Unreviewed, UniProtKB/TrEMBL Q8IN02 (Q8IN02_DROME)

Names and origin

Protein names

Recommended name:
    Diphthine synthase RuleBase RU003961V0
    EC=2.1.1.98

Gene names

Name:	Dph5 EMBL AAN13913.2 FlyBase FBgn0024558
Synonyms:	BcDNA.LD12153 EMBL AAD46869.1
ORF Names:	CG31289 FlyBase FBgn0024558, Dmel_CG31289 EMBL AAN13913.2

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for the methylation step in diphthamide biosynthesis By similarity. RuleBase RU003961V0
Catalytic activity	S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. RuleBase RU003961V0
Pathway	Protein modification; diphthamide biosynthesis. RuleBase RU003961V0
Sequence similarities	Belongs to the diphthine synthase family. RuleBase RU003961V0

Ontologies

Keywords
Molecular function	Methyltransferase RuleBase RU003961V0 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	peptidyl-diphthamide biosynthetic process from peptidyl-histidine Inferred from electronic annotation. Source: InterPro
Molecular function	diphthine synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IN02-1 [UniParc]. Last modified June 1, 2003. Version 2. Checksum: 3B2C3EEB2C1D7541	FASTA	281	31,620
	10 20 30 40 50 60 MFYLIGLGLG DLKDITVKGL EIVKQCSRVY LEMYTSILGC SLEDMQEFYG RPLLLADRDL 70 80 90 100 110 120 VEQGADEILA GAGESDVALL VVGDPFGATT HTDFILRAKE KNIPYKVIHN ASIMNAVGCC 130 140 150 160 170 180 GLQLYKFGET VSIPYWDETW KPDSFYDKIK LNRLHNMHTL CLLDIKVKEP TPESLMRKRK 190 200 210 220 230 240 EYMPPRFMTV AEAAHQLLSI VEKKDSLEKN TVLNEQSLCV GLARVGQESQ QIAVGTLLEM 250 260 270 280 RSTDLGGPLH SLIIPAKEMH PLEVEFLQQY APSIKLDDYN H

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Full Length Drosophila melanogaster cDNA sequence." Tsang G., Brokstein P., Frise E., Harvey D., Evans-Holm M., Lewis S.E., Suh C., Rubin G.M. Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF160929 mRNA. Translation: AAD46869.1. AE014297 Genomic DNA. Translation: AAN13913.2.
RefSeq	NP_524452.4.
UniGene	Dm.2376
3D structure databases
HSSP	HSSP built from PDB template 1VHV based on UniProtKB O29866.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8IN02. 1 interaction.
Genome annotation databases
Ensembl	FBgn0024558. Drosophila melanogaster. [Contig view]
GeneID	42663.
KEGG	dme:Dmel_CG31289.
NMPDR	fig|7227.3.peg.14099.
Organism-specific databases
FlyBase	FBgn0024558. Dph5.
Phylogenomic databases
HOGENOM	Q8IN02.
OMA	Q8IN02. GATTHTD.
Gene expression databases
ArrayExpress	Q8IN02.
Family and domain databases
InterPro	IPR000878. 4pyrrol_Mease. IPR014777. 4pyrrole_Mease_sub1. IPR014776. 4pyrrole_Mease_sub2. IPR004551. Dphthn_synthase. [Graphical view]
Gene3D	G3DSA:3.40.1010.10. 4pyrrole_Mease_sub1. 1 hit. G3DSA:3.30.950.10. 4pyrrole_Mease_sub2. 1 hit.
PANTHER	PTHR10882. Dphthn_synthase. 1 hit.
Pfam	PF00590. TP_methylase. 1 hit. [Graphical view]
PIRSF	PIRSF036432. Diphthine_synth. 1 hit.
TIGRFAMs	TIGR00522. dph5. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	829950.

Entry information

Entry name

Q8IN02_DROME

Accession

Primary (citable) accession number: Q8IN02

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	June 1, 2003
Last modified:	July 7, 2009
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)