNSNVHYS LYAISNHMGS TAGGHYVALC 

       910        920        930 
KHPVSRKWHE FNDNIVSDAL SENHLVSSSA YILFYERT

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley.
[3]Carlson J., Booth B., Frise E., Sandler J., Wan K., Yu C., Celniker S.
Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014298 Genomic DNA. Translation: AAN09566.1.
BT003648 mRNA. Translation: AAO39652.1.
BT100212 mRNA. Translation: ACY46087.1.
RefSeqNP_728455.1. NM_167777.1.
UniGeneDm.1945.

3D structure databases

HSSPHSSP built from PDB template 1NBF based on UniProtKB Q93009.
ProteinModelPortalQ8IQ27.
SMRQ8IQ27. Positions 609-938.
ModBaseSearch...

Protein family/group databases

MEROPSC19.A24.

Proteomic databases

PRIDEQ8IQ27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0077349; FBpp0077041; FBgn0031187.
GeneID33132.
KEGGdme:Dmel_CG14619.
NMPDRfig|7227.3.peg.18944.
UCSCCG14619-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0031187. CG14619.

Phylogenomic databases

GeneTreeEMGT00050000001408.
InParanoidQ8IQ27.
PhylomeDBQ8IQ27.

Gene expression databases

ArrayExpressQ8IQ27.
BgeeQ8IQ27.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
[Graphical view]
KOK11833.
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio782065.

Entry information

Entry nameQ8IQ27_DROME
AccessionPrimary (citable) accession number: Q8IQ27
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info