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Protein
Submitted name:

Eukaryotic initiation factor 4A

Gene

H45

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • 3'-5' DNA/RNA helicase activity Source: GeneDB
  • ATPase activity Source: GeneDB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent helicase activity Source: GeneDB
  • ATP-dependent RNA helicase activity Source: GO_Central
  • mRNA binding Source: GeneDB
  • RNA cap binding Source: GeneDB
  • translation initiation factor activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotationImported, Hydrolase, Initiation factorImported
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-PFA-72702. Ribosomal scanning and start codon recognition.

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic initiation factor 4AImported (EC:3.6.4.12Imported)
Submitted name:
Helicase 45Imported
Gene namesi
Name:H45Imported
ORF Names:PF14_0655Imported, PF3D7_1468700Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1468700.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GeneDB
  • eukaryotic translation initiation factor 4F complex Source: GeneDB
  • nucleolus Source: GO_Central

Interactioni

Protein-protein interaction databases

IntActiQ8IKF0. 1 interactor.
MINTiMINT-1575859.

Structurei

3D structure databases

SMRiQ8IKF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 51Q_MOTIFInterPro annotationAdd BLAST29
Domaini54 – 224Helicase ATP-bindingInterPro annotationAdd BLAST171
Domaini235 – 398Helicase C-terminalInterPro annotationAdd BLAST164

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi23 – 51Q motifPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000268797.
InParanoidiQ8IKF0.
KOiK03257.
OMAiFGCQALV.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IKF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKEETFNN ENDIEGNTEE IVDTFDALGL NEKLLRGIYS YGFEKPSAIQ
60 70 80 90 100
QRGIKPILNG YDTIGQAQSG TGKTATFVIS SLQLINYDYV ACQALILAPT
110 120 130 140 150
RELAQQIQKV VLALGDYLKV KCHACVGGTV VREDIDKLKQ GVHMVVGTPG
160 170 180 190 200
RVYDMIDKRH LGVDRLKLFI LDEADEMLSR GFKAQIYEVF KKLVPDIQVA
210 220 230 240 250
LFSATMPQEI LELTTRFMRD PKTILVKKDE LTLEGIRQFY VAVEKEEWKL
260 270 280 290 300
DTLCDLYETL TITQSIIYCN TRKKVDILTQ EMHNRLFTVS CMHGDMDQKD
310 320 330 340 350
RDLIMREFRS GSTRVLVTTD LLARGIDVQQ VSLVINYDLP ASPDTYIHRI
360 370 380 390
GRSGRFGRKG VAINFVTNDD KEKDKLKKIE SYYSTQIEEM PLEVADYL
Length:398
Mass (Da):45,310
Last modified:March 1, 2003 - v1
Checksum:i701B73A48C5F3476
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN37268.1.
LN999946 Genomic DNA. Translation: CZU00384.1.
RefSeqiXP_001348829.1. XM_001348793.1.

Genome annotation databases

EnsemblProtistsiCZU00384; CZU00384; PF3D7_1468700.
GeneDBiPF3D7_1468700.1:pep.
GeneIDi812237.
KEGGipfa:PF14_0655.

Similar proteinsi

Entry informationi

Entry nameiQ8IKF0_PLAF7
AccessioniPrimary (citable) accession number: Q8IKF0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported