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Protein
Submitted name:

Pfprex

Gene

POM1

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • 3'-5' exonuclease activity Source: GeneDB
  • ATP binding Source: InterPro
  • DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: GeneDB
  • DNA helicase activity Source: GeneDB
  • DNA primase activity Source: GeneDB
  • zinc ion binding Source: InterPro

Keywordsi

Molecular functionNucleotidyltransferaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
PfprexImported
Submitted name:
Plastid replication-repair enzymeImported (EC:2.7.7.7Imported)
Gene namesi
Name:POM1Imported
ORF Names:PF14_0112Imported, PF3D7_1411400Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1411400.

Subcellular locationi

GO - Cellular componenti

  • apicoplast Source: GeneDB

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501014620120 – 2016Sequence analysisAdd BLAST1997

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DKTX-ray2.90A1389-2016[»]
5DKUX-ray2.90A/B1389-2016[»]
SMRiQ8ILY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini379 – 463ToprimInterPro annotationAdd BLAST85
Domaini685 – 934SF4 helicaseInterPro annotationAdd BLAST250

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili310 – 351Sequence analysisAdd BLAST42
Coiled coili581 – 601Sequence analysisAdd BLAST21
Coiled coili1649 – 1694Sequence analysisAdd BLAST46

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000281341.
InParanoidiQ8ILY1.
KOiK02335.
K17680.
OMAiNYPVQGT.

Family and domain databases

CDDicd01029. TOPRIM_primases. 1 hit.
Gene3Di3.30.420.10. 1 hit.
3.90.580.10. 1 hit.
InterProiView protein in InterPro
IPR002562. 3'-5'_exonuclease_dom.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR007694. DNA_helicase_DnaB-like_C.
IPR002298. DNA_polymerase_A.
IPR036977. DNA_primase_Znc.
IPR027417. P-loop_NTPase.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
IPR034154. TOPRIM_DnaG/twinkle.
IPR006171. TOPRIM_domain.
PfamiView protein in Pfam
PF00476. DNA_pol_A. 1 hit.
PF01612. DNA_pol_A_exo1. 1 hit.
PRINTSiPR00868. DNAPOLI.
SMARTiView protein in SMART
SM00474. 35EXOc. 1 hit.
SM00482. POLAc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53098. SSF53098. 1 hit.
PROSITEiView protein in PROSITE
PS51199. SF4_HELICASE. 1 hit.
PS50880. TOPRIM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ILY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLYKFYFLY FLLVHLSLCI RYRNQNKTDS YLKTNYKLLK KRKKYENRRY
60 70 80 90 100
KFPKNRKGNN NNIYDAINNN NTNNIYNNDT YKNRIFFRNE KNDENFIKTN
110 120 130 140 150
KYSYYEKRNK IKLNSATSTF VSKYYKININ DVYNYLHRKK YEFIETDIKI
160 170 180 190 200
TLKYCPFCPP HKYKYDNMYK HEIFKNTGNS YCHRCGYKGS FYDFKLKMGD
210 220 230 240 250
LITSNFESTV VHNNNFYEEE EEKITLNDVK VYNMNLLYSK EAENARNYLM
260 270 280 290 300
NVRKLSIDTL KKFLIGFSVM EFQSFESSGK FEKHECIIFP FIKKVDEINM
310 320 330 340 350
IETNGINSNM NKMNNNNNNN NNNNNNNNNN NNNINDNYEV VRIKIRSLKD
360 370 380 390 400
KGYMRLYPKN VRNEMKLFFF GDHLIKNSEE IVLTEGEIDA MTISQETKYP
410 420 430 440 450
AISLPNGSKS LPIYLLPYLE RFKKIHLWLD FDKAGKSSVF NFVNKIGLGR
460 470 480 490 500
TNVITDANVH YLNPDVFKRR QKSRLTKKSL LLTSMASNAM EILQKDKEEN
510 520 530 540 550
MHNIYDTTNN DYMDNKILSN NLKSISSDKI KKKEEIDLFN GQKISSNNIN
560 570 580 590 600
VNILKNKKNE TDNITNKENK SDNNLKEGME KKEIQNEISV IEDNNNNKNN
610 620 630 640 650
IIENNNDDMS EKIKVEKSIE DNISYFVDNN IMYIPNNIII KDANDCLKHN
660 670 680 690 700
IDIRFFIETS EKVKHSQILN FNDLRQRILE ELKYPDRING VKSKTIPSLN
710 720 730 740 750
KYLYGLRMGE LSIWTGSTGV GKTTLLSQLS LDYCIQGVST LWGSFEINNV
760 770 780 790 800
KLGKVMLNQF CGKNLEKNIE LFDIYADKFE LLPLKFLKFH GSTNIDQVID
810 820 830 840 850
AMDYAVYAYD VKHIIIDNLQ FMLNINKFSD IYELQNIAID KFRSFSTNKN
860 870 880 890 900
VHITLVVHPR KEDNNLLSIS SVFGSVKSTQ EADNVFIIQR HVSKTNETVF
910 920 930 940 950
FIDIKKNRFK GSLGKIPYLY NKENMTIKEI SINNFNEHVV SNTYLPSNKF
960 970 980 990 1000
SSSSLQNNTT NNNFIQNDNL NFTLCDEYDY MKQLADEYES KHAFKKGYRS
1010 1020 1030 1040 1050
KLDPNLRVNN IDMIKTEIID NSDMNNNKNV TLYVDSLENI KTISTDDKTN
1060 1070 1080 1090 1100
DDKRDVNEIK SIKNNERKNT LKIDGNKSLG STQNLNYENE NKNNNNNNNN
1110 1120 1130 1140 1150
NKSNQEMEKN NIDDKSSTGN NKNINGNSKG NNNINNNNKN KNSSSSSSSS
1160 1170 1180 1190 1200
SNYNNNEGIK NILNTSAQNN IPFKDTIWSY TLTNEGLIKL CEELKDEEAE
1210 1220 1230 1240 1250
KLKNRVVVLS MRNCIIDNNS SIKDIRTFIK TNKLNIKTAG KNLKKMDIFI
1260 1270 1280 1290 1300
SILQNIPKEY ITIKSGQKYG PNKGLPNDKS KNKIKEPHNN NMLEYNKVGS
1310 1320 1330 1340 1350
NIGDGQNTSS SCMNINKIYS EEENNIYINN NNNNMNKEPQ TLLPNDRNDS
1360 1370 1380 1390 1400
NSHSYNNINY TMVKNGNEGN INDYLNRNYE NNVDNHHNDE ITKKYIKDNI
1410 1420 1430 1440 1450
INVDDNIIKK KDIFKLKNEN NEITECAFEY FESKKKFDDD IESRFFIIND
1460 1470 1480 1490 1500
NNYNENINLI YKDIKYCGLD IETTGLEVFD ENIRLIQIAV ENYPVIIYDM
1510 1520 1530 1540 1550
FNINKKDILD GLRKVLENKN IIKIIQNGKF DAKFLLHNNF KIENIFDTYI
1560 1570 1580 1590 1600
ASKLLDKNKN MYGFKLNNIV EKYLNVILDK QQQNSVWNNS LLNNNQLFYA
1610 1620 1630 1640 1650
ARDSSCLLKL YKKLKEEIKK ENLHIVNDIE NKCILPICDM ELNGIKVDLE
1660 1670 1680 1690 1700
NLQKSTNEIL NELNIEKDNL KKKLKDENIN VNSQQQVLKA LQKNNVRDIS
1710 1720 1730 1740 1750
NKLIENTSDS NLKNFLNHEE IISLRNYRRL YKLYSAFYLK LPLHINTKTN
1760 1770 1780 1790 1800
KIHTTFNQLK TFSGRFSSEK PNLQQIPRQK NIREIFIPND NNIFIIADFK
1810 1820 1830 1840 1850
QIELKIAAEI TNDEIMLKAY NNNIDLHTLT ASIITKKNIP DINKEDRHIA
1860 1870 1880 1890 1900
KAINFGLIYG MNYVNLKNYA NTYYGLNMSL DQCLYFYNSF FEHYKGIYKW
1910 1920 1930 1940 1950
HNQVKQKRAL QYSTLSNRKV IFPYFSFTKA LNYPVQGTCA DILKLALVDL
1960 1970 1980 1990 2000
YDNLKDINGK IILCVHDEII IEVNKKFQEE ALKILVQSME NSASYFLKKV
2010
KCEVSVKIAE NWGSKD
Length:2,016
Mass (Da):235,818
Last modified:March 1, 2003 - v1
Checksum:i271C80CEA1FB865D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN36724.1.
LN999946 Genomic DNA. Translation: CZT99824.1.
RefSeqiXP_001348285.1. XM_001348249.2.

Genome annotation databases

EnsemblProtistsiCZT99824; CZT99824; PF3D7_1411400.
GeneDBiPF3D7_1411400.1:pep.
GeneIDi811693.
KEGGipfa:PF14_0112.

Similar proteinsi

Entry informationi

Entry nameiQ8ILY1_PLAF7
AccessioniPrimary (citable) accession number: Q8ILY1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported