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Protein
Submitted name:

Eukaryotic initiation factor 4A

Gene

PF3D7_1468700

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • 3'-5' DNA/RNA helicase activity Source: GeneDB
  • ATPase activity Source: GeneDB
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent helicase activity Source: GeneDB
  • ATP-dependent RNA helicase activity Source: GO_Central
  • mRNA binding Source: GeneDB
  • RNA cap binding Source: GeneDB
  • translation initiation factor activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase, Initiation factorImported
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-PFA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-PFA-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic initiation factor 4AImported (EC:3.6.4.12Imported)
Gene namesi
ORF Names:PF3D7_1468700Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1468700

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GeneDB
  • eukaryotic translation initiation factor 4F complex Source: GeneDB
  • nucleolus Source: GO_Central

Pathology & Biotechi

Chemistry databases

DrugBankiDB11638 Artenimol

Interactioni

Protein-protein interaction databases

IntActiQ8IKF0, 1 interactor

Structurei

3D structure databases

SMRiQ8IKF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

KOiK03257
OMAiRNPIRIL

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IKF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTKEETFNN ENDIEGNTEE IVDTFDALGL NEKLLRGIYS YGFEKPSAIQ
60 70 80 90 100
QRGIKPILNG YDTIGQAQSG TGKTATFVIS SLQLINYDYV ACQALILAPT
110 120 130 140 150
RELAQQIQKV VLALGDYLKV KCHACVGGTV VREDIDKLKQ GVHMVVGTPG
160 170 180 190 200
RVYDMIDKRH LGVDRLKLFI LDEADEMLSR GFKAQIYEVF KKLVPDIQVA
210 220 230 240 250
LFSATMPQEI LELTTRFMRD PKTILVKKDE LTLEGIRQFY VAVEKEEWKL
260 270 280 290 300
DTLCDLYETL TITQSIIYCN TRKKVDILTQ EMHNRLFTVS CMHGDMDQKD
310 320 330 340 350
RDLIMREFRS GSTRVLVTTD LLARGIDVQQ VSLVINYDLP ASPDTYIHRI
360 370 380 390
GRSGRFGRKG VAINFVTNDD KEKDKLKKIE SYYSTQIEEM PLEVADYL
Length:398
Mass (Da):45,310
Last modified:March 1, 2003 - v1
Checksum:i701B73A48C5F3476
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999946 Genomic DNA Translation: CZU00384.1
RefSeqiXP_001348829.1, XM_001348793.1

Genome annotation databases

EnsemblProtistsiCZU00384; CZU00384; PF3D7_1468700
GeneDBiPF3D7_1468700.1:pep
GeneIDi812237
KEGGipfa:PF14_0655

Similar proteinsi

Entry informationi

Entry nameiQ8IKF0_PLAF7
AccessioniPrimary (citable) accession number: Q8IKF0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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