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Protein

DNA ligase

Gene

PF3D7_1304100

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: GeneDB
  • DNA binding Source: InterPro
  • DNA ligase (ATP) activity Source: GeneDB
  • magnesium ion binding Source: GeneDB
  • manganese ion binding Source: GeneDB

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-PFA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-PFA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:PF3D7_1304100Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1304100

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_501328870516 – 912DNA ligaseSequence analysisAdd BLAST897

Proteomic databases

PRIDEiQ8IES4

Structurei

3D structure databases

ProteinModelPortaliQ8IES4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini642 – 778DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOGENOMiHOG000036006
InParanoidiQ8IES4
KOiK10747
OMAiWIKYKRD
PhylomeDBiQ8IES4

Family and domain databases

Gene3Di1.10.3260.10, 2 hits
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8IES4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLILVVLI KMVVCKIINY VRSDYNFMLS FLRTRKIFSH KKIYFNFKVS
60 70 80 90 100
KNITKNSSSN SYSDILKCFS FPRKGTNDKT KENETFEKGE VKEEEEEKDK
110 120 130 140 150
NVKRKIINES SKNKRAKVKN ENDVIKKGSL FNCVVREDEK VNDLSSPKFN
160 170 180 190 200
PVHFNINDLY LSEKDKEKHK FKDSLLFTFL TNAFNQIEEL KGSGTGSKKN
210 220 230 240 250
VSIILSNIFR VLIYYSPNDL IPAVYITLNK VAPDYLNVEA GVGEALILKT
260 270 280 290 300
MSEAYSRTES SIKKDLQQIE DLGIIAENCS CKMRTIFPLP RLTIQSVFHE
310 320 330 340 350
LKSIPNLIGS NSQQKKREVI KKLLVSAKTS EAKYIVRFLQ QRLRIGVNSA
360 370 380 390 400
TVVQALSYAF ILTRPSIPDD IIKRGKEINE NLINGKLDGT NNLINKSNNK
410 420 430 440 450
TEEWLTQSGD RNCIKEENLN DELLSKDDIN KCENMDSLIN EIRIRNEKIN
460 470 480 490 500
KPNIFYNLIE KVGDTRLLPL FFKELKNIYC EENNDIDIFE CMEKSVKSAL
510 520 530 540 550
CELPNIEIII QNLLNGDDMN TLSKKCTVKT GIPVQPMLAK PTKGVQEVLD
560 570 580 590 600
RFNNVTFTCE YKYDGERAQI HYIDKDNIKI FSRNLETMTE KYPDVIQIIK
610 620 630 640 650
DQIGENVKEC IIDSEVVAYD IVNNKILPFQ VLTTRKRKDV DIENIKVKVC
660 670 680 690 700
LFPFDLICCN GIPVIKEPLA VRRKLLYSLL KSKDGVLSYA THSEMNNIED
710 720 730 740 750
IDMFLQDAIE NNCEGLMVKT LVENASYEPS RRSLNWLKVK KDYVEGLSDS
760 770 780 790 800
VDLVPIAGYY GKGKRSGVYG AFVLAAYNSE TENFQTVCKA GTGFSDEILS
810 820 830 840 850
TLYETLSEKI IPNKKSYYEV SDKLNPDVWF DAHYVWEVKA ADLSLSPVHT
860 870 880 890 900
AAIGIYADDK GIGLRFPRFL RLREDKNAEQ ATTTQQIVDF YEAQFSSNKN
910
KNIDYNDDTE SE
Length:912
Mass (Da):104,506
Last modified:March 1, 2003 - v1
Checksum:iFFC1EC4B2428DD77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA Translation: CAD52175.1
RefSeqiXP_001349768.1, XM_001349732.1

Genome annotation databases

EnsemblProtistsiCAD52175; CAD52175; PF3D7_1304100
GeneDBiPF3D7_1304100.1:pep
GeneIDi813777
KEGGipfa:MAL13P1.22

Similar proteinsi

Entry informationi

Entry nameiQ8IES4_PLAF7
AccessioniPrimary (citable) accession number: Q8IES4
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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