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Q8IDR3 (MYOA_PLAF7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Myosin-A
Alternative name(s):
PfM-A
Gene names
ORF Names:PF13_0233
OrganismPlasmodium falciparum (isolate 3D7) [Reference proteome]
Taxonomic identifier36329 [NCBI]
Taxonomic lineageEukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania) ›

Protein attributes

Sequence length818 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Tightly associated with the plasma membrane By similarity.

Domain

This protein differs from the typical myosin heavy chain structure in having head and tail domains but no discernible neck domain.

Sequence similarities

Contains 1 myosin head-like domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   LigandATP-binding
Actin-binding
Nucleotide-binding
   Molecular functionMotor protein
Myosin
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmyosin complex

Inferred from electronic annotation. Source: UniProtKB-KW

pellicle

Inferred from direct assay PubMed 10749937. Source: GeneDB_Pfalciparum

plasma membrane

Inferred from direct assay PubMed 10749937. Source: GeneDB_Pfalciparum

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

actin binding

Inferred from direct assay PubMed 10749937. Source: GeneDB_Pfalciparum

motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 818818Myosin-A
PRO_0000123374

Regions

Domain1 – 772772Myosin head-like
Nucleotide binding191 – 1988ATP By similarity
Region661 – 67111Actin-binding Potential
Region773 – 81846Tail

Secondary structure

1 ... 818
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8IDR3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F397875C52B3B19E

FASTA81892,277
        10         20         30         40         50         60 
MAVTNEEIKT ASKIVRRVSN VEAFDKSGSV FKGYQIWTDI SPTIENDPNI MFVKCVVQQG 

        70         80         90        100        110        120 
SKKEKLTVVQ IDPPGTGTPY DIDPTHAWNC NSQVDPMSFG DIGLLNHTNI PCVLDFLKHR 

       130        140        150        160        170        180 
YLKNQIYTTA VPLIVAINPY KDLGNTTNEW IRRYRDTADH TKLPPHVFTC AREALSNLHG 

       190        200        210        220        230        240 
VNKSQTIIVS GESGAGKTEA TKQIMRYFAS SKSGNMDLRI QTAIMAANPV LEAFGNAKTI 

       250        260        270        280        290        300 
RNNNSSRFGR FMQLVISHEG GIRYGSVVAF LLEKSRIITQ DDNERSYHIF YQFLKGANST 

       310        320        330        340        350        360 
MKSKFGLKGV TEYKLLNPNS TEVSGVDDVK DFEEVIESLK NMELSESDIE VIFSIVAGIL 

       370        380        390        400        410        420 
TLGNVRLIEK QEAGLSDAAA IMDEDMGVFN KACELMYLDP ELIKREILIK VTVAGGTKIE 

       430        440        450        460        470        480 
GRWNKNDAEV LKSSLCKAMY EKLFLWIIRH LNSRIEPEGG FKTFMGMLDI FGFEVFKNNS 

       490        500        510        520        530        540 
LEQLFINITN EMLQKNFVDI VFERESKLYK DEGISTAELK YTSNKEVINV LCEKGKSVLS 

       550        560        570        580        590        600 
YLEDQCLAPG GTDEKFVSSC ATNLKENNKF TPAKVASNKN FIIQHTIGPI QYCAESFLLK 

       610        620        630        640        650        660 
NKDVLRGDLV EVIKDSPNPI VQQLFEGQVI EKGKIAKGSL IGSQFLNQLT SLMNLINSTE 

       670        680        690        700        710        720 
PHFIRCIKPN ENKKPLEWCE PKILIQLHAL SILEALVLRQ LGYSYRRTFE EFLYQYKFVD 

       730        740        750        760        770        780 
IAAAEDSSVE NQNKCVNILK LSGLSESMYK IGKSMVFLKQ EGAKILTKIQ REKLVEWENC 

       790        800        810 
VSVIEAAILK HKYKQKVNKN IPSLLRVQAH IRKKMVAQ

« Hide

References

[1]"Genome sequence of the human malaria parasite Plasmodium falciparum."
Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W., Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S. expand/collapse author list , Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.
Nature 419:498-511(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate 3D7.
[2]"Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13."
Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D., Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K., Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T., Christodoulou Z. expand/collapse author list , Clark L., Clark R., Corton C., Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R., Sulston J.E., Craig A., Newbold C., Barrell B.G.
Nature 419:527-531(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Isolate 3D7.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL844509 Genomic DNA. Translation: CAD52556.1.
RefSeqXP_001350147.1. XM_001350111.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AOMX-ray1.94T799-816[»]
ProteinModelPortalQ8IDR3.
ModBaseSearch...

Protein-protein interaction databases

IntActQ8IDR3. 4 interactions.
MINTMINT-1641388.
STRING5833.PF13_0233-1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsPF13_0233:mRNA; PF13_0233:pep; PF13_0233.
GeneID814200.
KEGGpfa:PF13_0233.

Organism-specific databases

EuPathDBPlasmoDB:PF3D7_1342600.

Phylogenomic databases

HOGENOMHOG000283325.
OMALANDAYR.
ProtClustDBPTZ00014.

Family and domain databases

InterProIPR001609. Myosin_head_motor_dom.
[Graphical view]
PfamPF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00242. MYSc. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMYOA_PLAF7
AccessionPrimary (citable) accession number: Q8IDR3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: March 1, 2003
Last modified: April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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