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Protein
Submitted name:

General transcription factor IIH subunit 2

Gene

PF3D7_1314900

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 321C4-typeUniRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-PFA-6781823. Formation of TC-NER Pre-Incision Complex.
R-PFA-72086. mRNA Capping.
R-PFA-73776. RNA Polymerase II Promoter Escape.
R-PFA-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Submitted name:
General transcription factor IIH subunit 2Imported
Gene namesi
ORF Names:PF3D7_1314900Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1314900.

Subcellular locationi

GO - Cellular componenti

  • core TFIIH complex Source: InterPro
  • cytoplasm Source: GeneDB
  • holo TFIIH complex Source: GO_Central
  • nucleus Source: GeneDB

Structurei

3D structure databases

ProteinModelPortaliQ8IEG6.
SMRiQ8IEG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 261VWFAInterPro annotationAdd BLAST177
Domaini357 – 396RING-typeInterPro annotationAdd BLAST40

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri304 – 321C4-typeUniRule annotationAdd BLAST18

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000280848.
InParanoidiQ8IEG6.
KOiK03142.
OMAiDCDIFIH.
PhylomeDBiQ8IEG6.

Family and domain databases

CDDicd01453. vWA_transcription_factor_IIH_t. 1 hit.
Gene3Di3.30.40.10. 1 hit.
3.40.50.410. 1 hit.
InterProiView protein in InterPro
IPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR036465. vWFA_dom_sf.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
PANTHERiPTHR12695. PTHR12695. 1 hit.
PfamiView protein in Pfam
PF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiView protein in SMART
SM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiView protein in PROSITE
PS50234. VWFA. 1 hit.
PS50089. ZF_RING_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IEG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNPQNSENK VIFVEDVVRD FDENEIFEEI TGKFTWEQDV ERSWNLLVEN
60 70 80 90 100
NGVLQHVSQE NNENENKEKY RKNQGSSLRK GIFRHIIILF DMSSSMKERD
110 120 130 140 150
LKPDRINVAL ECVESFLKNF FFKNPVGHVG VVALKNSSAK LIQPFTSNVD
160 170 180 190 200
DILNSILKER TAGLQGSPSL EEGLQIAHDL LIDMPLYGTK EVLIMYGSIR
210 220 230 240 250
TCDKKNILNV LELLVKSNIY VNCISIAPEM HILKHICEKS NGFYKICSSK
260 270 280 290 300
NSLMNEINNN AETPLWMQGM EPQLIHICFP TKKKISTQIM CSCHGKLNTD
310 320 330 340 350
TYVCNFCNSY TCKIPSKCKV CGIHLISMHD LSHITNNLQG SPLFIEIKNE
360 370 380 390 400
QGNYKVCSSC NQQLYNKIYQ CTKCQHIFCL ECDIFIHEEL NQCPFCLIND

T
Length:401
Mass (Da):45,986
Last modified:March 1, 2003 - v1
Checksum:i879D34E8DD8BE71E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52293.1.
RefSeqiXP_001349885.1. XM_001349849.1.

Genome annotation databases

EnsemblProtistsiCAD52293; CAD52293; PF3D7_1314900.
GeneDBiPF3D7_1314900.1:pep.
GeneIDi813966.
KEGGipfa:MAL13P1.76.

Similar proteinsi

Entry informationi

Entry nameiQ8IEG6_PLAF7
AccessioniPrimary (citable) accession number: Q8IEG6
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported