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Q8IES4

- Q8IES4_PLAF7

UniProt

Q8IES4 - Q8IES4_PLAF7

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Protein
DNA ligase
Gene
PfLigI, MAL13P1.22
Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation Source: GeneDB_Pfalciparum
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. lagging strand elongation Source: GeneDB_Pfalciparum
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:PfLigIImported
ORF Names:MAL13P1.22Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)
ProteomesiUP000001450: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1304100.

Subcellular locationi

GO - Cellular componenti

  1. apicoplast Source: GeneDB_Pfalciparum
  2. replication fork Source: GeneDB_Pfalciparum
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi5833.MAL13P1.22-1.

Structurei

3D structure databases

ProteinModelPortaliQ8IES4.
SMRiQ8IES4. Positions 180-376, 496-894.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036006.
KOiK10747.
OMAiFQTVCKA.
PhylomeDBiQ8IES4.

Family and domain databases

Gene3Di1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IES4-1 [UniParc]FASTAAdd to Basket

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MNFLILVVLI KMVVCKIINY VRSDYNFMLS FLRTRKIFSH KKIYFNFKVS    50
KNITKNSSSN SYSDILKCFS FPRKGTNDKT KENETFEKGE VKEEEEEKDK 100
NVKRKIINES SKNKRAKVKN ENDVIKKGSL FNCVVREDEK VNDLSSPKFN 150
PVHFNINDLY LSEKDKEKHK FKDSLLFTFL TNAFNQIEEL KGSGTGSKKN 200
VSIILSNIFR VLIYYSPNDL IPAVYITLNK VAPDYLNVEA GVGEALILKT 250
MSEAYSRTES SIKKDLQQIE DLGIIAENCS CKMRTIFPLP RLTIQSVFHE 300
LKSIPNLIGS NSQQKKREVI KKLLVSAKTS EAKYIVRFLQ QRLRIGVNSA 350
TVVQALSYAF ILTRPSIPDD IIKRGKEINE NLINGKLDGT NNLINKSNNK 400
TEEWLTQSGD RNCIKEENLN DELLSKDDIN KCENMDSLIN EIRIRNEKIN 450
KPNIFYNLIE KVGDTRLLPL FFKELKNIYC EENNDIDIFE CMEKSVKSAL 500
CELPNIEIII QNLLNGDDMN TLSKKCTVKT GIPVQPMLAK PTKGVQEVLD 550
RFNNVTFTCE YKYDGERAQI HYIDKDNIKI FSRNLETMTE KYPDVIQIIK 600
DQIGENVKEC IIDSEVVAYD IVNNKILPFQ VLTTRKRKDV DIENIKVKVC 650
LFPFDLICCN GIPVIKEPLA VRRKLLYSLL KSKDGVLSYA THSEMNNIED 700
IDMFLQDAIE NNCEGLMVKT LVENASYEPS RRSLNWLKVK KDYVEGLSDS 750
VDLVPIAGYY GKGKRSGVYG AFVLAAYNSE TENFQTVCKA GTGFSDEILS 800
TLYETLSEKI IPNKKSYYEV SDKLNPDVWF DAHYVWEVKA ADLSLSPVHT 850
AAIGIYADDK GIGLRFPRFL RLREDKNAEQ ATTTQQIVDF YEAQFSSNKN 900
KNIDYNDDTE SE 912
Length:912
Mass (Da):104,506
Last modified:March 1, 2003 - v1
Checksum:iFFC1EC4B2428DD77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844509 Genomic DNA. Translation: CAD52175.1.
RefSeqiXP_001349768.1. XM_001349732.1.

Genome annotation databases

EnsemblProtistsiMAL13P1.22:mRNA; MAL13P1.22:pep; MAL13P1.22.
GeneIDi813777.
KEGGipfa:MAL13P1.22.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL844509 Genomic DNA. Translation: CAD52175.1 .
RefSeqi XP_001349768.1. XM_001349732.1.

3D structure databases

ProteinModelPortali Q8IES4.
SMRi Q8IES4. Positions 180-376, 496-894.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5833.MAL13P1.22-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi MAL13P1.22:mRNA ; MAL13P1.22:pep ; MAL13P1.22 .
GeneIDi 813777.
KEGGi pfa:MAL13P1.22.

Organism-specific databases

EuPathDBi PlasmoDB:PF3D7_1304100.

Phylogenomic databases

HOGENOMi HOG000036006.
KOi K10747.
OMAi FQTVCKA.
PhylomeDBi Q8IES4.

Family and domain databases

Gene3Di 1.10.3260.10. 2 hits.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.
  2. "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
    Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z.
    , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
    Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Isolate 3D7.

Entry informationi

Entry nameiQ8IES4_PLAF7
AccessioniPrimary (citable) accession number: Q8IES4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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