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Protein

DNA repair protein RAD51 homolog

Gene

Rad51

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: GeneDB
  • damaged DNA binding Source: GeneDB
  • DNA binding Source: GeneDB
  • DNA-dependent ATPase activity Source: GeneDB
  • double-stranded DNA binding Source: GO_Central
  • four-way junction DNA binding Source: GO_Central
  • recombinase activity Source: GeneDB
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD51 homologUniRule annotation
Gene namesi
Name:Rad51Imported
ORF Names:PF11_0087Imported, PF3D7_1107400Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1107400.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

  • condensed nuclear chromosome Source: GO_Central
  • nucleoplasm Source: GO_Central
  • nucleus Source: GeneDB

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

PTM databases

SwissPalmiQ8IIS8.

Structurei

3D structure databases

SMRiQ8IIS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 279RECA_2InterPro annotationAdd BLAST172
Domaini286 – 349RECA_3InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the RecA family. RAD51 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227426.
InParanoidiQ8IIS8.
KOiK04482.
OMAiVGHTATF.

Family and domain databases

CDDicd01123. Rad51_DMC1_radA. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011941. DNA_recomb/repair_Rad51.
IPR013632. DNA_recomb/repair_Rad51_C.
IPR016467. DNA_recomb/repair_RecA-like.
IPR010995. DNA_repair_Rad51/TF_NusA_a-hlx.
IPR027417. P-loop_NTPase.
IPR033925. Rad51_DMC1_RadA.
IPR020588. RecA_ATP-bd.
IPR020587. RecA_monomer-monomer_interface.
PfamiView protein in Pfam
PF08423. Rad51. 1 hit.
PIRSFiPIRSF005856. Rad51. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF47794. SSF47794. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02239. recomb_RAD51. 1 hit.
PROSITEiView protein in PROSITE
PS50162. RECA_2. 1 hit.
PS50163. RECA_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IIS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQANTKEDK SQKISNSSTI DEIEEEQLYT GPLKIEQLLA KGFVKRDLEL
60 70 80 90 100
LKEGGLQTVE CVAYAPMRTL CAIKGISEQK AEKLKKACKE LCNSGFCNAI
110 120 130 140 150
DYHDARQNLI KFTTGSKQLD ALLKGGIETG GITELFGEFR TGKSQLCHTL
160 170 180 190 200
AITCQLPIEQ SGGEGKCLWI DTEGTFRPER IVAIAKRYGL HPTDCLNNIA
210 220 230 240 250
YAKAYNCDHQ TELLIDASAM MADARFALLI VDSATALYRS EYIGRGELAN
260 270 280 290 300
RQSHLCRFLR GLQRIADIYG VAVIITNQVV AKVDAMSMFG GHEKIPIGGN
310 320 330 340 350
IIAHASQTRL YLRKGRGESR ICKIYDSPVL PEGEAVFAIT EGGIADYEEK
Length:350
Mass (Da):38,592
Last modified:September 22, 2009 - v2
Checksum:i5BA0988628B164CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014186 Genomic DNA. Translation: AAN35675.2.
LN999945 Genomic DNA. Translation: CZT98740.1.
RefSeqiXP_001347762.2. XM_001347726.2.

Genome annotation databases

EnsemblProtistsiCZT98740; CZT98740; PF3D7_1107400.
GeneDBiPF3D7_1107400.1:pep.
GeneIDi810638.
KEGGipfa:PF11_0087.

Similar proteinsi

Entry informationi

Entry nameiQ8IIS8_PLAF7
AccessioniPrimary (citable) accession number: Q8IIS8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: September 22, 2009
Last modified: December 20, 2017
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported