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Protein
Submitted name:

Eukaryotic initiation factor 4A-III, putative

Gene

PF3D7_0422700

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GeneDB
  • translation initiation factor activity Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase, Initiation factorImported
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic initiation factor 4A-III, putativeImported (EC:3.6.4.13Imported)
Gene namesi
ORF Names:PF3D7_0422700Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_0422700.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: GO_Central
  • cytoplasm Source: GO_Central
  • eukaryotic translation initiation factor 4F complex Source: GeneDB
  • nucleolus Source: GO_Central

Structurei

3D structure databases

ProteinModelPortaliQ8IFN9.
SMRiQ8IFN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 45Q_MOTIFInterPro annotationAdd BLAST29
Domaini48 – 218Helicase ATP-bindingInterPro annotationAdd BLAST171
Domaini229 – 390Helicase C-terminalInterPro annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi17 – 45Q motifPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000268797.
InParanoidiQ8IFN9.
KOiK13025.
OMAiDEMPVNA.
PhylomeDBiQ8IFN9.

Family and domain databases

CDDicd00079. HELICc. 1 hit.
InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IFN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKDDHYKTS EKYEICTSFE NIGIDEGLLR GIYAYGFEKP SAIQQRGIKP
60 70 80 90 100
ILNGRDVILQ SQSGTGKTCV FAVGALNCVN RNLNETQVII LSPTRELAEQ
110 120 130 140 150
TQKVCLALAD YIHVTIYCCI GGKKMSDDIK ALNNGVHVIS GTPGRIYHML
160 170 180 190 200
NLRHLKCKYI KQLVIDEADE MLNKGFKEQV YDIYRFLSPN TQIILSSATL
210 220 230 240 250
PQEVLEITNK FMHKPVKILV KRDELTLEGI KQFFVSIEKE QWKYETLADL
260 270 280 290 300
YESLTITQAV VFCNTQMKVD WLTKKMLESN FTVCKMHAGM SQSERDDIML
310 320 330 340 350
KFRQCKFRVL ISTDIWGRGL DVQEVSLVVN YDLPNSRESY IHRIGRSGRF
360 370 380 390
GRKGVAINFV KNDDIKILRD IEQYYSTQID EMPMNITELL
Length:390
Mass (Da):44,800
Last modified:March 1, 2003 - v1
Checksum:i7A527348A7CBC5CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844503 Genomic DNA. Translation: CAD49261.1.
RefSeqiXP_001351530.1. XM_001351494.1.

Genome annotation databases

EnsemblProtistsiCAD49261; CAD49261; PF3D7_0422700.
GeneDBiPF3D7_0422700.1:pep.
GeneIDi812458.
KEGGipfa:PFD1070w.

Similar proteinsi

Entry informationi

Entry nameiQ8IFN9_PLAF7
AccessioniPrimary (citable) accession number: Q8IFN9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported