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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

PF3D7_1034400

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PF3D7_1034400), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (PF3D7_1212800)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: GO_Central
  • tricarboxylic acid cycle Source: GeneDB

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:PF3D7_1034400Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1034400

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) Source: GeneDB
  • mitochondrion Source: GeneDB

Keywords - Cellular componenti

MembraneUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

KOiK00234
OMAiGDSPWEH

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IJ66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRNNKKYIR FMQSSFCRFS NIKTKAYDII DHHYDAVIVG AGGAGLRSAL
60 70 80 90 100
ELSKNKYKVA CISKLFPTRS HTVAAQGGIN AALGNMTEDD WRWHAYDTIK
110 120 130 140 150
GSDWLGDQNA IHYMCREAPD SVLELEEFGL PFSRTKDGKI YQRAFGGQSL
160 170 180 190 200
KYGKGGQAYR CAAAADRTGH AMLHTLYGQS LSYNCIFFVE YFVLDLLMLN
210 220 230 240 250
SNECIGVICI NIADGKIHRF FTPHTVIATG GYGRAYLSCT SAHACTGDGN
260 270 280 290 300
AIVARSKLPL QDLEFVQFHP TGIYPAGCLI TEGCRGEGGI LRNKEGEAFM
310 320 330 340 350
MRYAPKAKDL ASRDVVSRAM TIEINEQRGC GPNADHIYLD LTHLPYETLK
360 370 380 390 400
ERLPGIMETA KIFAGVDVTK QYIPVLPTVH YNMGGIPTNY KTQVLTQNVN
410 420 430 440 450
FNKQTNKSNE DIIVKGLYAA GEAASASVHG ANRLGANSLL DIVVFGKRAA
460 470 480 490 500
LTIMEIDKPN IPKINANTNI GEESIQRLDH IRFNKGSIQT SQLRKKMQIC
510 520 530 540 550
MQKHAAVFRI GPLLQEGYKQ ILEICSIFKD IEITDKTLTW NTDLLETLEL
560 570 580 590 600
ENLLTLASQT ILAAVERKES RGAHARDDFP ERDDKNYLKH SLTWMTDRNI
610 620 630
ENTKYFTTYR DVITKPLDNE MEYVPPVKRV Y
Length:631
Mass (Da):70,695
Last modified:March 1, 2003 - v1
Checksum:i33F047D64D34DB24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999944 Genomic DNA Translation: CZT98601.1
RefSeqiXP_001347618.1, XM_001347582.1

Genome annotation databases

EnsemblProtistsiCZT98601; CZT98601; PF3D7_1034400
GeneDBiPF3D7_1034400.1:pep
GeneIDi810491
KEGGipfa:PF10_0334

Similar proteinsi

Entry informationi

Entry nameiQ8IJ66_PLAF7
AccessioniPrimary (citable) accession number: Q8IJ66
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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