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Q8ILQ7

- GST_PLAF7

UniProt

Q8ILQ7 - GST_PLAF7

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Protein
Glutathione S-transferase
Gene
GST, PF14_0187
Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91Glutathione By similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase (EC:2.5.1.18)
Gene namesi
Name:GST
ORF Names:PF14_0187
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1419300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 211211Glutathione S-transferase
PRO_0000259967Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi5833.PF14_0187-1.

Structurei

3D structure databases

ProteinModelPortaliQ8ILQ7.
SMRiQ8ILQ7. Positions 1-211.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8785GST N-terminal
Add
BLAST
Domaini89 – 211123GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 592Glutathione binding By similarity
Regioni71 – 722Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily.

Phylogenomic databases

HOGENOMiHOG000115733.
KOiK00799.
OMAiNELEPWA.
PhylomeDBiQ8ILQ7.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ILQ7-1 [UniParc]FASTAAdd to Basket

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MGDNIVLYYF DARGKAELIR LIFAYLGIEY TDKRFGVNGD AFVEFKNFKK    50
EKDTPFEQVP ILQIGDLILA QSQAIVRYLS KKYNICGESE LNEFYADMIF 100
CGVQDIHYKF NNTNLFKQNE TTFLNEDLPK WSGYFEKLLK KNHTNNNNDK 150
YYFVGNNLTY ADLAVFNLYD DIETKYPSSL KNFPLLKAHN EFISNLPNIK 200
NYITNRKESV Y 211
Length:211
Mass (Da):24,789
Last modified:March 1, 2003 - v1
Checksum:iEDC79583CFC9D751
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014187 Genomic DNA. Translation: AAN36799.1.
RefSeqiXP_001348360.1. XM_001348324.1.

Genome annotation databases

EnsemblProtistsiPF14_0187:mRNA; PF14_0187:pep; PF14_0187.
GeneIDi811768.
KEGGipfa:PF14_0187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014187 Genomic DNA. Translation: AAN36799.1 .
RefSeqi XP_001348360.1. XM_001348324.1.

3D structure databases

ProteinModelPortali Q8ILQ7.
SMRi Q8ILQ7. Positions 1-211.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5833.PF14_0187-1.

Chemistry

BindingDBi Q8ILQ7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi PF14_0187:mRNA ; PF14_0187:pep ; PF14_0187 .
GeneIDi 811768.
KEGGi pfa:PF14_0187.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1419300.

Phylogenomic databases

HOGENOMi HOG000115733.
KOi K00799.
OMAi NELEPWA.
PhylomeDBi Q8ILQ7.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.

Entry informationi

Entry nameiGST_PLAF7
AccessioniPrimary (citable) accession number: Q8ILQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi