Q8IL68 (Q8IL68_PLAF7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	PBGS EMBL AAN36994.1
ORF Names:	PF14_0381 EMBL AAN36994.1

Organism

Plasmodium falciparum (isolate 3D7)

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Molecular function	Lyase RuleBase RU000515 EMBL AAN36994.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	apicoplast Inferred from direct assay. Source: GeneDB_Pfalciparum
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IL68 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: B9D3001C167590D3	FASTA	451	53,188
	10 20 30 40 50 60 MLKSDVVLLL YILIINLICC LNGNSKKRAY ILNTPKSSNC KRSSFRRWNN PVNNNNSQIL 70 80 90 100 110 120 SKNEGSIEDV YNKKISGRCN IKNFSKDINN NIYIETNRRE RRIKRNKYLL SLYNNTNIKT 130 140 150 160 170 180 SNFIYPLFIH EEDVEKKHTQ LEGIYTYNVD GIIKEIEECI KLNIHHFMFF PVIREENKTV 190 200 210 220 230 240 YCEESYNENS YFCKTISRIK EKFSDDIIVY TDVALDPYNI YGHDGIYDDN KKEILNDITV 250 260 270 280 290 300 HTLVKQSLCL AKSGADVVCP SDSMDKRIEL IRKNLDFHNF RDILILSYTC KYSSSMYKPF 310 320 330 340 350 360 RSILNSNILK NFVKNKQSYQ HDFNSYMDLN NVDKHIIEGA DIIMVKPSMF YLDIIHKIKN 370 380 390 400 410 420 RIKDDVQIPI AVYNVSGEYM MIKNYVKYLN EDINYENEII TELFKSYLRA GANIIITYFA 430 440 450 KQYGLYMKKL YDKNIIIDDN SNNNFNIELT L

References

[1]

"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed: 12368864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014187 Genomic DNA. Translation: AAN36994.1.
RefSeq	XP_001348555.1. XM_001348519.1.
3D structure databases
HSSP	HSSP built from PDB template 1GZG based on UniProtKB Q59643.
ProteinModelPortal	Q8IL68.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	PF14_0381:mRNA; PF14_0381:pep; PF14_0381.
GeneID	811963.
GenomeReviews	Gene locus PBGS in contig AE014187_GR.
KEGG	pfa:PF14_0381.
NMPDR	fig|36329.1.peg.2257.
Organism-specific databases
EuPathDB	EupathDB:PF14_0381.
Phylogenomic databases
GeneTree	EPrGT00050000005791.
HOGENOM	HBG285270.
OMA	CEDESEG.
ProtClustDB	CLSZ2432714.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8IL68_PLAF7

Accession

Primary (citable) accession number: Q8IL68

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)