Q8INJ8 (Q8INJ8_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
C-terminal Src kinase, isoform G EMBL AAN13523.2
EC=2.7.10.- EMBL AAN13523.2
EC=2.7.10.2 EMBL AAN13523.2

Gene names

Name:	Csk FlyBase FBgn0259217 FlyBase FBgn0262081
ORF Names:	Dmel_CG42317 EMBL AAN13523.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1052 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS020635
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS020635

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS020635 RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS020635
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8INJ8 [UniParc]. Last modified March 3, 2009. Version 2. Checksum: AF8526F2D763C586	FASTA	1,052	113,747
	10 20 30 40 50 60 MVTTIKITCD GVFIQSNSYL MPTPSPSGAD ATVSSSLERV LKPASASASP SNSNNESDNS 70 80 90 100 110 120 QTSSGSQTAS SASKRSNRSV GRSHRGSIAQ DTRRRYYFGS KDIYWCKQSR EAAAAATLSG 130 140 150 160 170 180 SGLTRSASSV THKEASTHAT HTGGQVISRA RRKPILLCSS LSAAYAPPRR REFYFCDKYA 190 200 210 220 230 240 PGPARSTPTT TTTSATSAKH ESSPPIDARL LNFLRCAHRK FQASKAKTEL QQTKDRFLGN 250 260 270 280 290 300 SRERTSKNGQ QTSRSLPPIA SSEEWFDEEA QARKTSHEKS QKPKPKPEEN HKEKEAISRK 310 320 330 340 350 360 ASGEGDLITV EIKQGLLRKQ TATTTTGQAM NSHATATQNG QTTVVGHHRG FSQPSVTVAA 370 380 390 400 410 420 AAATGSTAGD PWFLQTTGHQ MPPTAPLRHN KRPAPQPNAV LGAGSSGTAP GSAVGAVLLH 430 440 450 460 470 480 QQQLSQSQPH IVPPSIPPHH HHHRENNVHP IQAGAAAALH LSSHALNSHN LISSASNHSP 490 500 510 520 530 540 KSPSQTQQQQ QTTNQQQQQQ QQQASHSILS TFAPAPTVAA VQPAGSQSVA GTAAAVAAVA 550 560 570 580 590 600 QQQQQQHLQL LANCPPGGAG LMSSSLNAAQ MGMHGAERAL PPKSLALSGS QHGSNMLLHT 610 620 630 640 650 660 APQPPQASQP AAVVGVSGSG SAGMSTSLHS FDINGVTAGS GVNASSAWSS GSTTAMNHAS 670 680 690 700 710 720 LSPTALAPQQ GRSRCEVKLN AMPWFHGSIT RDEAEHLLQP REDGLFLVRE STNFPGDYTL 730 740 750 760 770 780 CVCFQSKVEH YRVKYLENKL TIDDEEYFEN LGQLVAHYEA DADGLCTQLI KCLPKLGKQE 790 800 810 820 830 840 FCINSKDFVD KGWVIPEAEL QLRESIGKGE FGDVMLGILR NEKVAVKMLK DEGAVQKFLA 850 860 870 880 890 900 EASVMTTLEH DNLVKFIGLV FTSKHLYLVT EYMSKGSLVD YLRSRGRQHI TKKDQIIFAY 910 920 930 940 950 960 DTASGMEYLE AKKVVHRDLA ARNVLISEDC VAKVSDFGLA REECYNLDVG KLPIKWTAPE 970 980 990 1000 1010 1020 ALKNGRFSNK SDMWSFGILL WEIYSFGRVP YPRIPLADVV KHVEVGYKME APEGCPPEIY 1030 1040 1050 EMMRQAWDLN PAKRPTFAEL KVKLQLLNNA TA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014297 Genomic DNA. Translation: AAN13523.2.
RefSeq	NP_731611.2. NM_169418.2.
UniGene	Dm.37763.
3D structure databases
ProteinModelPortal	Q8INJ8.
SMR	Q8INJ8. Positions 627-1050.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-785068.
STRING	Q8INJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0299729; FBpp0289007; FBgn0262081.
GeneID	41398.
KEGG	dme:Dmel_CG42317.
Organism-specific databases
CTD	1445.
FlyBase	FBgn0262081. Csk.
Phylogenomic databases
GeneTree	EMGT00050000002730.
InParanoid	Q8INJ8.
PhylomeDB	Q8INJ8.
Gene expression databases
ArrayExpress	Q8INJ8.
Bgee	Q8INJ8.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Gene3D	G3DSA:3.30.505.10. SH2. 1 hit.
KO	K05728.
Pfam	PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. [Graphical view]
PRINTS	PR00401. SH2DOMAIN. PR00109. TYRKINASE.
SMART	SM00252. SH2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	845319.

Entry information

Entry name

Q8INJ8_DROME

Accession

Primary (citable) accession number: Q8INJ8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)