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Protein

Heme ligase

Gene

HDP

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Heme detoxifying enzyme that converts heme to crystalline hemozoin (beta-hematin) to protect the organism from the toxic effects of heme. During its development, P.falciparum proteolyzes vast amounts of host hemoglobin, leading to heme release.1 Publication

Catalytic activityi

2 ferriprotoporphyrin IX = beta-hematin.1 Publication

pH dependencei

Optimum pH is 4.5-5.2.1 Publication

GO - Molecular functioni

  • heme binding Source: GeneDB
  • heme oxygenase (decyclizing) activity Source: GeneDB
  • lyase activity Source: UniProtKB

GO - Biological processi

  • heme catabolic process Source: UniProtKB
  • metabolic process Source: UniProtKB
  • pathogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15023.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme ligase (EC:4.99.1.8)
Alternative name(s):
Heme detoxification protein
Short name:
HDP
Hemozoin synthase
Gene namesi
Name:HDP
ORF Names:PF14_0446
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1446800.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • food vacuole Source: GeneDB
  • host cell cytoplasm Source: GeneDB
  • host cell cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Heme ligasePRO_0000418492Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8IL04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 203156FAS1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 FAS1 domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000282097.
InParanoidiQ8IL04.
KOiK17949.
PhylomeDBiQ8IL04.

Family and domain databases

Gene3Di2.30.180.10. 1 hit.
InterProiIPR000782. FAS1_domain.
[Graphical view]
PfamiPF02469. Fasciclin. 1 hit.
[Graphical view]
SMARTiSM00554. FAS1. 1 hit.
[Graphical view]
SUPFAMiSSF82153. SSF82153. 1 hit.
PROSITEiPS50213. FAS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IL04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNRFYYNLI IKRLYTRSGG LRKPQKVTND PESINRKVYW CFEHKPVKRT
60 70 80 90 100
IINLIYSHNE LKIFSNLLNH PTVGSSLIHE LSLDGPYTAF FPSNEAMQLI
110 120 130 140 150
NIESFNKLYN DENKLSEFVL NHVTKEYWLY RDLYGSSYQP WLMYNEKREA
160 170 180 190 200
PEKLRNLLNN DLIVKIEGEF KHCNHSIYLN GSKIIRPNMK CHNGVVHIVD

KPIIF
Length:205
Mass (Da):24,337
Last modified:March 1, 2003 - v1
Checksum:iC4DDCB978236C3CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN37059.1.
RefSeqiXP_001348620.1. XM_001348584.1.

Genome annotation databases

EnsemblProtistsiPF14_0446:mRNA; PF14_0446:pep; PF14_0446.
GeneDBiPF3D7_1446800.1:pep.
GeneIDi812028.
KEGGipfa:PF14_0446.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN37059.1.
RefSeqiXP_001348620.1. XM_001348584.1.

3D structure databases

ProteinModelPortaliQ8IL04.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPF14_0446:mRNA; PF14_0446:pep; PF14_0446.
GeneDBiPF3D7_1446800.1:pep.
GeneIDi812028.
KEGGipfa:PF14_0446.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1446800.

Phylogenomic databases

HOGENOMiHOG000282097.
InParanoidiQ8IL04.
KOiK17949.
PhylomeDBiQ8IL04.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15023.

Family and domain databases

Gene3Di2.30.180.10. 1 hit.
InterProiIPR000782. FAS1_domain.
[Graphical view]
PfamiPF02469. Fasciclin. 1 hit.
[Graphical view]
SMARTiSM00554. FAS1. 1 hit.
[Graphical view]
SUPFAMiSSF82153. SSF82153. 1 hit.
PROSITEiPS50213. FAS1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHDP_PLAF7
AccessioniPrimary (citable) accession number: Q8IL04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: March 1, 2003
Last modified: July 6, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

HDP is critical for survival, suggesting it could be a potential malaria drug target.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.