Q8ILQ7 (GST_PLAF7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase
EC=2.5.1.18

Gene names

Name:	GST
ORF Names:	PF14_0187

Organism

Plasmodium falciparum (isolate 3D7) [Reference proteome]

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Glutathione S-transferase		PRO_0000259967
Regions
	Domain	3 – 87	85	GST N-terminal
	Domain	89 – 211	123	GST C-terminal
	Region	58 – 59	2	Glutathione binding By similarity
	Region	71 – 72	2	Glutathione binding By similarity
Sites
	Binding site	9	1	Glutathione By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8ILQ7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: EDC79583CFC9D751	FASTA	211	24,789
	10 20 30 40 50 60 MGDNIVLYYF DARGKAELIR LIFAYLGIEY TDKRFGVNGD AFVEFKNFKK EKDTPFEQVP 70 80 90 100 110 120 ILQIGDLILA QSQAIVRYLS KKYNICGESE LNEFYADMIF CGVQDIHYKF NNTNLFKQNE 130 140 150 160 170 180 TTFLNEDLPK WSGYFEKLLK KNHTNNNNDK YYFVGNNLTY ADLAVFNLYD DIETKYPSSL 190 200 210 KNFPLLKAHN EFISNLPNIK NYITNRKESV Y

References

[1]

"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014187 Genomic DNA. Translation: AAN36799.1.
RefSeq	XP_001348360.1. XM_001348324.1.
3D structure databases
HSSP	HSSP built from PDB template 1K3O based on UniProtKB P08263.
ProteinModelPortal	Q8ILQ7.
SMR	Q8ILQ7. Positions 1-211.
ModBase	Search...
Protein-protein interaction databases
STRING	5833.PF14_0187-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	PF14_0187:mRNA; PF14_0187:pep; PF14_0187.
GeneID	811768.
KEGG	pfa:PF14_0187.
Organism-specific databases
EuPathDB	PlasmoDB:PF3D7_1419300.
Phylogenomic databases
HOGENOM	HOG000115733.
KO	K00799.
OMA	NELEPWA.
ProtClustDB	PTZ00057.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q8ILQ7.

Entry information

Entry name

GST_PLAF7

Accession

Primary (citable) accession number: Q8ILQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)