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Protein
Submitted name:

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

PF3D7_1127100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • dUTP diphosphatase activity Source: GeneDB
  • identical protein binding Source: IntAct
  • magnesium ion binding Source: GO_Central

GO - Biological processi

  • DNA replication Source: GeneDB
  • dUMP biosynthetic process Source: GO_Central
  • dUTP catabolic process Source: GO_Central
  • tRNA metabolic process Source: GeneDB

Keywordsi

Molecular functionHydrolaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseImported (EC:3.6.1.23Imported)
Gene namesi
ORF Names:PF3D7_1127100Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1127100

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4222
DrugBankiDB04685 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15551503,EBI-15551503

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-48435N

Chemistry databases

BindingDBiQ8II92

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VYQX-ray2.40A/B/C1-173[»]
2Y8CX-ray2.10A/B/C1-173[»]
3T60X-ray2.40A/B/C1-173[»]
3T64X-ray1.65A/B/C1-173[»]
3T6YX-ray2.60A/B/C1-173[»]
3T70X-ray1.80A/B/C1-173[»]
SMRiQ8II92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK01520
OMAiHKTHHEG

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit

Sequencei

Sequence statusi: Complete.

Q8II92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLKIVCLSD EVREMYKNHK THHEGDSGLD LFIVKDEVLK PKSTTFVKLG
60 70 80 90 100
IKAIALQYKS NYYYKCEKSE NKKKDDDKSN IVNTSFLLFP RSSISKTPLR
110 120 130 140 150
LANSIGLIDA GYRGEIIAAL DNTSDQEYHI KKNDKLVQLV SFTGEPLSFE
160 170
LVEELDETSR GEGGFGSTSN NKY
Length:173
Mass (Da):19,573
Last modified:March 1, 2003 - v1
Checksum:i477D8A513AB0ACBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98933.1
RefSeqiXP_001347953.1, XM_001347917.1

Genome annotation databases

EnsemblProtistsiCZT98933; CZT98933; PF3D7_1127100
GeneDBiPF3D7_1127100.1:pep
GeneIDi810829
KEGGipfa:PF11_0282

Similar proteinsi

Entry informationi

Entry nameiQ8II92_PLAF7
AccessioniPrimary (citable) accession number: Q8II92
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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