Glucose-6-phosphate isomerase - Plasmodium falciparum (isolate 3D7)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase RuleBase RU000612
EC=5.3.1.9 RuleBase RU000612

Gene names

ORF Names:

PF14_0341 EMBL AAN36954.1

Organism

Plasmodium falciparum (isolate 3D7)

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	579 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. RuleBase RU000612
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. RuleBase RU000612
Subcellular location	Cytoplasm By similarity RuleBase RU003642.
Sequence similarities	Belongs to the GPI family. RuleBase RU000612

Ontologies

Keywords
Biological process	Gluconeogenesis RuleBase RU000612 Glycolysis RuleBase RU000612
Molecular function	Isomerase RuleBase RU000612 EMBL AAN36954.1
Technical term	3D-structure PDB 3PR3 PDB 3QKI Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Region

158 – 159

2

Fructose-6-phosphate binding PDB 3PR3

Region

231 – 236

6

Fructose-6-phosphate binding PDB 3PR3

Sites

Binding site

380

1

Fructose-6-phosphate PDB 3PR3

Binding site

411

1

Fructose-6-phosphate PDB 3PR3

Binding site

540

1

Fructose-6-phosphate PDB 3PR3

Sequences

Sequence

Length

Mass (Da)

Tools

Q8ILA4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 74F92B6ED4134238
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FASTA

579

67,368

        10         20         30         40         50         60 
MNMEITNLKS YKELVTLSAE EKTKDLKDYL NDKNRSESLI KKFKNFYMDL SRQRYSEKTL 

        70         80         90        100        110        120 
NKLVEYAEEV ELKKKVEKTF MGEKVNMTEN RSVLHTALRI PIEKINTHKI IIDNKNVLED 

       130        140        150        160        170        180 
VHGVLKKIEK YSDDIRNGVI KTCKNTKFKN VICIGIGGSY LGTEFVYEAM KYYYYNMELN 

       190        200        210        220        230        240 
KNEKDQVNNF NNNYDQDNVF NVRFLANVDP NDVNRAIQNL DQYDTLVIII SKTFTTAETM 

       250        260        270        280        290        300 
LNARSIKKWL SLKIKDDENL SKHMVAVSTN LKLTDEFGIS RDNVFEFWDW VGGRFSVTSS 

       310        320        330        340        350        360 
VGILPLSIAF GYKNMRNFLN GCHDMDEHFL HADLKENIPV LLALTSFYNS HFFDYKNVAI 

       370        380        390        400        410        420 
LPYFQNLLKF SAHIQQLSME SNGKSVDRNN QPIHYNTCQV YFGEPGTNGQ HSFYQLIHQG 

       430        440        450        460        470        480 
QVIPVELIGF KHSHFPIKFD KEVVSNHDEL MTNFFAQADA LAIGKTYEQV KEENEKNKMS 

       490        500        510        520        530        540 
PELLTHKVFN GNRPSTLLLF DELNFYTCGL LLSLYESRIV AEGFLLNINS FDQWGVELGK 

       550        560        570 
VLAKEVRNYF NDTRNQKKSD NTYNFNESTK ILLNYYLSK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. Barrell B.G. Nature 419:498-511(2002) [PubMed: 12368864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[2]	"Crystal structure of Glucose-6-Phosphate Isomerase (PF14_0341) from Plasmodium falciparum 3D7." Gileadi T., Wernimont A.K., Hills T., Hui R., Pizarro J.C. Submitted (FEB-2011) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS).
[3]	"Crystal structure of Plasmodium falciparum glucose-6-phosphate isomerase (PF14_0341) in complex with fructose-6-phosphate." Gileadi T., Wernimont A.K., Hills T., Hui R., Pizarro J.C. Submitted (NOV-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) IN COMPLEX WITH FRUCTOSE-6-PHOSPHATE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE014187 Genomic DNA. Translation: AAN36954.1.

RefSeq

XP_001348515.1. XM_001348479.2.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3PR3	X-ray	2.45	A/B	1-579	[»]
3QKI	X-ray	1.92	A/B/C	1-579	[»]

ProteinModelPortal

Q8ILA4.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8ILA4. 1 interaction.

MINT

MINT-1572759.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

PF14_0341:mRNA; PF14_0341:pep; PF14_0341.

GeneID

811923.

KEGG

pfa:PF14_0341.

NMPDR

fig|36329.1.peg.2217.

Organism-specific databases

EuPathDB

EupathDB:PF14_0341.

Phylogenomic databases

GeneTree

EPrGT00050000005715.

HOGENOM

HBG352954.

OMA

NSLPAWT.

ProtClustDB

PTZ00430.

Family and domain databases

HAMAP

MF_00473. G6P_isomerase.
[Tree]

InterPro

IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]

Gene3D

G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.

KO

K01810.

PANTHER

PTHR11469. G6P_Isomerase. 1 hit.

Pfam

PF00342. PGI. 1 hit.
[Graphical view]

PRINTS

PR00662. G6PISOMERASE.

PROSITE

PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8ILA4_PLAF7

Accession

Primary (citable) accession number: Q8ILA4

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)