Q8IFW9 (Q8IFW9_CIOIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alpha-(1,6)-fucosyltransferase PIRNR PIRNR000472
EC=2.4.1.68 PIRNR PIRNR000472

Gene names

Name:

FUT8 EMBL CAD56161.1

Organism

Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) EMBL CAD56161.1

Taxonomic identifier

7719 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Urochordata › Ascidiacea › Enterogona › Phlebobranchia › Cionidae › Ciona

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans By similarity. PIRNR PIRNR000472
Catalytic activity	GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine. PIRNR PIRNR000472
Pathway	Protein modification; protein glycosylation. PIRNR PIRNR000472
Subcellular location	Golgi apparatus › Golgi stack membrane By similarity PIRNR PIRNR000472.
Sequence similarities	Belongs to the glycosyltransferase 23 family. PIRNR PIRNR000472

Ontologies

Keywords
Cellular component	Golgi apparatus PIRNR PIRNR000472 Membrane PIRNR PIRNR000472
Molecular function	Glycosyltransferase PIRNR PIRNR000472 EMBL CAD56161.1 Transferase
Gene Ontology (GO)
Biological process	protein glycosylation in Golgi Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	glycoprotein 6-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IFW9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 85FC7F702EC58178	FASTA	512	59,217
	10 20 30 40 50 60 MRNSPCMFYC KIKESLKHGL KVRSLIRSVI VKSFQIQQLL NHDMNKLAEK NKDLVQRLVN 70 80 90 100 110 120 WDRLLVPLEN SLINEMTLLN NKDEEGDRYK LRELNRRAQH LIQHTQNQKN CRRAKKLFCN 130 140 150 160 170 180 VEAKCGFGCL VHHYGVCLFL AIGTNRVMQW DLKAITDYPG LDEVFMPLSE TCNNITGGKE 190 200 210 220 230 240 APEWYSEKSS NPTPVDTEVV KVTLIDSHDR QTPFAPMTIP EEFYPLVKPI HGDPLVWWAG 250 260 270 280 290 300 QVQSYLMRPK AWVTREVQII KQDIGFKHPV VGVHIRRTDK SNEANFQRME AYMDPVANWY 310 320 330 340 350 360 DKYVINNDVT NITKLVYVAT DDLEYMDMLR NLYPEFTFIT NQQSTSHADT SSRLSSDGLK 370 380 390 400 410 420 GIVTDVHLLV ECDHFVGTFS SNIGRLVYEM KQQYGSDPTF TTTNIDHAYR YWGQAIQLHK 430 440 450 460 470 480 AVMDHKPSLG FCKRAAPDMR QIDLSKMELM CEIEIKVGDI IEVSPESYHG YRSAGKNVRT 490 500 510 QMFGAYPLFK VKDIIKTAPY PSFYRTKSFE VE

References

[1]

"Splice variants of alpha-6-fucosyltransferase are expressed early in human embryogenesis." Mollicone R., Michalski J.C., Bauvy C., Cailleau-Thomas A., Candelier J.J., Martinez-Duncker I., Breton C., Codogno P., Oriol R. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ515151 mRNA. Translation: CAD56161.1.
RefSeq	NP_001128497.1. NM_001135025.1.
UniGene	Cin.29632.
3D structure databases
ProteinModelPortal	Q8IFW9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8IFW9.
Protein family/group databases
CAZy	GT23. Glycosyltransferase Family 23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100178043.
KEGG	cin:100178043.
Organism-specific databases
CTD	2530.
Phylogenomic databases
eggNOG	meNOG04143.
GeneTree	ENSGT00530000063737.
InParanoid	Q8IFW9.
Family and domain databases
InterPro	IPR015827. Alpha1_6FUT_euk. [Graphical view]
KO	K00717.
PIRSF	PIRSF000472. Alpha1_6FUT_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8IFW9_CIOIN

Accession

Primary (citable) accession number: Q8IFW9

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)