Q8II92 (Q8II92_PLAF7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative EMBL AAN35866.1

Gene names

ORF Names:

PF11_0282 EMBL AAN35866.1

Organism

Plasmodium falciparum (isolate 3D7)

Taxonomic identifier

36329 [NCBI]

Taxonomic lineage

Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Hydrolase EMBL AAN35866.1
Technical term	3D-structure PDB 1VYQ Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	dUTP diphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8II92 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 477D8A513AB0ACBF	FASTA	173	19,573
	10 20 30 40 50 60 MHLKIVCLSD EVREMYKNHK THHEGDSGLD LFIVKDEVLK PKSTTFVKLG IKAIALQYKS 70 80 90 100 110 120 NYYYKCEKSE NKKKDDDKSN IVNTSFLLFP RSSISKTPLR LANSIGLIDA GYRGEIIAAL 130 140 150 160 170 DNTSDQEYHI KKNDKLVQLV SFTGEPLSFE LVEELDETSR GEGGFGSTSN NKY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the human malaria parasite Plasmodium falciparum." Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G. Nature 419:498-511(2002) [PubMed: 12368864] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Isolate 3D7.
[2]	"dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors." Whittingham J.L., Leal I., Nguyen C., Kasinathan G., Bell E., Jones A.F., Berry C., Benito A., Turkenburg J.P., Dodson E.J., Ruiz Perez L.M., Wilkinson A.J., Johansson N.G., Brun R., Gilbert I.H., Gonzalez Pacanowska D., Wilson K.S. Structure 13:329-338(2005) [PubMed: 15698576] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE014186 Genomic DNA. Translation: AAN35866.1.

RefSeq

XP_001347953.1. XM_001347917.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VYQ	X-ray	2.40	A/B/C	1-173	[»]

ProteinModelPortal

Q8II92.

SMR

Q8II92. Positions 1-154.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-48435N.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

PF11_0282:mRNA; PF11_0282:pep; PF11_0282.

GeneID

810829.

KEGG

pfa:PF11_0282.

NMPDR

fig|36329.1.peg.1129.

Organism-specific databases

EuPathDB

EupathDB:PF11_0282.

Phylogenomic databases

GeneTree

EPrGT00060000010110.

HOGENOM

HBG436079.

OMA

CEKSENK.

ProtClustDB

PTZ00143.

Family and domain databases

InterPro

IPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]

KO

K01520.

PANTHER

PTHR11241. PTHR11241. 1 hit.

Pfam

PF00692. dUTPase. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8II92_PLAF7

Accession

Primary (citable) accession number: Q8II92

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)