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Protein
Submitted name:

M1-family alanyl aminopeptidase

Gene

PF3D7_1311800

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi496Zinc; via tele nitrogenCombined sources1
Metal bindingi500Zinc; via tele nitrogenCombined sources1
Metal bindingi519ZincCombined sources1

GO - Molecular functioni

GO - Biological processi

  • peptide catabolic process Source: GO_Central
  • proteolysis Source: GeneDB

Keywordsi

Molecular functionAminopeptidaseImported, Hydrolase, Protease
LigandMetal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BRENDAi3.4.11.20. 4889.
ReactomeiR-PFA-2142691. Synthesis of Leukotrienes (LT) and Eoxins (EX).
R-PFA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
M1-family alanyl aminopeptidaseImported (EC:3.4.11.2Imported)
Gene namesi
ORF Names:PF3D7_1311800Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1311800.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 24HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • cytoplasm Source: GeneDB
  • food vacuole Source: GeneDB
  • integral component of membrane Source: UniProtKB-KW
  • microneme Source: GeneDB
  • nucleus Source: GeneDB

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1293312.

Interactioni

Protein-protein interaction databases

IntActiQ8IEK1. 4 interactors.
MINTiMINT-1606497.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ZQTX-ray1.98A196-1084[»]
ProteinModelPortaliQ8IEK1.
SMRiQ8IEK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini407 – 629Peptidase_M1InterPro annotationAdd BLAST223
Domaini650 – 743DUF3458InterPro annotationAdd BLAST94
Domaini748 – 1080DUF3458_CInterPro annotationAdd BLAST333

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000257670.
InParanoidiQ8IEK1.
KOiK13725.
OMAiFKRWYSQ.
PhylomeDBiQ8IEK1.

Family and domain databases

CDDicd09600. M1_APN_1. 1 hit.
Gene3Di1.25.50.10. 1 hit.
InterProiView protein in InterPro
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
IPR012779. Peptidase_M1_pepN.
IPR024601. Peptidase_M1_pepN_C.
IPR035414. Peptidase_M1_pepN_Ig-like.
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiView protein in Pfam
PF11940. DUF3458. 1 hit.
PF17432. DUF3458_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
PRINTSiPR00756. ALADIPTASE.
TIGRFAMsiTIGR02414. pepN_proteo. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IEK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTKGCAYK YIIFTVLILA NILYDNKKRC MIKKNLRISS CGIISRLLKS
60 70 80 90 100
NSNYNSFNKN YNFTSAISEL QFSNFWNLDI LQKDIFSNIH NNKNKPQSYI
110 120 130 140 150
IHKRLMSEKG DNNNNNHQNN NGNDNKKRLG SVVNNEENTC SDKRMKPFEE
160 170 180 190 200
GHGITQVDKM NNNSDHLQQN GVMNLNSNNV ENNNNNNSVV VKKNEPKIHY
210 220 230 240 250
RKDYKPSGFI INNVTLNINI HDNETIVRSV LDMDISKHNV GEDLVFDGVG
260 270 280 290 300
LKINEISINN KKLVEGEEYT YDNEFLTIFS KFVPKSKFAF SSEVIIHPET
310 320 330 340 350
NYALTGLYKS KNIIVSQCEA TGFRRITFFI DRPDMMAKYD VTVTADKEKY
360 370 380 390 400
PVLLSNGDKV NEFEIPGGRH GARFNDPHLK PCYLFAVVAG DLKHLSATYI
410 420 430 440 450
TKYTKKKVEL YVFSEEKYVS KLQWALECLK KSMAFDEDYF GLEYDLSRLN
460 470 480 490 500
LVAVSDFNVG AMENKGLNIF NANSLLASKK NSIDFSYARI LTVVGHEYFH
510 520 530 540 550
NYTGNRVTLR DWFQLTLKEG LTVHRENLFS EEMTKTVTTR LSHVDLLRSV
560 570 580 590 600
QFLEDSSPLS HPIRPESYVS MENFYTTTVY DKGSEVMRMY LTILGEEYYK
610 620 630 640 650
KGFDIYIKKN DGNTATCEDF NYAMEQAYKM KKADNSANLN QYLLWFSQSG
660 670 680 690 700
TPHVSFKYNY DAEKKQYSIH VNQYTKPDEN QKEKKPLFIP ISVGLINPEN
710 720 730 740 750
GKEMISQTTL ELTKESDTFV FNNIAVKPIP SLFRGFSAPV YIEDNLTDEE
760 770 780 790 800
RILLLKYDSD AFVRYNSCTN IYMKQILMNY NEFLKAKNEK LESFNLTPVN
810 820 830 840 850
AQFIDAIKYL LEDPHADAGF KSYIVSLPQD RYIINFVSNL DTDVLADTKE
860 870 880 890 900
YIYKQIGDKL NDVYYKMFKS LEAKADDLTY FNDESHVDFD QMNMRTLRNT
910 920 930 940 950
LLSLLSKAQY PNILNEIIEH SKSPYPSNWL TSLSVSAYFD KYFELYDKTY
960 970 980 990 1000
KLSKDDELLL QEWLKTVSRS DRKDIYEILK KLENEVLKDS KNPNDIRAVY
1010 1020 1030 1040 1050
LPFTNNLRRF HDISGKGYKL IAEVITKTDK FNPMVATQLC EPFKLWNKLD
1060 1070 1080
TKRQELMLNE MNTMLQEPNI SNNLKEYLLR LTNKL
Length:1,085
Mass (Da):126,062
Last modified:March 1, 2003 - v1
Checksum:i72AE30928D6BD550
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52253.1.
RefSeqiXP_001349846.1. XM_001349810.1.

Genome annotation databases

EnsemblProtistsiCAD52253; CAD52253; PF3D7_1311800.
GeneDBiPF3D7_1311800.1:pep.
GeneIDi813945.
KEGGipfa:MAL13P1.56.

Similar proteinsi

Entry informationi

Entry nameiQ8IEK1_PLAF7
AccessioniPrimary (citable) accession number: Q8IEK1
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported