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Protein
Submitted name:

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

PF11_0282

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • dUTP diphosphatase activity Source: GeneDB
  • identical protein binding Source: IntAct
  • magnesium ion binding Source: GO_Central

GO - Biological processi

  • DNA replication Source: GeneDB
  • dUMP biosynthetic process Source: GO_Central
  • dUTP catabolic process Source: GO_Central
  • tRNA metabolic process Source: GeneDB

Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

BRENDAi3.6.1.23. 4889.

Names & Taxonomyi

Protein namesi
Submitted name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseImported (EC:3.6.1.23Imported)
Submitted name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, putativeImported
Gene namesi
ORF Names:PF11_0282Imported, PF3D7_1127100Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1127100.

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4222.
DrugBankiDB04685. 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15551503,EBI-15551503

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-48435N.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VYQX-ray2.40A/B/C1-173[»]
2Y8CX-ray2.10A/B/C1-173[»]
3T60X-ray2.40A/B/C1-173[»]
3T64X-ray1.65A/B/C1-173[»]
3T6YX-ray2.60A/B/C1-173[»]
3T70X-ray1.80A/B/C1-173[»]
SMRiQ8II92.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8II92.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini87 – 168dUTPaseInterPro annotationAdd BLAST82

Phylogenomic databases

HOGENOMiHOG000028966.
InParanoidiQ8II92.
KOiK01520.
OMAiLIMPRSS.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
InterProiView protein in InterPro
IPR029054. dUTPase-like.
IPR036157. dUTPase-like_sf.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8II92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLKIVCLSD EVREMYKNHK THHEGDSGLD LFIVKDEVLK PKSTTFVKLG
60 70 80 90 100
IKAIALQYKS NYYYKCEKSE NKKKDDDKSN IVNTSFLLFP RSSISKTPLR
110 120 130 140 150
LANSIGLIDA GYRGEIIAAL DNTSDQEYHI KKNDKLVQLV SFTGEPLSFE
160 170
LVEELDETSR GEGGFGSTSN NKY
Length:173
Mass (Da):19,573
Last modified:March 1, 2003 - v1
Checksum:i477D8A513AB0ACBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014840 Genomic DNA. Translation: AAN35866.1.
LN999945 Genomic DNA. Translation: CZT98933.1.
RefSeqiXP_001347953.1. XM_001347917.1.

Genome annotation databases

EnsemblProtistsiCZT98933; CZT98933; PF3D7_1127100.
GeneDBiPF3D7_1127100.1:pep.
GeneIDi810829.
KEGGipfa:PF11_0282.

Similar proteinsi

Entry informationi

Entry nameiQ8II92_PLAF7
AccessioniPrimary (citable) accession number: Q8II92
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 22, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported