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Q8IN81 (FRU_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 18, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sex determination protein fruitless
Gene names
Name:fru
Synonyms:BTB-VI
ORF Names:CG14307
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length955 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associated fat body. Ref.1 Ref.2 Ref.3 Ref.4 Ref.8 Ref.9 Ref.10

Subcellular location

Nucleus Potential Ref.8.

Tissue specificity

Expressed in parts of the adult male brain associated with the courtship song and steps of the male courtship. Also expressed in the larval and pupal male mushroom body and optic lobe. Expressed in pupal female optic lobe. Ref.1 Ref.2 Ref.3 Ref.4

Disruption phenotype

Mutant males exhibit bisexual behavior; they court females but are behaviorally sterile so fail to mate and they exhibit vigorous courtship with other fru mutant males. Ref.1

Sequence similarities

Contains 1 BTB (POZ) domain.

Contains 1 C2H2-type zinc finger.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaggressive behavior

Inferred from mutant phenotype PubMed 18042702. Source: FlyBase

axon midline choice point recognition

Inferred from mutant phenotype PubMed 20040498. Source: FlyBase

central nervous system development

Inferred from mutant phenotype PubMed 12524343. Source: FlyBase

copulation

Non-traceable author statement PubMed 12486700. Source: FlyBase

dendrite morphogenesis

Inferred from mutant phenotype PubMed 21471381. Source: FlyBase

male courtship behavior, orientation prior to leg tapping and wing vibration

Non-traceable author statement PubMed 12000098. Source: FlyBase

male courtship behavior, veined wing generated song production

Inferred from mutant phenotype Ref.1. Source: UniProtKB

male sex differentiation

Traceable author statement PubMed 12486700. Source: FlyBase

mating behavior, sex discrimination

Inferred from mutant phenotype PubMed 20967276. Source: FlyBase

muscle organ development

Inferred from mutant phenotype Ref.3Ref.1. Source: UniProtKB

sex determination

Inferred from mutant phenotype Ref.3Ref.1. Source: UniProtKB

transcription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Non-traceable author statement. Source: UniProtKB

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.8. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 13 isoforms produced by alternative splicing. [Align] [Select]

Note: Sex specific splicing is controlled by tra and tra-2. Sex-specific repression of the translation of fru mRNA might be mediated by the binding of Tra to the fru mRNA in females.
Isoform Male-A Ref.4 (identifier: Q8IN81-1)

Also known as: E;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Female-A Ref.4 (identifier: Q8IN81-4)

Also known as: C; L; M;

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
Isoform Female-B Ref.4 (identifier: Q8IN81-7)

Also known as: F;

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflict6501T → A in AAG28589. Ref.3
Isoform Female-E Ref.4 (identifier: Q8IN81-10)

Also known as: H;

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.
Isoform Female-I Ref.1 (identifier: Q8IN81-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     324-336: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.
Isoform Male-B Ref.4 (identifier: Q8IN81-6)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.
Isoform Male-E Ref.4 (identifier: Q8IN81-12)

Also known as: G;

The sequence of this isoform differs from the canonical sequence as follows:
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.
Isoform Male-I Ref.1 (identifier: Q8IN81-2)

The sequence of this isoform differs from the canonical sequence as follows:
     324-336: Missing.
     617-789: RVKCFNIKHD...YHGHANHQLH → SSARHHLSTP...DRLLKLNSSI
     790-955: Missing.
Isoform Type-C Ref.4 (identifier: Q8IN81-8)

Also known as: D;

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     572-766: SAALKLHAED...PPVANNQAYL → VKKSEAFLGS...ITINVGKNSA
     767-955: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier
Sequence conflict5391S → P in AAG28590. Ref.3
Sequence conflict6171H → R in AAG28590. Ref.3
Isoform Type-D Ref.4 (identifier: Q8IN81-9)

Also known as: A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.
     617-617: R → E
     618-955: Missing.
Isoform I (identifier: Q8IN81-13)

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.
     86-94: LPLPPASPR → MLQKNSVRK
Note: No experimental confirmation available.
Isoform J (identifier: Q8IN81-14)

The sequence of this isoform differs from the canonical sequence as follows:
     3-51: Missing.
     52-94: HAHSHYAALD...PLPLPPASPR → SRISRNIDSA...RPPLDALPLW
Isoform K (identifier: Q8IN81-15)

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.
     92-93: SP → MT
     617-796: RVKCFNIKHD...QLHQHPPSAT → SKAWHMRLTF...QQQQHNATSE
     797-955: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 955955Sex determination protein fruitless
PRO_0000046921

Regions

Domain131 – 19666BTB
Zinc finger918 – 94124C2H2-type
Compositional bias34 – 5623His-rich
Compositional bias77 – 9317Pro-rich
Compositional bias292 – 35766Ala-rich
Compositional bias386 – 42641Asn-rich
Compositional bias799 – 87072Ala/Ser-rich

Natural variations

Alternative sequence1 – 101101Missing in isoform Female-I, isoform Female-A, isoform Type-D, isoform Type-C, isoform Female-B and isoform Female-E. Ref.1 Ref.4
VSP_050497
Alternative sequence1 – 9191Missing in isoform K.
VSP_039396
Alternative sequence1 – 8585Missing in isoform I.
VSP_039397
Alternative sequence3 – 5149Missing in isoform J.
VSP_039398
Alternative sequence52 – 9443HAHSH…PASPR → SRISRNIDSASCLACPTCIT CPTGPAFPICHIRRPPLDAL PLW in isoform J.
VSP_039399
Alternative sequence86 – 949LPLPPASPR → MLQKNSVRK in isoform I.
VSP_039400
Alternative sequence92 – 932SP → MT in isoform K.
VSP_039401
Alternative sequence324 – 33613Missing in isoform Female-I and isoform Male-I. Ref.1
VSP_050498
Alternative sequence572 – 766195SAALK…NQAYL → VKKSEAFLGSTGNKSMHQML LHQAVEAQLKSFQLHYQNEG LDSAMHRLLAQQQQHQEQQQ QHQQQPHHSLGKSQSPAIPS GSAGGSSRKSGRFRANWLYQ FEWLQYDERANTMFCRHCRK WSGELADIRTSFVEGNSNFR LEIVNHHNKCKSHRMCYERE LQEQQQHPMPSGSAGGSSKR RSPEIITINVGKNSA in isoform Type-C. Ref.4
VSP_050499
Alternative sequence617 – 796180RVKCF…PPSAT → SKAWHMRLTFERLSGGCNLH RCKLCGKVVTHIRNHYHVHF PGRFECPLCRATYTRSDNLR THCKFKHPMYNPDTRKFDNL MSSSAVGAAATPTASQLAVA SQAAMAAAAAAAFNAAQQQQ QQQQQQQQHQHQQQQQHQQS QQQQQQQQQSQQQLHALAQQ HMLQLQPQHHQQQQHNATSE in isoform Female-E, isoform K and isoform Male-E. Ref.4
VSP_050500
Alternative sequence617 – 789173RVKCF…NHQLH → SSARHHLSTPLSTSSSASPP PPPFGMHLSAALKREYHPLH YMAAGNGHNGPSALGYGNQG SGNAPNSAGGAGSVAGGVGA GGGAGGATGAAGHNSHHTMS YHNMFTPSRDPGTMWRCRSC GKEVTNRWHHFHSHTAQRSM CPYCPATYSRIDTLRSHLRV KHPDRLLKLNSSI in isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B. Ref.1 Ref.4
VSP_050501
Alternative sequence6171R → E in isoform Type-D. Ref.4
VSP_050502
Alternative sequence618 – 955338Missing in isoform Type-D. Ref.4
VSP_050503
Alternative sequence767 – 955189Missing in isoform Type-C. Ref.4
VSP_050504
Alternative sequence790 – 955166Missing in isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B. Ref.1 Ref.4
VSP_050505
Alternative sequence797 – 955159Missing in isoform Female-E, isoform K and isoform Male-E. Ref.4
VSP_050506

Experimental info

Sequence conflict931P → PSLQIS in ABC86512. Ref.6
Sequence conflict1071C → S in AAA50838. Ref.8
Sequence conflict1311C → R in BAA12664. Ref.3
Sequence conflict212 – 2187RGLTDNN → CANQGSI in AAA50838. Ref.8
Sequence conflict722 – 7232RA → QRN in AAB92662. Ref.2
Sequence conflict722 – 7232RA → QRN in BAA12663. Ref.3
Sequence conflict722 – 7232RA → QRN in BAA12664. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform Male-A (E) [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: E2A6005D5A7FB7B7

FASTA955102,880
        10         20         30         40         50         60 
MMATSQDYFG NPYALFRGPP TTLRPRESPL GVGHPHGHGH LHSHAHAHGH GHAHSHYAAL 

        70         80         90        100        110        120 
DLQTPHKRNI ETDVRAPPPP LPPPPLPLPP ASPRYNTDQG AMDQQFCLRW NNHPTNLTGV 

       130        140        150        160        170        180 
LTSLLQREAL CDVTLACEGE TVKAHQTILS ACSPYFETIF LQNQHPHPII YLKDVRYSEM 

       190        200        210        220        230        240 
RSLLDFMYKG EVNVGQSSLP MFLKTAESLQ VRGLTDNNNL NYRSDCDKLR DSAASSPTGR 

       250        260        270        280        290        300 
GPSNYTGGLG GAGGVADAMR ESRDSLRSRC ERDLRDELTQ RSSSSMSERS SAAAAAAAAA 

       310        320        330        340        350        360 
AAVAAAGGNV NAAAVALGLT TPTGGERSPS VGSASAAAAA AAVAAAVAAA ANRSASADGC 

       370        380        390        400        410        420 
SDRGSERGTL ERTDSRDDLL QLDYSNKDNN NSNSSSTGGN NNNNNNNNNN SSSNNNNSSS 

       430        440        450        460        470        480 
NRERNNSGER ERERERERER DRDRELSTTP VEQLSSSKRR RKNSSSNCDN SLSSSHQDRH 

       490        500        510        520        530        540 
YPQDSQANFK SSPVPKTGGS TSESEDAGGR HDSPLSMTTS VHLGGGGGNV GAASALSGLS 

       550        560        570        580        590        600 
QSLSIKQELM DAQQQQQHRE HHVALPPDYL PSAALKLHAE DMSTLLTQHA LQAADARDEH 

       610        620        630        640        650        660 
NDAKQLQLDQ TDNIDGRVKC FNIKHDRHPD RELDRNHREH DDDPGVIEEV VVDHVREMEA 

       670        680        690        700        710        720 
GNEHDPEEMK EAAYHATPPK YRRAVVYAPP HPDEEAASGS GSDIYVDGGY NCEYKCKELN 

       730        740        750        760        770        780 
MRAIRCSRQQ HMMSHYSPHH PHHRSLIDCP AEAAYSPPVA NNQAYLASNG AVQQLDLSTY 

       790        800        810        820        830        840 
HGHANHQLHQ HPPSATHPSH SQSSPHYPSA SGAGAGAGSV SVSIAGSASG SATSAPASVA 

       850        860        870        880        890        900 
TSAVSPQPSS SSTGSTSSAA AVAAAAAAAA NRRDHNIDYS TLFVQLSGTL PTLYRCVSCN 

       910        920        930        940        950 
KIVSNRWHHA NIHRPQSHEC PVCGQKFTRR DNMKAHCKIK HADIKDRFFS HYVHM

« Hide

Isoform Female-A (C) (L) (M) [UniParc].

