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Protein
Submitted name:

DNA mismatch repair protein MLH

Gene

PF11_0184

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  • ATPase activity Source: GeneDB
  • ATP binding Source: GeneDB
  • endonuclease activity Source: GeneDB
  • mismatched DNA binding Source: InterPro
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

  • mismatch repair Source: GeneDB

Enzyme and pathway databases

ReactomeiR-PFA-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Names & Taxonomyi

Protein namesi
Submitted name:
DNA mismatch repair protein MLHImported
Submitted name:
DNA mismatch repair protein MLH1, putativeImported
Gene namesi
ORF Names:PF11_0184Imported, PF3D7_1117800Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1117800.

Subcellular locationi

GO - Cellular componenti

Structurei

3D structure databases

SMRiQ8IIJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini410 – 531DNA_mis_repairInterPro annotationAdd BLAST122

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili915 – 935Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000282300.
InParanoidiQ8IIJ0.
KOiK08734.
OMAiHDNNITC.

Family and domain databases

CDDicd00075. HATPase_c. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiView protein in InterPro
IPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR011186. DNA_mismatch_repair_MLH1.
IPR003594. HATPase_C.
IPR036890. HATPase_C_sf.
IPR032189. Mlh1_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PANTHERiPTHR10073:SF40. PTHR10073:SF40. 1 hit.
PfamiView protein in Pfam
PF01119. DNA_mis_repair. 1 hit.
PF16413. Mlh1_C. 1 hit.
SMARTiView protein in SMART
SM01340. DNA_mis_repair. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiView protein in PROSITE
PS00058. DNA_MISMATCH_REPAIR_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IIJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINEDINICG NINMKDNDRD NDNNDKYNDK YNNNNNDNIL MNDSNGDRRI
60 70 80 90 100
IKLAEEDINR IAAGEVIIRP CNALKELVEN SLDANSSSIS IHLNKGGLKS
110 120 130 140 150
LQIIDDGDGI HKEDLRIVCE RFTTSKISNH KDIRNIKTFG FRGEALASIS
160 170 180 190 200
HVSYLTITSK KRNSPFCYTC NYKDGKPTQD EPTVCSGKNG TIIRFDDLFY
210 220 230 240 250
NMPARLKTMN PNDEYNKCLE VLQKYAIHYP NVSFTCKKWL SNTVDLNTQK
260 270 280 290 300
VGKGIGGYAG IYIIKKKRKE RFDENNTTDG NLPCDNNMTC NNLPHDNNIT
310 320 330 340 350
CNNLPHDNNI TCNNIPHDNN ITCNNLPHDN NITCNNLQHD NNITCNNLPH
360 370 380 390 400
DNNITCNNLP CDNNHTDKEA TDNPDASSCM YNELEKKILE EEKYLDENYE
410 420 430 440 450
KHLNNVRCVI QKVYGRNISK ELSTIFLKEK SIPTFFKCYG LISNPTYNGK
460 470 480 490 500
KGCYIFFIND RLVESNIIKK SCENQYSNFL AKGNYPWIYL SLRLKYDIVD
510 520 530 540 550
INVHPTKKEV HFLYQEEISM LIGKKIQEFL KSFHNMRTFN ITGEKLLQTK
560 570 580 590 600
LDINSSMLEI KKEDKELSKL RQGLLHDNNN VIKRQIDTKR VRTDFKQITL
610 620 630 640 650
TNYFVKKENM IDDHLDNNKS VDMLYNGDHN GDAKQIDLYE HNDEYNKTYD
660 670 680 690 700
QTNIRANLHM NYNNNNNKIE EKEYEILKLK GPNSVLYNTQ IDKHISNKIY
710 720 730 740 750
DRKYPCEADE ISSIKKLKMI CEEKEKKELT ECLKNSIYVG PVDNMHSLIQ
760 770 780 790 800
YKEKLLLIKM PLIIKEVTYQ SILNRLGKIP PFEFDPPIPL YDLLLVAVNN
810 820 830 840 850
SYSGFYENPN YANKNIEKVC NELEQIFYTY NEMYSDYFSI IIEDGCIVTF
860 870 880 890 900
PACCGEYFPG QEFLPFLFLR LATQIDYSKE INCINGICYL LANFYSKITL
910 920 930 940 950
LNDKEWTYQD DLLMIQEKEK EIQMLLNKSN KHINNSNHHN QHYDETNLDY
960 970 980 990 1000
ILGDESVVDI NKHLSVSRNI NLVFEKYFFP MIQLNNIMKI PTTFSNNGYI
1010
IELTSLNQLY KIFERC
Length:1,016
Mass (Da):118,307
Last modified:March 1, 2003 - v1
Checksum:i3B227F626D96CD03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014838 Genomic DNA. Translation: AAN35768.1.
LN999945 Genomic DNA. Translation: CZT98840.1.
RefSeqiXP_001347855.1. XM_001347819.1.

Genome annotation databases

EnsemblProtistsiCZT98840; CZT98840; PF3D7_1117800.
GeneDBiPF3D7_1117800.1:pep.
GeneIDi810731.
KEGGipfa:PF11_0184.

Similar proteinsi

Entry informationi

Entry nameiQ8IIJ0_PLAF7
AccessioniPrimary (citable) accession number: Q8IIJ0
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported