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Protein

ATP-dependent Clp protease proteolytic subunit

Gene

PF14_0348

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: GeneDB_Pfalciparum

GO - Biological processi

  1. proteolysis Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, ProteaseImported

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease proteolytic subunitUniRule annotation
Gene namesi
ORF Names:PF14_0348Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1436800.

Subcellular locationi

GO - Cellular componenti

  1. apicoplast Source: GeneDB_Pfalciparum
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5833.PF14_0348-1.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GM2X-ray2.80A/B/C/D/E/F/G61-244[»]
4HNKX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L/M/N49-244[»]
ProteinModelPortaliQ8IL98.
SMRiQ8IL98. Positions 61-243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S14 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000285833.
InParanoidiQ8IL98.
KOiK01358.
OMAiQLMYLEH.
PhylomeDBiQ8IL98.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IL98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGLLLFMLI CINFCKCTKI ITRYNFITNK INIKRYKKKN NNKSPLYYSY
60 70 80 90 100
NEHHKYNINI PSLLLSKRII FLSSPIYPHI SEQIISQLLY LEYESKRKPI
110 120 130 140 150
HLYINSTGDI DNNKIINLNG ITDVISIVDV INYISSDVYT YCLGKAYGIA
160 170 180 190 200
CILASSGKKG YRFSLKNSSF CLNQSYSIIP FNQATNIEIQ NKEIMNTKKK
210 220 230 240
VIEIISKNTE KDTNVISNVL ERDKYFNADE AVDFKLIDHI LEKE
Length:244
Mass (Da):28,325
Last modified:March 1, 2003 - v1
Checksum:iF3BCBDB584F25DF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN36961.1.
RefSeqiXP_001348522.1. XM_001348486.1.

Genome annotation databases

EnsemblProtistsiPF14_0348:mRNA; PF14_0348:pep; PF14_0348.
GeneIDi811930.
KEGGipfa:PF14_0348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN36961.1.
RefSeqiXP_001348522.1. XM_001348486.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GM2X-ray2.80A/B/C/D/E/F/G61-244[»]
4HNKX-ray2.90A/B/C/D/E/F/G/H/I/J/K/L/M/N49-244[»]
ProteinModelPortaliQ8IL98.
SMRiQ8IL98. Positions 61-243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PF14_0348-1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPF14_0348:mRNA; PF14_0348:pep; PF14_0348.
GeneIDi811930.
KEGGipfa:PF14_0348.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1436800.

Phylogenomic databases

HOGENOMiHOG000285833.
InParanoidiQ8IL98.
KOiK01358.
OMAiQLMYLEH.
PhylomeDBiQ8IL98.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR001907. ClpP.
IPR029045. ClpP/crotonase-like_dom.
IPR023562. ClpP/TepA.
[Graphical view]
PANTHERiPTHR10381. PTHR10381. 1 hit.
PfamiPF00574. CLP_protease. 1 hit.
[Graphical view]
PRINTSiPR00127. CLPPROTEASEP.
SUPFAMiSSF52096. SSF52096. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum."
    El Bakkouri M., Rathore S., Calmettes C., Wernimont A.K., Liu K., Sinha D., Asad M., Jung P., Hui R., Mohmmed A., Houry W.A.
    J. Biol. Chem. 288:1022-1031(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 61-244.

Entry informationi

Entry nameiQ8IL98_PLAF7
AccessioniPrimary (citable) accession number: Q8IL98
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.