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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

PF10_0334

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PF10_0334), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (PFL0630w)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • succinate dehydrogenase (ubiquinone) activity Source: GeneDB

GO - Biological processi

  • electron transport chain Source: InterPro
  • tricarboxylic acid cycle Source: GeneDB
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:PF10_0334Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1034400.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

  • mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) Source: GeneDB
  • mitochondrion Source: GeneDB
Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8IJ66.

Interactioni

Protein-protein interaction databases

STRINGi5833.PF10_0334.

Structurei

3D structure databases

ProteinModelPortaliQ8IJ66.
SMRiQ8IJ66. Positions 27-631.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

HOGENOMiHOG000160475.
InParanoidiQ8IJ66.
KOiK00234.
OMAiLTNDVQY.
PhylomeDBiQ8IJ66.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IJ66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRNNKKYIR FMQSSFCRFS NIKTKAYDII DHHYDAVIVG AGGAGLRSAL
60 70 80 90 100
ELSKNKYKVA CISKLFPTRS HTVAAQGGIN AALGNMTEDD WRWHAYDTIK
110 120 130 140 150
GSDWLGDQNA IHYMCREAPD SVLELEEFGL PFSRTKDGKI YQRAFGGQSL
160 170 180 190 200
KYGKGGQAYR CAAAADRTGH AMLHTLYGQS LSYNCIFFVE YFVLDLLMLN
210 220 230 240 250
SNECIGVICI NIADGKIHRF FTPHTVIATG GYGRAYLSCT SAHACTGDGN
260 270 280 290 300
AIVARSKLPL QDLEFVQFHP TGIYPAGCLI TEGCRGEGGI LRNKEGEAFM
310 320 330 340 350
MRYAPKAKDL ASRDVVSRAM TIEINEQRGC GPNADHIYLD LTHLPYETLK
360 370 380 390 400
ERLPGIMETA KIFAGVDVTK QYIPVLPTVH YNMGGIPTNY KTQVLTQNVN
410 420 430 440 450
FNKQTNKSNE DIIVKGLYAA GEAASASVHG ANRLGANSLL DIVVFGKRAA
460 470 480 490 500
LTIMEIDKPN IPKINANTNI GEESIQRLDH IRFNKGSIQT SQLRKKMQIC
510 520 530 540 550
MQKHAAVFRI GPLLQEGYKQ ILEICSIFKD IEITDKTLTW NTDLLETLEL
560 570 580 590 600
ENLLTLASQT ILAAVERKES RGAHARDDFP ERDDKNYLKH SLTWMTDRNI
610 620 630
ENTKYFTTYR DVITKPLDNE MEYVPPVKRV Y
Length:631
Mass (Da):70,695
Last modified:March 1, 2003 - v1
Checksum:i33F047D64D34DB24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014834 Genomic DNA. Translation: AAN35531.1.
RefSeqiXP_001347618.1. XM_001347582.1.

Genome annotation databases

EnsemblProtistsiPF10_0334:mRNA; PF10_0334:pep; PF10_0334.
GeneIDi810491.
KEGGipfa:PF10_0334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014834 Genomic DNA. Translation: AAN35531.1.
RefSeqiXP_001347618.1. XM_001347582.1.

3D structure databases

ProteinModelPortaliQ8IJ66.
SMRiQ8IJ66. Positions 27-631.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PF10_0334.

Proteomic databases

PRIDEiQ8IJ66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPF10_0334:mRNA; PF10_0334:pep; PF10_0334.
GeneIDi810491.
KEGGipfa:PF10_0334.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1034400.

Phylogenomic databases

HOGENOMiHOG000160475.
InParanoidiQ8IJ66.
KOiK00234.
OMAiLTNDVQY.
PhylomeDBiQ8IJ66.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.

Entry informationi

Entry nameiQ8IJ66_PLAF7
AccessioniPrimary (citable) accession number: Q8IJ66
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.