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Protein

Aspartate aminotransferase

Gene

Got2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.UniRule annotation

Catalytic activityi

L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • aspartate catabolic process Source: GO_Central
  • aspartate metabolic process Source: FlyBase
  • glutamate biosynthetic process Source: FlyBase
  • neurotransmitter receptor metabolic process Source: FlyBase
  • synapse assembly Source: FlyBase

Keywordsi

Molecular functionAminotransferaseUniRule annotationImported, Transferase

Enzyme and pathway databases

ReactomeiR-DME-389661. Glyoxylate metabolism and glycine degradation.
R-DME-70263. Gluconeogenesis.
R-DME-70614. Amino acid synthesis and interconversion (transamination).

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate aminotransferaseUniRule annotation (EC:2.6.1.1UniRule annotation)
Gene namesi
Name:Got2Imported
Synonyms:152801_atImported, Dmel\CG4233Imported, GotImported, Got 2Imported, Got-2Imported, got2Imported, Got2-RBImported
ORF Names:CG4233Imported, Dmel_CG4233Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001125. Got2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: FlyBase
  • mitochondrion Source: FlyBase

Expressioni

Gene expression databases

BgeeiFBgn0001125.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

IntActiQ8IPY3. 1 interactor.
STRINGi7227.FBpp0077537.

Structurei

3D structure databases

SMRiQ8IPY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 426Aminotran_1_2InterPro annotationAdd BLAST368

Phylogenomic databases

eggNOGiKOG1411. Eukaryota.
COG1448. LUCA.
GeneTreeiENSGT00390000014081.
OMAiRVGACTI.
OrthoDBiEOG091G06G3.

Family and domain databases

Gene3Di3.90.1150.10. 2 hits.
InterProiView protein in InterPro
IPR004839. Aminotransferase_I/II.
IPR000796. Asp_trans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015422. PyrdxlP-dep_Trfase_sub2.
PANTHERiPTHR11879. PTHR11879. 1 hit.
PfamiView protein in Pfam
PF00155. Aminotran_1_2. 1 hit.
PRINTSiPR00799. TRANSAMINASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00105. AA_TRANSFER_CLASS_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IPY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIIMTLK DIVHVWSNDP GERMCRANRV STWFSEVQMG PPDAILGVTE
60 70 80 90 100
AFKKDTNPKK INLGAGAYRD DNTQPFVLPS VREAEKRVVS RSLDKEYATI
110 120 130 140 150
IGIPEFYNKA IELALGKGSK RLAAKHNVTA QSISGTGALR IGAAFLAKFW
160 170 180 190 200
QGNREIYIPS PSWGNHVAIF EHAGLPVNRY RYYDKDTCAL DFGGLIEDLK
210 220 230 240 250
KIPEKSIVLL HACAHNPTGV DPTLEQWREI SALVKKRNLY PFIDMAYQGF
260 270 280 290 300
ATGDIDRDAQ AVRTFEADGH DFCLAQSFAK NMGLYGERAG AFTVLCSDEE
310 320 330 340 350
EAARVMSQVK ILIRGLYSNP PVHGARIAAE ILNNEDLRAQ WLKDVKLMAD
360 370 380 390 400
RIIDVRTKLK DNLIKLGSSQ NWDHIVNQIG MFCFTGLKPE QVQKLIKDHS
410 420 430
VYLTNDGRVS MAGVTSKNVE YLAESIHKVT K
Length:431
Mass (Da):48,172
Last modified:March 1, 2003 - v1
Checksum:i5896228BEAC1C555
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAN10437.1.
BT125856 mRNA. Translation: ADU79244.1.
RefSeqiNP_722745.1. NM_164446.1.
UniGeneiDm.7215.

Genome annotation databases

EnsemblMetazoaiFBtr0077868; FBpp0077537; FBgn0001125.
GeneIDi33373.

Similar proteinsi

Entry informationi

Entry nameiQ8IPY3_DROME
AccessioniPrimary (citable) accession number: Q8IPY3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported