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Q8ILQ7 (GST_PLAF7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione S-transferase

EC=2.5.1.18
Gene names
Name:GST
ORF Names:PF14_0187
OrganismPlasmodium falciparum (isolate 3D7) [Reference proteome]
Taxonomic identifier36329 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST C-terminal domain.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211Glutathione S-transferase
PRO_0000259967

Regions

Domain3 – 8785GST N-terminal
Domain89 – 211123GST C-terminal
Region58 – 592Glutathione binding By similarity
Region71 – 722Glutathione binding By similarity

Sites

Binding site91Glutathione By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ILQ7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EDC79583CFC9D751

FASTA21124,789
        10         20         30         40         50         60 
MGDNIVLYYF DARGKAELIR LIFAYLGIEY TDKRFGVNGD AFVEFKNFKK EKDTPFEQVP 

        70         80         90        100        110        120 
ILQIGDLILA QSQAIVRYLS KKYNICGESE LNEFYADMIF CGVQDIHYKF NNTNLFKQNE 

       130        140        150        160        170        180 
TTFLNEDLPK WSGYFEKLLK KNHTNNNNDK YYFVGNNLTY ADLAVFNLYD DIETKYPSSL 

       190        200        210 
KNFPLLKAHN EFISNLPNIK NYITNRKESV Y 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014187 Genomic DNA. Translation: AAN36799.1.
RefSeqXP_001348360.1. XM_001348324.1.

3D structure databases

ProteinModelPortalQ8ILQ7.
SMRQ8ILQ7. Positions 1-211.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5833.PF14_0187-1.

Chemistry

BindingDBQ8ILQ7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsPF14_0187:mRNA; PF14_0187:pep; PF14_0187.
GeneID811768.
KEGGpfa:PF14_0187.

Organism-specific databases

EuPathDBPlasmoDB:PF3D7_1419300.

Phylogenomic databases

HOGENOMHOG000115733.
KOK00799.
OMANELEPWA.
PhylomeDBQ8ILQ7.
ProtClustDBPTZ00057.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST_PLAF7
AccessionPrimary (citable) accession number: Q8ILQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families