Checksum: 3586E2B2CD274996
Show »

FASTA85491,936
Isoform Female-B (F) [UniParc].

Checksum: 66338CF48C6BF42C
Show »

FASTA68873,094
Isoform Female-E (H) [UniParc].

Checksum: 28B9F9BD279B2DB1
Show »

FASTA69575,537
Isoform Female-I [UniParc].

Checksum: E4772F505C0B0577
Show »

FASTA67571,950
Isoform Male-B (B) [UniParc].

Checksum: 7F87220F6C723A29
Show »

FASTA78984,038
Isoform Male-E (G) [UniParc].

Checksum: DB9F4F6F30170AD8
Show »

FASTA79686,481
Isoform Male-I [UniParc].

Checksum: BE4560B1E0DF6297
Show »

FASTA77682,895
Isoform Type-C (D) [UniParc].

Checksum: 2235D16063D4444C
Show »

FASTA66572,365
Isoform Type-D (A) [UniParc].

Checksum: E91B5D22099FF65B
Show »

FASTA51655,086
Isoform I [UniParc].

Checksum: 4F1911F85760770A
Show »

FASTA87093,771
Isoform J [UniParc].

Checksum: A740B79FB6699DB6
Show »

FASTA90697,595
Isoform K [UniParc].

Checksum: F2D99E279741D9EE
Show »

FASTA70576,675

References

« Hide 'large scale' references
[1]"Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene."
Ryner L.C., Goodwin S.F., Castrillon D.H., Anand A., Villella A., Baker B.S., Hall J.C., Taylor B.J., Wasserman S.A.
Cell 87:1079-1089(1996) [PubMed: 8978612] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MALE-I AND FEMALE-I), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TRA, DISRUPTION PHENOTYPE.
Strain: Oregon-R.
[2]"Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain."
Ito H., Fujitani K., Usui K., Shimizu-Nishikawa K., Tanaka S., Yamamoto D.
Proc. Natl. Acad. Sci. U.S.A. 93:9687-9692(1996) [PubMed: 8790392] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FEMALE-A), FUNCTION, TISSUE SPECIFICITY.
Strain: Canton-S.
Tissue: Head.
[3]"Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression."
Usui-Aoki K., Ito H., Ui-Tei K., Takahashi K., Lukacsovich T., Awano W., Nakata H., Piao Z.F., Nilsson E.E., Tomida J.-Y., Yamamoto D.
Nat. Cell Biol. 2:500-506(2000) [PubMed: 10934470] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS MALE-A; FEMALE-A; MALE-B; FEMALE-B; TYPE-C; TYPE-D; MALE-E AND FEMALE-E), FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH TRA.
Strain: Canton-S.
Tissue: Head.
[4]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[5]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
Strain: Berkeley.
[6]Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MALE-A).
Strain: Berkeley.
Tissue: Head.
[7]"Genomic structure of the fruitless gene in Drosophila melanogaster."
Davis T., Ito H.
Dros. Info. Service 84:65-66(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-210 (ISOFORMS J AND FEMALE-I/FEMALE-A/TYPE-D/TYPE-C/FEMALE-B/FEMALE-E).
[8]"The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila."
Zollman S., Godt D., Prive G.G., Couderc J.-L., Laski F.A.
Proc. Natl. Acad. Sci. U.S.A. 91:10717-10721(1994) [PubMed: 7938017] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 104-218.
[9]"Regulation of sex-specific selection of fruitless 5' splice sites by transformer and transformer-2."
Heinrichs V., Ryner L.C., Baker B.S.
Mol. Cell. Biol. 18:450-458(1998) [PubMed: 9418892] [Abstract]
Cited for: FUNCTION.
[10]"The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior."
Dauwalder B., Tsujimoto S., Moss J., Mattox W.
Genes Dev. 16:2879-2892(2002) [PubMed: 12435630] [Abstract]
Cited for: FUNCTION.
Strain: Canton-S.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF039231 mRNA. Translation: AAB96677.1.
U72492 mRNA. Translation: AAB92662.1.
D84437 mRNA. Translation: BAA12663.1.
D84438 mRNA. Translation: BAA12664.1.
AF220176 mRNA. Translation: AAG28587.1.
AF220177 mRNA. Translation: AAG28588.1.
AF220178 mRNA. Translation: AAG28589.1.
AF220179 mRNA. Translation: AAG28590.1.
AF220180 mRNA. Translation: AAG28591.1.
AF220181 mRNA. Translation: AAG28592.1.
AE014297 Genomic DNA. Translation: AAF55562.2.
AE014297 Genomic DNA. Translation: AAF55563.2.
AE014297 Genomic DNA. Translation: AAF55564.2.
AE014297 Genomic DNA. Translation: AAF55565.2.
AE014297 Genomic DNA. Translation: AAN13774.1.
AE014297 Genomic DNA. Translation: AAN13775.1.
AE014297 Genomic DNA. Translation: AAN13776.1.
AE014297 Genomic DNA. Translation: AAN13777.1.
AE014297 Genomic DNA. Translation: AAS65172.1.
AE014297 Genomic DNA. Translation: AAS65173.1.
AE014297 Genomic DNA. Translation: AAS65174.1.
AE014297 Genomic DNA. Translation: AAS65175.1.
AE014297 Genomic DNA. Translation: AAS65176.1.
BT024450 mRNA. Translation: ABC86512.1.
AY152837 mRNA. Translation: AAN74532.1.
AY152838 mRNA. Translation: AAN74533.1.
U14403 Genomic DNA. Translation: AAA50838.1.
RefSeqNP_001163648.1. NM_001170177.1.
NP_524397.2. NM_079673.2.
NP_732344.1. NM_169816.1.
NP_732345.1. NM_169817.1.
NP_732346.1. NM_169818.1.
NP_732347.1. NM_169819.1.
NP_732348.1. NM_169820.1.
NP_732349.1. NM_169821.1.
NP_732350.1. NM_169822.1.
NP_996234.1. NM_206512.1.
NP_996235.1. NM_206513.1.
NP_996236.1. NM_206514.1.
NP_996237.1. NM_206515.1.
NP_996238.1. NM_206516.1.
UniGeneDm.4626.

