Q8IMF8 (Q8IMF8_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hephaestus, isoform C EMBL AAN14296.1

Submitted name:
Hephaestus, isoform S EMBL ACZ95084.1
Submitted name:
Hephaestus, isoform T EMBL ACZ95085.1
Submitted name:
Hephaestus, isoform U EMBL ACZ95086.1
Submitted name:
Polypyrimidine tract binding protein EMBL AAF22979.1

Gene names

Name:	heph FlyBase FBgn0011224 EMBL AAN14296.1
Synonyms:	PTB EMBL AAF22979.1
ORF Names:	CG31000 FlyBase FBgn0011224, Dmel_CG31000 EMBL AAN14296.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	581 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	imaginal disc-derived wing margin morphogenesis Inferred from mutant phenotype. Source: FlyBase imaginal disc-derived wing vein morphogenesis Inferred from mutant phenotype. Source: FlyBase mRNA processing Inferred from electronic annotation. Source: InterPro negative regulation of oskar mRNA translation Inferred from mutant phenotype. Source: FlyBase oocyte microtubule cytoskeleton polarization Inferred from mutant phenotype. Source: FlyBase sperm individualization Inferred from mutant phenotype. Source: FlyBase
Cellular component	cytoplasm Inferred from direct assay. Source: FlyBase nucleus Inferred from electronic annotation. Source: InterPro ribonucleoprotein complex Inferred from direct assay. Source: FlyBase
Molecular function	mRNA 3'-UTR binding Inferred from direct assay. Source: FlyBase nucleotide binding Inferred from electronic annotation. Source: InterPro translation repressor activity, nucleic acid binding Inferred from mutant phenotype. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IMF8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 331DAEEDD471FD32	FASTA	581	62,560
	10 20 30 40 50 60 MRGSDELLSQ AAVMAPASDN NNQDLATKKA KLEPGTVLAG GIAKASKVIH LRNIPNESGE 70 80 90 100 110 120 ADVIALGIPF GRVTNVLVLK GKNQAFIEMA DEISATSMVS CYTVTPPQMR GRMVYVQFSN 130 140 150 160 170 180 HRELKTDQGH NNSTAHSDYS VQSPASGSPL PLSAAANATS NNANSSSDSN SAMGILQNTS 190 200 210 220 230 240 AVNAGGNTNA AGGPNTVLRV IVESLMYPVS LDILHQIFQR YGKVLKIVTF TKNNSFQALI 250 260 270 280 290 300 QYPDANSAQH AKSLLDGQNI YNGCCTLRID NSKLTALNVK YNNDKSRDFT NPALPPGEPG 310 320 330 340 350 360 VDIMPTAGGL MNTNDLLLIA ARQRPSLSGD KIVNGLGAPG VLPPFALGLG TPLTGGYNNA 370 380 390 400 410 420 LPNLAAFSLA NSGALQTTAP AMRGYSNVLL VSNLNEEMVT PDALFTLFGV YGDVQRVKIL 430 440 450 460 470 480 YNKKDSALIQ MAEPQQAYLA MSHLDKLRLW GKPIRVMASK HQAVQLPKEG QPDAGLTRDY 490 500 510 520 530 540 SQNPLHRFKK PGSKNYQNIY PPSATLHLSN IPSSCSEDDI KEAFTSNSFE VKAFKFFPKD 550 560 570 580 RKMALLQLLS VEEAVLALIK MHNHQLSESN HLRVSFSKSN I

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Release 5.1 annotation of Drosophila melanogaster heterochromatin." Smith C.D., Shu S., Mungall C.J., Karpen G.H. Science 316:1586-1591(2007) [PubMed: 17569856] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Sequence finishing and mapping of Drosophila melanogaster heterochromatin." Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., Dimitri P., Karpen G.H., Celniker S.E. Science 316:1625-1628(2007) [PubMed: 17569867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Lineage-specific expression of polypyrimidine tract binding protein (PTB) in Drosophila embryos." Davis M.B., Sun W., Standiford D.M. Mech. Dev. 111:143-147(2002) [PubMed: 11804786] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Combined evidence annotation of transposable elements in genome sequences." Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D. PLoS Comput. Biol. 1:166-175(2005) [PubMed: 16110336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[7]	"Heterochromatic sequences in a Drosophila whole-genome shotgun assembly." Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H. Genome Biol. 3:RESEARCH0085.1-RESEARCH0085.16(2002) [PubMed: 12537574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[8]	"The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective." Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J.W., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E. Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed: 12537573] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[9]	"Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence." Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., Pacleb J.M., Park S. , Pfeiffer B.D., Richards S., Sodergren E.J., Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M. Genome Biol. 3 (12), RESEARCH0079 (2002) Cited for: NUCLEOTIDE SEQUENCE.
[10]	Drosophila Heterochromatin Genome Project Smith C.D., Shu S., Mungall C.J., Karpen G.H. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[11]	FlyBase Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[12]	"Drosophila melanogaster release 4 sequence." Berkeley Drosophila Genome Project Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[13]	Celniker S., Carlson J., Kennedy C., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Karpen G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[14]	Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G. Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF211191 mRNA. Translation: AAF22979.1. AE014297 Genomic DNA. Translation: AAN14296.1. AE014297 Genomic DNA. Translation: ACZ95084.1. AE014297 Genomic DNA. Translation: ACZ95085.1. AE014297 Genomic DNA. Translation: ACZ95086.1.
RefSeq	NP_001163791.1. NM_001170320.1. NP_001163792.1. NM_001170321.1. NP_001163793.1. NM_001170322.1. NP_524703.1. NM_079964.3.
UniGene	Dm.19417.
3D structure databases
HSSP	HSSP built from PDB template 1QM9 based on UniProtKB P26599.
ProteinModelPortal	Q8IMF8.
SMR	Q8IMF8. Positions 40-128, 192-298, 386-581.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IMF8.
Proteomic databases
PRIDE	Q8IMF8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0085880; FBpp0085239; FBgn0011224. FBtr0300267; FBpp0289495; FBgn0011224. FBtr0300268; FBpp0289496; FBgn0011224. FBtr0300269; FBpp0289497; FBgn0011224.
GeneID	48571.
KEGG	dme:Dmel_CG31000.
UCSC	CG31000-RC. d. melanogaster.
Organism-specific databases
CTD	9843.
FlyBase	FBgn0011224. heph.
Phylogenomic databases
GeneTree	EMGT00050000000537.
InParanoid	Q8IMF8.
PhylomeDB	Q8IMF8.
Gene expression databases
ArrayExpress	Q8IMF8.
Bgee	Q8IMF8.
Family and domain databases
InterPro	IPR006536. HnRNP-L_PTB. IPR012677. Nucleotide-bd_a/b_plait. IPR000504. RRM_dom. [Graphical view]
Gene3D	G3DSA:3.30.70.330. a_b_plait_nuc_bd. 4 hits.
KO	K14948.
Pfam	PF00076. RRM_1. 2 hits. [Graphical view]
SMART	SM00360. RRM. 4 hits. [Graphical view]
TIGRFAMs	TIGR01649. HnRNP-L_PTB. 1 hit.
PROSITE	PS50102. RRM. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	839481.

Entry information

Entry name

Q8IMF8_DROME

Accession

Primary (citable) accession number: Q8IMF8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)