Q8IFW8 (Q8IFW8_CIOIN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alpha-(1,6)-fucosyltransferase PIRNR PIRNR000472
EC=2.4.1.68 PIRNR PIRNR000472

Gene names

Name:

FUT8 EMBL CAD56162.1

Organism

Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) EMBL CAD56162.1

Taxonomic identifier

7719 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Urochordata › Ascidiacea › Enterogona › Phlebobranchia › Cionidae › Ciona

Protein attributes

Sequence length	560 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans By similarity. PIRNR PIRNR000472
Catalytic activity	GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine. PIRNR PIRNR000472
Pathway	Protein modification; protein glycosylation. PIRNR PIRNR000472
Subcellular location	Golgi apparatus › Golgi stack membrane By similarity PIRNR PIRNR000472.
Sequence similarities	Belongs to the glycosyltransferase 23 family. PIRNR PIRNR000472

Ontologies

Keywords
Cellular component	Golgi apparatus PIRNR PIRNR000472 Membrane PIRNR PIRNR000472
Molecular function	Glycosyltransferase PIRNR PIRNR000472 EMBL CAD56162.1 Transferase
Gene Ontology (GO)
Biological process	protein glycosylation in Golgi Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi cisterna membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	glycoprotein 6-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8IFW8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: DEC70B7A0ECE6281	FASTA	560	65,066
	10 20 30 40 50 60 MRLRQFLHMD LRWRTFIVTF SIACCTFFYM FQITSRKSRV IVEGKFTKTE RWFHNNDAGE 70 80 90 100 110 120 SFDLQERQHI RNAMSDVEQI QAMVRHQLIK IYQESPKAQP LVIKMIKQFF PLKSALTAEI 130 140 150 160 170 180 EELKELTKQE DGELFKKLRK TVERRIDLNQ NPAKCSTAKK LYCNVQSACG FGCIIHHYTI 190 200 210 220 230 240 CLFISLGTGR VMMSNMSNLA YPNMDKIFLP LSRTCLTAEG NVDDYPEWES PNDEHPSSSD 250 260 270 280 290 300 APIVKVSIVY HRDRKTPFAP WTVPKDLIPS LERIHGNPML WWIGQLQSYL MRPQKWLSDS 310 320 330 340 350 360 IKEAKGEEFQ HPIVGVHVRR SDKISEASYM ANDAYMTAVS DWYDTYEMRH PNETVVRRIF 370 380 390 400 410 420 LATDDILIGS QLKITYPKYR IVQIQKNAVV ALAKRFSGSG LEGILQDVFL MAECDYFVGT 430 440 450 460 470 480 MSSNVGRLVH ELMQTRDYDT SNAAITIDHS FRYYGQFPER HLVLNDHHAE NPCPPEFEPL 490 500 510 520 530 540 PPNQFPKYVR ERLQLENILK QGCEVELRKG DIIDAWPELN NNYMRGGVNI RSGRWGLYPK 550 560 FKVKQIIEPA PYPVIENTSL

References

[1]

"Splice variants of alpha-6-fucosyltransferase are expressed early in human embryogenesis." Mollicone R., Michalski J.C., Bauvy C., Cailleau-Thomas A., Candelier J.J., Martinez-Duncker I., Breton C., Codogno P., Oriol R. Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ515152 mRNA. Translation: CAD56162.1.
RefSeq	NP_001128499.1. NM_001135027.1.
UniGene	Cin.22758.
3D structure databases
ProteinModelPortal	Q8IFW8.
ModBase	Search...
Protein family/group databases
CAZy	GT23. Glycosyltransferase Family 23.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100181649.
KEGG	cin:100181649.
Phylogenomic databases
eggNOG	meNOG04143.
Family and domain databases
InterPro	IPR015827. Alpha1_6FUT_euk. [Graphical view]
KO	K00717.
PIRSF	PIRSF000472. Alpha1_6FUT_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8IFW8_CIOIN

Accession

Primary (citable) accession number: Q8IFW8

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)