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Q8IES4

- Q8IES4_PLAF7

UniProt

Q8IES4 - Q8IES4_PLAF7

Protein

DNA ligase

Gene

PfLigI

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium ion binding Source: GeneDB_Pfalciparum
    3. DNA binding Source: InterPro
    4. DNA ligase (ATP) activity Source: GeneDB_Pfalciparum
    5. magnesium ion binding Source: GeneDB_Pfalciparum
    6. manganese ion binding Source: GeneDB_Pfalciparum

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:PfLigIImported
    ORF Names:MAL13P1.22Imported
    OrganismiPlasmodium falciparum (isolate 3D7)Imported
    Taxonomic identifieri36329 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
    ProteomesiUP000001450: Chromosome 13

    Organism-specific databases

    EuPathDBiPlasmoDB:PF3D7_1304100.

    Interactioni

    Protein-protein interaction databases

    STRINGi5833.MAL13P1.22-1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8IES4.
    SMRiQ8IES4. Positions 180-376, 496-894.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036006.
    KOiK10747.
    OMAiFQTVCKA.
    PhylomeDBiQ8IES4.

    Family and domain databases

    Gene3Di1.10.3260.10. 2 hits.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8IES4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFLILVVLI KMVVCKIINY VRSDYNFMLS FLRTRKIFSH KKIYFNFKVS    50
    KNITKNSSSN SYSDILKCFS FPRKGTNDKT KENETFEKGE VKEEEEEKDK 100
    NVKRKIINES SKNKRAKVKN ENDVIKKGSL FNCVVREDEK VNDLSSPKFN 150
    PVHFNINDLY LSEKDKEKHK FKDSLLFTFL TNAFNQIEEL KGSGTGSKKN 200
    VSIILSNIFR VLIYYSPNDL IPAVYITLNK VAPDYLNVEA GVGEALILKT 250
    MSEAYSRTES SIKKDLQQIE DLGIIAENCS CKMRTIFPLP RLTIQSVFHE 300
    LKSIPNLIGS NSQQKKREVI KKLLVSAKTS EAKYIVRFLQ QRLRIGVNSA 350
    TVVQALSYAF ILTRPSIPDD IIKRGKEINE NLINGKLDGT NNLINKSNNK 400
    TEEWLTQSGD RNCIKEENLN DELLSKDDIN KCENMDSLIN EIRIRNEKIN 450
    KPNIFYNLIE KVGDTRLLPL FFKELKNIYC EENNDIDIFE CMEKSVKSAL 500
    CELPNIEIII QNLLNGDDMN TLSKKCTVKT GIPVQPMLAK PTKGVQEVLD 550
    RFNNVTFTCE YKYDGERAQI HYIDKDNIKI FSRNLETMTE KYPDVIQIIK 600
    DQIGENVKEC IIDSEVVAYD IVNNKILPFQ VLTTRKRKDV DIENIKVKVC 650
    LFPFDLICCN GIPVIKEPLA VRRKLLYSLL KSKDGVLSYA THSEMNNIED 700
    IDMFLQDAIE NNCEGLMVKT LVENASYEPS RRSLNWLKVK KDYVEGLSDS 750
    VDLVPIAGYY GKGKRSGVYG AFVLAAYNSE TENFQTVCKA GTGFSDEILS 800
    TLYETLSEKI IPNKKSYYEV SDKLNPDVWF DAHYVWEVKA ADLSLSPVHT 850
    AAIGIYADDK GIGLRFPRFL RLREDKNAEQ ATTTQQIVDF YEAQFSSNKN 900
    KNIDYNDDTE SE 912
    Length:912
    Mass (Da):104,506
    Last modified:March 1, 2003 - v1
    Checksum:iFFC1EC4B2428DD77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844509 Genomic DNA. Translation: CAD52175.1.
    RefSeqiXP_001349768.1. XM_001349732.1.

    Genome annotation databases

    EnsemblProtistsiMAL13P1.22:mRNA; MAL13P1.22:pep; MAL13P1.22.
    GeneIDi813777.
    KEGGipfa:MAL13P1.22.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL844509 Genomic DNA. Translation: CAD52175.1 .
    RefSeqi XP_001349768.1. XM_001349732.1.

    3D structure databases

    ProteinModelPortali Q8IES4.
    SMRi Q8IES4. Positions 180-376, 496-894.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5833.MAL13P1.22-1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi MAL13P1.22:mRNA ; MAL13P1.22:pep ; MAL13P1.22 .
    GeneIDi 813777.
    KEGGi pfa:MAL13P1.22.

    Organism-specific databases

    EuPathDBi PlasmoDB:PF3D7_1304100.

    Phylogenomic databases

    HOGENOMi HOG000036006.
    KOi K10747.
    OMAi FQTVCKA.
    PhylomeDBi Q8IES4.

    Family and domain databases

    Gene3Di 1.10.3260.10. 2 hits.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.
    2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
      Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
      , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
      Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Isolate 3D7Imported.

    Entry informationi

    Entry nameiQ8IES4_PLAF7
    AccessioniPrimary (citable) accession number: Q8IES4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3