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Protein
Submitted name:

Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative

Gene

PF11_0282

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: GeneDB
  • dUMP biosynthetic process Source: GO_Central
  • dUTP catabolic process Source: GO_Central
  • tRNA metabolic process Source: GeneDB
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Enzyme and pathway databases

BRENDAi3.6.1.23. 4889.

Names & Taxonomyi

Protein namesi
Submitted name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, putativeImported
Gene namesi
ORF Names:PF11_0282Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1127100.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4222.

Interactioni

Protein-protein interaction databases

DIPiDIP-48435N.

Chemistry

BindingDBiQ8II92.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VYQX-ray2.40A/B/C1-173[»]
2Y8CX-ray2.10A/B/C1-173[»]
3T60X-ray2.40A/B/C1-173[»]
3T64X-ray1.65A/B/C1-173[»]
3T6YX-ray2.60A/B/C1-173[»]
3T70X-ray1.80A/B/C1-173[»]
ProteinModelPortaliQ8II92.
SMRiQ8II92. Positions 1-167.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8II92.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000028966.
InParanoidiQ8II92.
KOiK01520.
OMAiCEKSENK.
PhylomeDBiQ8II92.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8II92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLKIVCLSD EVREMYKNHK THHEGDSGLD LFIVKDEVLK PKSTTFVKLG
60 70 80 90 100
IKAIALQYKS NYYYKCEKSE NKKKDDDKSN IVNTSFLLFP RSSISKTPLR
110 120 130 140 150
LANSIGLIDA GYRGEIIAAL DNTSDQEYHI KKNDKLVQLV SFTGEPLSFE
160 170
LVEELDETSR GEGGFGSTSN NKY
Length:173
Mass (Da):19,573
Last modified:March 1, 2003 - v1
Checksum:i477D8A513AB0ACBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014840 Genomic DNA. Translation: AAN35866.1.
RefSeqiXP_001347953.1. XM_001347917.1.

Genome annotation databases

EnsemblProtistsiPF11_0282:mRNA; PF11_0282:pep; PF11_0282.
GeneDBiPF3D7_1127100.1:pep.
GeneIDi810829.
KEGGipfa:PF11_0282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014840 Genomic DNA. Translation: AAN35866.1.
RefSeqiXP_001347953.1. XM_001347917.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VYQX-ray2.40A/B/C1-173[»]
2Y8CX-ray2.10A/B/C1-173[»]
3T60X-ray2.40A/B/C1-173[»]
3T64X-ray1.65A/B/C1-173[»]
3T6YX-ray2.60A/B/C1-173[»]
3T70X-ray1.80A/B/C1-173[»]
ProteinModelPortaliQ8II92.
SMRiQ8II92. Positions 1-167.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48435N.

Chemistry

BindingDBiQ8II92.
ChEMBLiCHEMBL4222.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiPF11_0282:mRNA; PF11_0282:pep; PF11_0282.
GeneDBiPF3D7_1127100.1:pep.
GeneIDi810829.
KEGGipfa:PF11_0282.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1127100.

Phylogenomic databases

HOGENOMiHOG000028966.
InParanoidiQ8II92.
KOiK01520.
OMAiCEKSENK.
PhylomeDBiQ8II92.

Enzyme and pathway databases

BRENDAi3.6.1.23. 4889.

Miscellaneous databases

EvolutionaryTraceiQ8II92.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors."
    Whittingham J.L., Leal I., Nguyen C., Kasinathan G., Bell E., Jones A.F., Berry C., Benito A., Turkenburg J.P., Dodson E.J., Ruiz Perez L.M., Wilkinson A.J., Johansson N.G., Brun R., Gilbert I.H., Gonzalez Pacanowska D., Wilson K.S.
    Structure 13:329-338(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  4. Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS).

Entry informationi

Entry nameiQ8II92_PLAF7
AccessioniPrimary (citable) accession number: Q8II92
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: April 13, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.