Q8ILW6 (NMT_PLAF7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycylpeptide N-tetradecanoyltransferase
EC=2.3.1.97

Alternative name(s):
Myristoyl-CoA:protein N-myristoyltransferase
Short name=NMT
Peptide N-myristoyltransferase

Gene names

ORF Names:

PF14_0127

Organism

Plasmodium falciparum (isolate 3D7)

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	410 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins By similarity.
Catalytic activity	Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the NMT family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	N-terminal protein myristoylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycylpeptide N-tetradecanoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 410	410	Glycylpeptide N-tetradecanoyltransferase		PRO_0000064230

Sequences

	Sequence		Length	Mass (Da)
	Q8ILW6 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: AA823DD100D80C10	FASTA	410	47,970
	10 20 30 40 50 60 MNDDKKDFVG RDLYQLIRNA KDKIKIDYKF WYTQPVPKIN DEFDENVNEP FISDNKVEDV 70 80 90 100 110 120 RKEEYKLPSG YAWCVCDITK ENDRSDIYNL LTDNYVEDDD NVFRFNYSSE FLLWALSSPN 130 140 150 160 170 180 YVKNWHIGVK YESTNKLVGF ISAIPIDMCV NKNIIKMAEV NFLCVHKSLR SKRLAPVLIK 190 200 210 220 230 240 EITRRINLES IWQAIYTAGV YLPKPISTAR YFHRSINVKK LIEIGFSCLN TRLTMSRAIK 250 260 270 280 290 300 LYRIDDTLNI KNLRLMKKKD IDGLQKLLNE HLKQYNLHAI FSKEDVAHWF TPIDQVIYTY 310 320 330 340 350 360 VNEENGEIKD LISFYSLPSK VLGNNKYNIL NAAFSFYNIT TTTTFKNLIQ DAICLAKRNN 370 380 390 400 410 FDVFNALEVM DNYSVFQDLK FGEGDGSLKY YLYNWKCASC HPSKIGIVLL

References

[1]

"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed: 12368864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014187 Genomic DNA. Translation: AAN36739.1.
RefSeq	XP_001348300.1. XM_001348264.1.
3D structure databases
ProteinModelPortal	Q8ILW6.
SMR	Q8ILW6. Positions 70-409.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	PF14_0127:mRNA; PF14_0127:pep; PF14_0127.
GeneID	811708.
KEGG	pfa:PF14_0127.
NMPDR	fig|36329.1.peg.2002.
Organism-specific databases
EuPathDB	EupathDB:PF14_0127.
Phylogenomic databases
GeneTree	EPrGT00050000005374.
HOGENOM	HBG314670.
OMA	EHAKGSP.
ProtClustDB	CLSZ2428978.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR000903. MyristoylCoA_TrFase. IPR022677. MyristoylCoA_TrFase_C. IPR022678. MyristoylCoA_TrFase_CS. IPR022676. MyristoylCoA_TrFase_N. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 2 hits.
KO	K00671.
PANTHER	PTHR11377. Myristoyl_trans. 1 hit.
Pfam	PF01233. NMT. 1 hit. PF02799. NMT_C. 1 hit. [Graphical view]
PIRSF	PIRSF015892. N-myristl_transf. 1 hit.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 2 hits.
PROSITE	PS00975. NMT_1. 1 hit. PS00976. NMT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NMT_PLAF7

Accession

Primary (citable) accession number: Q8ILW6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)