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Protein
Submitted name:

DNA polymerase alpha subunit B, putative

Gene

PF14_0602

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • DNA binding Source: InterPro
  • DNA-directed DNA polymerase activity Source: GeneDB
  • protein heterodimerization activity Source: GO_Central

GO - Biological processi

  • DNA replication, synthesis of RNA primer Source: GeneDB
  • DNA replication initiation Source: GO_Central

Enzyme and pathway databases

ReactomeiR-PFA-113501. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
R-PFA-174411. Polymerase switching on the C-strand of the telomere.
R-PFA-174430. Telomere C-strand synthesis initiation.
R-PFA-68952. DNA replication initiation.
R-PFA-68962. Activation of the pre-replicative complex.
R-PFA-69091. Polymerase switching.
R-PFA-69166. Removal of the Flap Intermediate.
R-PFA-69183. Processive synthesis on the lagging strand.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA polymerase alpha subunit B, putativeImported
Submitted name:
DNA polymerase alpha subunit, putativeImported
Gene namesi
ORF Names:PF14_0602Imported, PF3D7_1463300Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1463300.

Subcellular locationi

GO - Cellular componenti

  • alpha DNA polymerase:primase complex Source: GeneDB

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini276 – 475DNA_pol_E_BInterPro annotationAdd BLAST200

Phylogenomic databases

HOGENOMiHOG000281942.
InParanoidiQ8IKK3.
KOiK02321.
OMAiSYIYINE.

Family and domain databases

InterProiView protein in InterPro
IPR007185. DNA_pol_alpha/epsilon_bsu.
IPR016722. DNA_pol_alpha_bsu.
PANTHERiPTHR23061. PTHR23061. 2 hits.
PfamiView protein in Pfam
PF04042. DNA_pol_E_B. 1 hit.
PIRSFiPIRSF018300. DNA_pol_alph_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8IKK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIKQADVK HYLETYYTDN SIGDDLKEAF DYIERNKHKN NFHKLFEDYL
60 70 80 90 100
EDYNKKLLKN GTLLRDHVVY EYERVKQYNS ELIETEGRSC NNKYHYYINY
110 120 130 140 150
VNSINENYKF LGLDTNVICD CINKKISLFL ELFLKYSKKL NLNIEIEPIL
160 170 180 190 200
NMSDDESYIF GRIYTENEMN ISESNIILEG NMKWNNGDKA QLLNLTDMRN
210 220 230 240 250
ICFFLGQILA IKGKKEINQF SIKYYVSNVY AGLPSHLKVQ IDKEFVLKHF
260 270 280 290 300
NTKEIEEDSK IHENILHLYN NENIHIMICN GYIYNDNNYS ENLDNFLKVV
310 320 330 340 350
NEKLPHVVLI FGPFLYIRNF SETIQKIGDI NIIYENLFKK ITKFAKNEIL
360 370 380 390 400
EKTHFFIIPS IYDSINIYPL PQPPFYYENS NINSPNVHFL SNPSYIYINE
410 420 430 440 450
LKIALTSCDI VYNLTRNLLC RPSELKLFYL FEQILRQLSL FPSYPSEYNI
460 470 480 490 500
EITKFKNLLF QPNRLPDIFI YPSFTNEKSY IKEVHKKLFI CPYSIDVNKA
510 520 530
QPSKFFSNIY ILPPNETNEL SKRVILENIF ISNNKTNNI
Length:539
Mass (Da):64,036
Last modified:March 1, 2003 - v1
Checksum:i9858F3A28B08DEBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN37215.1.
LN999946 Genomic DNA. Translation: CZU00330.1.
RefSeqiXP_001348776.1. XM_001348740.1.

Genome annotation databases

EnsemblProtistsiCZU00330; CZU00330; PF3D7_1463300.
GeneDBiPF3D7_1463300.1:pep.
GeneIDi812184.
KEGGipfa:PF14_0602.

Similar proteinsi

Entry informationi

Entry nameiQ8IKK3_PLAF7
AccessioniPrimary (citable) accession number: Q8IKK3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported