Q8IEV4 (Q8IEV4_TRIVA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Thioredoxin PIRNR PIRNR000077

Gene names

Name:	trx EMBL CAD47836.1
ORF Names:	TVAG_125500 EMBL EAX98406.1

Organism

Trichomonas vaginalis [Reference proteome] EMBL CAD47836.1

Taxonomic identifier

5722 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Parabasalia › Trichomonadida › Trichomonadidae › Trichomonas

Protein attributes

Sequence length	112 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the thioredoxin family. PIRNR PIRNR000077 Contains 1 thioredoxin domain. RuleBase RU004207

Ontologies

Keywords
Technical term	3D-structure PDB 2F51 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro glycerol ether metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Disulfide bond	35 ↔ 38		Redox-active By similarity PIRSR PIRSR000077-4

Sequences

	Sequence		Length	Mass (Da)
	Q8IEV4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 4BA75628143470EB	FASTA	112	12,265
	10 20 30 40 50 60 MSDPIVHFNG THEALLNRIK EAPGLVLVDF FATWCGPCQR LGQILPSIAE ANKDVTFIKV 70 80 90 100 110 DVDKNGNAAD AYGVSSIPAL FFVKKEGNEI KTLDQFVGAD VSRIKADIEK FK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system." Coombs G.H., Westrop G.D., Suchan P., Puzova G., Hirt R.P., Embley T.M., Mottram J.C., Muller S. J. Biol. Chem. 279:5249-5256(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: G3 EMBL CAD47836.1.
[2]	"High-resolution structure of recombinant Trichomonas vaginalis thioredoxin." Iulek J., Alphey M.S., Westrop G.D., Coombs G.H., Hunter W.N. Acta Crystallogr. D 62:216-220(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).
[3]	"Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis." Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J. , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J. Science 315:207-212(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC PRA-98 / G3.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ507830 mRNA. Translation: CAD47836.1.
DS113677 Genomic DNA. Translation: EAX98406.1.

RefSeq

XP_001311336.1. XM_001311335.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2F51	X-ray	1.90	A/B	1-112	[»]

SMR

Q8IEV4. Positions 2-112.

ModBase

Search...

Protein-protein interaction databases

STRING

5722.Q8IEV4.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

4756203.

KEGG

tva:TVAG_125500.

Organism-specific databases

EuPathDB

TrichDB:TVAG_125500.

Phylogenomic databases

eggNOG

COG0526.

KO

K03671.

Family and domain databases

Gene3D

3.40.30.10. 1 hit.

InterPro

IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]

PANTHER

PTHR10438. PTHR10438. 1 hit.

Pfam

PF00085. Thioredoxin. 1 hit.
[Graphical view]

PIRSF

PIRSF000077. Thioredoxin. 1 hit.

PRINTS

PR00421. THIOREDOXIN.

SUPFAM

SSF52833. Thiordxn-like_fd. 1 hit.

PROSITE

PS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8IEV4.

Entry information

Entry name

Q8IEV4_TRIVA

Accession

Primary (citable) accession number: Q8IEV4
Secondary accession number(s): A2F9M5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)