3D structure databases

ProteinModelPortalQ8IN81.
SMRQ8IN81. Positions 107-218, 883-941.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-17120N.
IntActQ8IN81. 1 interaction.
MINTMINT-773162.
STRINGQ8IN81.

Proteomic databases

PRIDEQ8IN81.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0083643; FBpp0083063; FBgn0004652.
GeneID42226.
KEGGdme:Dmel_CG14307.
UCSCCG14307-RA. d. melanogaster.

Organism-specific databases

CTD42226.
FlyBaseFBgn0004652. fru.

Phylogenomic databases

eggNOGNOG146019.
GeneTreeENSGT00530000064321.
InParanoidQ8IN81.
OMAIDGSKAW.
OrthoDBEOG479CQQ.
PhylomeDBQ8IN81.

Gene expression databases

BgeeA4V334.
GermOnlineCG14307. Drosophila melanogaster.

Family and domain databases

Gene3DG3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00651. BTB. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMSSF54695. BTB/POZ_fold. 1 hit.
PROSITEPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio827755.

Entry information

Entry nameFRU_DROME
AccessionPrimary (citable) accession number: Q8IN81
Secondary accession number(s): A4V334 expand/collapse secondary AC list , O44708, P91618, P91619, Q24004, Q29QE0, Q7KSD2, Q7KSD5, Q7KSD6, Q8IN80, Q8IN82, Q8IN83, Q8IS35, Q8IS36, Q9GU18, Q9GU19, Q9GU20, Q9GU21, Q9GU22, Q9VE64, Q9VE65, Q9VE66, Q9VE67
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: April 18, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Recent format changes

Overview of recent format changes

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

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