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Protein

Glutathione S-transferase

Gene

GST

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1

GO - Molecular functioni

  • glutathione transferase activity Source: GeneDB

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Gene namesi
Name:GST
ORF Names:PF14_0187
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1419300

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002599671 – 211Glutathione S-transferaseAdd BLAST211

Proteomic databases

PRIDEiQ8ILQ7

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8ILQ7
SMRiQ8ILQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 87GST N-terminalAdd BLAST85
Domaini89 – 211GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 59Glutathione bindingBy similarity2
Regioni71 – 72Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily.Curated

Phylogenomic databases

HOGENOMiHOG000115733
InParanoidiQ8ILQ7
KOiK00799
OMAiQKEVVSM
PhylomeDBiQ8ILQ7

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF14497 GST_C_3, 1 hit
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q8ILQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDNIVLYYF DARGKAELIR LIFAYLGIEY TDKRFGVNGD AFVEFKNFKK
60 70 80 90 100
EKDTPFEQVP ILQIGDLILA QSQAIVRYLS KKYNICGESE LNEFYADMIF
110 120 130 140 150
CGVQDIHYKF NNTNLFKQNE TTFLNEDLPK WSGYFEKLLK KNHTNNNNDK
160 170 180 190 200
YYFVGNNLTY ADLAVFNLYD DIETKYPSSL KNFPLLKAHN EFISNLPNIK
210
NYITNRKESV Y
Length:211
Mass (Da):24,789
Last modified:March 1, 2003 - v1
Checksum:iEDC79583CFC9D751
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA Translation: AAN36799.1
RefSeqiXP_001348360.1, XM_001348324.1

Genome annotation databases

GeneDBiPF3D7_1419300.1:pep
GeneIDi811768
KEGGipfa:PF14_0187

Similar proteinsi

Entry informationi

Entry nameiGST_PLAF7
AccessioniPrimary (citable) accession number: Q8ILQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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