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Protein

Uracil-DNA glycosylase

Gene

PF14_0148

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169Proton acceptorUniRule annotation1

GO - Molecular functioni

  • uracil DNA N-glycosylase activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionGlycosidaseImported, Hydrolase
Biological processDNA damage, DNA repairUniRule annotation

Enzyme and pathway databases

ReactomeiR-PFA-110329. Cleavage of the damaged pyrimidine.
R-PFA-110357. Displacement of DNA glycosylase by APEX1.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
ORF Names:PF14_0148Imported, PF3D7_1415000Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1415000.

Subcellular locationi

  • Mitochondrion UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MitochondrionUniRule annotation, NucleusUniRule annotation

Structurei

3D structure databases

SMRiQ8ILU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 308UDGInterPro annotationAdd BLAST155

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229528.
InParanoidiQ8ILU6.
KOiK03648.
OMAiDNGYLMP.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiView protein in InterPro
IPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
IPR036895. Uracil-DNA_glycosylase-like_sf.
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiView protein in Pfam
PF03167. UDG. 1 hit.
SMARTiView protein in SMART
SM00986. UDG. 1 hit.
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiView protein in PROSITE
PS00130. U_DNA_GLYCOSYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ILU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNPTIQKTI DQFFKVKRKS SILSGEIEKK RKKVILEEVE EKSLEGSLKE
60 70 80 90 100
ENVNILKTKK LMNNDEDIEK MGTISNISMS TSTIDNEINN NVKQNVCEQG
110 120 130 140 150
YMEEIKKLMH IEWYELLKDE LKKNYFKNMY LKIKEERKTK VIYPPEQLVF
160 170 180 190 200
NAFLKTPLSN IKVVIVGQDP YHQKDQAMGL CFSVPIGVKI PPSLKNILKE
210 220 230 240 250
MKQKSNHGNL ISWSEQGVFL LNTSLTVEEN KPASHKNYGW ETFTDTVINI
260 270 280 290 300
INRQKEKIIF MLWGNFAIKK CKNIDINKHF ILKAGHPSPL SIKHFENCNH
310 320
FAKCNKILAQ HNLTPIKWEL PQ
Length:322
Mass (Da):37,461
Last modified:March 1, 2003 - v1
Checksum:iDF9AF469A2098C38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN36760.1.
LN999946 Genomic DNA. Translation: CZT99861.1.
RefSeqiXP_001348321.1. XM_001348285.1.

Genome annotation databases

EnsemblProtistsiCZT99861; CZT99861; PF3D7_1415000.
GeneDBiPF3D7_1415000.1:pep.
GeneIDi811729.
KEGGipfa:PF14_0148.

Similar proteinsi

Entry informationi

Entry nameiQ8ILU6_PLAF7
AccessioniPrimary (citable) accession number: Q8ILU6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported