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Protein

DNA ligase

Gene

PfLigI

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium ion binding Source: GeneDB
  • DNA binding Source: InterPro
  • DNA ligase (ATP) activity Source: GeneDB
  • magnesium ion binding Source: GeneDB
  • manganese ion binding Source: GeneDB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotationImported)
Gene namesi
Name:PfLigIImported
ORF Names:MAL13P1.22Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1304100.

Structurei

3D structure databases

ProteinModelPortaliQ8IES4.
SMRiQ8IES4. Positions 180-376, 496-894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ8IES4.
KOiK10747.
OMAiFQTVCKA.
PhylomeDBiQ8IES4.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IES4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFLILVVLI KMVVCKIINY VRSDYNFMLS FLRTRKIFSH KKIYFNFKVS
60 70 80 90 100
KNITKNSSSN SYSDILKCFS FPRKGTNDKT KENETFEKGE VKEEEEEKDK
110 120 130 140 150
NVKRKIINES SKNKRAKVKN ENDVIKKGSL FNCVVREDEK VNDLSSPKFN
160 170 180 190 200
PVHFNINDLY LSEKDKEKHK FKDSLLFTFL TNAFNQIEEL KGSGTGSKKN
210 220 230 240 250
VSIILSNIFR VLIYYSPNDL IPAVYITLNK VAPDYLNVEA GVGEALILKT
260 270 280 290 300
MSEAYSRTES SIKKDLQQIE DLGIIAENCS CKMRTIFPLP RLTIQSVFHE
310 320 330 340 350
LKSIPNLIGS NSQQKKREVI KKLLVSAKTS EAKYIVRFLQ QRLRIGVNSA
360 370 380 390 400
TVVQALSYAF ILTRPSIPDD IIKRGKEINE NLINGKLDGT NNLINKSNNK
410 420 430 440 450
TEEWLTQSGD RNCIKEENLN DELLSKDDIN KCENMDSLIN EIRIRNEKIN
460 470 480 490 500
KPNIFYNLIE KVGDTRLLPL FFKELKNIYC EENNDIDIFE CMEKSVKSAL
510 520 530 540 550
CELPNIEIII QNLLNGDDMN TLSKKCTVKT GIPVQPMLAK PTKGVQEVLD
560 570 580 590 600
RFNNVTFTCE YKYDGERAQI HYIDKDNIKI FSRNLETMTE KYPDVIQIIK
610 620 630 640 650
DQIGENVKEC IIDSEVVAYD IVNNKILPFQ VLTTRKRKDV DIENIKVKVC
660 670 680 690 700
LFPFDLICCN GIPVIKEPLA VRRKLLYSLL KSKDGVLSYA THSEMNNIED
710 720 730 740 750
IDMFLQDAIE NNCEGLMVKT LVENASYEPS RRSLNWLKVK KDYVEGLSDS
760 770 780 790 800
VDLVPIAGYY GKGKRSGVYG AFVLAAYNSE TENFQTVCKA GTGFSDEILS
810 820 830 840 850
TLYETLSEKI IPNKKSYYEV SDKLNPDVWF DAHYVWEVKA ADLSLSPVHT
860 870 880 890 900
AAIGIYADDK GIGLRFPRFL RLREDKNAEQ ATTTQQIVDF YEAQFSSNKN
910
KNIDYNDDTE SE
Length:912
Mass (Da):104,506
Last modified:March 1, 2003 - v1
Checksum:iFFC1EC4B2428DD77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52175.1.
RefSeqiXP_001349768.1. XM_001349732.1.

Genome annotation databases

EnsemblProtistsiMAL13P1.22:mRNA; MAL13P1.22:pep; MAL13P1.22.
GeneIDi813777.
KEGGipfa:MAL13P1.22.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52175.1.
RefSeqiXP_001349768.1. XM_001349732.1.

3D structure databases

ProteinModelPortaliQ8IES4.
SMRiQ8IES4. Positions 180-376, 496-894.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiMAL13P1.22:mRNA; MAL13P1.22:pep; MAL13P1.22.
GeneIDi813777.
KEGGipfa:MAL13P1.22.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1304100.

Phylogenomic databases

HOGENOMiHOG000036006.
InParanoidiQ8IES4.
KOiK10747.
OMAiFQTVCKA.
PhylomeDBiQ8IES4.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.
  2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D., Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corto C., Cronin A., Davies R., Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D., Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7Imported.

Entry informationi

Entry nameiQ8IES4_PLAF7
AccessioniPrimary (citable) accession number: Q8IES4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.