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Protein

Nucleoside diphosphate kinase

Gene

PF3D7_1366500

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

GO - Molecular functioni

  • ATP binding Source: GeneDB
  • magnesium ion binding Source: GeneDB
  • nucleoside diphosphate kinase activity Source: GeneDB

GO - Biological processi

  • CTP biosynthetic process Source: GeneDB
  • GTP biosynthetic process Source: GeneDB
  • UTP biosynthetic process Source: GeneDB
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-PFA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-PFA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Gene namesi
ORF Names:PF3D7_1366500Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1366500.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XIQX-ray3.05A/B/C/D/E/F1-149[»]
ProteinModelPortaliQ8ID43.
SMRiQ8ID43.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ID43.

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000224564.
InParanoidiQ8ID43.
KOiK00940.
OMAiMLSGPVC.
PhylomeDBiQ8ID43.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ID43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKSFIMIKP DGVQRGLVGT IIKRFEKKGY KLIAIKMLNP TEEILKEHYK
60 70 80 90 100
ELSDQPFFKN LVAYISKGPV VAMVWEGVDM VKQGRKLIGE TNPLTSNTGT
110 120 130 140
IRGDFCLEVS KNVIHGSDSV ASANKEINIW FKAEELTQWK HHMKEWICS
Length:149
Mass (Da):17,012
Last modified:March 1, 2003 - v1
Checksum:iF8886BB3B0E18DCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52785.1.
RefSeqiXP_001350376.1. XM_001350340.1.

Genome annotation databases

EnsemblProtistsiCAD52785; CAD52785; PF3D7_1366500.
PF13_0349:mRNA; PF13_0349:pep; PF13_0349.
GeneDBiPF3D7_1366500.1:pep.
GeneIDi814308.
KEGGipfa:PF13_0349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL844509 Genomic DNA. Translation: CAD52785.1.
RefSeqiXP_001350376.1. XM_001350340.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XIQX-ray3.05A/B/C/D/E/F1-149[»]
ProteinModelPortaliQ8ID43.
SMRiQ8ID43.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCAD52785; CAD52785; PF3D7_1366500.
PF13_0349:mRNA; PF13_0349:pep; PF13_0349.
GeneDBiPF3D7_1366500.1:pep.
GeneIDi814308.
KEGGipfa:PF13_0349.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1366500.

Phylogenomic databases

HOGENOMiHOG000224564.
InParanoidiQ8ID43.
KOiK00940.
OMAiMLSGPVC.
PhylomeDBiQ8ID43.

Enzyme and pathway databases

ReactomeiR-PFA-499943. Synthesis and interconversion of nucleotide di- and triphosphates.
R-PFA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiQ8ID43.

Family and domain databases

HAMAPiMF_00451. NDP_kinase. 1 hit.
InterProiIPR001564. Nucleoside_diP_kinase.
IPR023005. Nucleoside_diP_kinase_AS.
[Graphical view]
PfamiPF00334. NDK. 1 hit.
[Graphical view]
PRINTSiPR01243. NUCDPKINASE.
SMARTiSM00562. NDK. 1 hit.
[Graphical view]
PROSITEiPS00469. NDP_KINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8ID43_PLAF7
AccessioniPrimary (citable) accession number: Q8ID43
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.