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Protein

Aspartate aminotransferase

Gene

Got2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.UniRule annotation

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • aspartate catabolic process Source: GO_Central
  • aspartate metabolic process Source: FlyBase
  • glutamate biosynthetic process Source: FlyBase
  • neurotransmitter receptor metabolic process Source: FlyBase
  • synapse assembly Source: FlyBase

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferaseUniRule annotation (EC:2.6.1.1UniRule annotation)
Gene namesi
Name:Got2Imported
Synonyms:152801_atImported, Dmel\CG4233Imported, GotImported, Got 2Imported, Got-2Imported, got2Imported, Got2-RBImported
ORF Names:CG4233Imported, Dmel_CG4233Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001125 Got2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ8IPY3

Expressioni

Gene expression databases

BgeeiFBgn0001125
ExpressionAtlasiQ8IPY3 baseline and differential

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ8IPY3, 1 interactor
STRINGi7227.FBpp0077537

Structurei

3D structure databases

SMRiQ8IPY3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 426Aminotran_1_2InterPro annotationAdd BLAST368

Phylogenomic databases

eggNOGiKOG1411 Eukaryota
COG1448 LUCA
GeneTreeiENSGT00390000014081
OrthoDBiEOG091G06G3

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR000796 Asp_trans
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11879 PTHR11879, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
PRINTSiPR00799 TRANSAMINASE
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IPY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIIMTLK DIVHVWSNDP GERMCRANRV STWFSEVQMG PPDAILGVTE
60 70 80 90 100
AFKKDTNPKK INLGAGAYRD DNTQPFVLPS VREAEKRVVS RSLDKEYATI
110 120 130 140 150
IGIPEFYNKA IELALGKGSK RLAAKHNVTA QSISGTGALR IGAAFLAKFW
160 170 180 190 200
QGNREIYIPS PSWGNHVAIF EHAGLPVNRY RYYDKDTCAL DFGGLIEDLK
210 220 230 240 250
KIPEKSIVLL HACAHNPTGV DPTLEQWREI SALVKKRNLY PFIDMAYQGF
260 270 280 290 300
ATGDIDRDAQ AVRTFEADGH DFCLAQSFAK NMGLYGERAG AFTVLCSDEE
310 320 330 340 350
EAARVMSQVK ILIRGLYSNP PVHGARIAAE ILNNEDLRAQ WLKDVKLMAD
360 370 380 390 400
RIIDVRTKLK DNLIKLGSSQ NWDHIVNQIG MFCFTGLKPE QVQKLIKDHS
410 420 430
VYLTNDGRVS MAGVTSKNVE YLAESIHKVT K
Length:431
Mass (Da):48,172
Last modified:March 1, 2003 - v1
Checksum:i5896228BEAC1C555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAN10437.1
BT125856 mRNA Translation: ADU79244.1
RefSeqiNP_722745.1, NM_164446.1
UniGeneiDm.7215

Genome annotation databases

EnsemblMetazoaiFBtr0077868; FBpp0077537; FBgn0001125
GeneIDi33373

Similar proteinsi

Entry informationi

Entry nameiQ8IPY3_DROME
AccessioniPrimary (citable) accession number: Q8IPY3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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