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Protein

DNA (cytosine-5)-methyltransferase

Gene

dnmt1

Organism
Paracentrotus lividus (Common sea urchin)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1219UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri627 – 673CXXC-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

Keywordsi

Molecular functionDNA-bindingUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase
LigandS-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferaseUniRule annotation (EC:2.1.1.37UniRule annotation)
Gene namesi
Name:dnmt1Imported
OrganismiParacentrotus lividus (Common sea urchin)Imported
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8IAJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini627 – 673CXXC-typeInterPro annotationAdd BLAST47
Domaini744 – 872BAHInterPro annotationAdd BLAST129
Domaini968 – 1090BAHInterPro annotationAdd BLAST123

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili261 – 281Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri627 – 673CXXC-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

InterProiView protein in InterPro
IPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNMT1-like.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
PfamiView protein in Pfam
PF01426. BAH. 2 hits.
PF06464. DMAP_binding. 2 hits.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiView protein in SMART
SM00439. BAH. 2 hits.
SM01137. DMAP_binding. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiView protein in PROSITE
PS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8IAJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKTICDQV IPPNVRDRVQ ELDGDLNDGL ITEKGYVKKK SKILFEHLSP
60 70 80 90 100
DIQTKLKGLE DEVKDEELTE KGYLSKVQSI LAKFIETCSP VNGDSKEEAS
110 120 130 140 150
SNGKGDEKTE SAIANGSTSN GSNTNGSSGS SKANGHANGG HVESSSQEET
160 170 180 190 200
GTSQSEEEMD MDTPTSGKGS KKKKKKSKGS SGGGDAGKGR KRKVLGDDER
210 220 230 240 250
DGVEKKEGEK KDVEGEEGEE AKEESATPDA KTLRTSKRKR SPKVDAKQPS
260 270 280 290 300
IMSMFTKKPA KKEEEKMEES LSMEVDKKEM ENGDDGNQEE EEPSGPVGKR
310 320 330 340 350
IKKEEEEEEK AKDEPMSPSR DLRHKANQET AENKQPPLRC KECRQLLDDP
360 370 380 390 400
DLKIFPGDPE DAREEYITLT DPRLSLLTGD EGDAMSYDER LQHKITNFCV
410 420 430 440 450
YDKSTHICAF DRGMIEKNKE LYFSGYVKPI YDDNPSTEGG IPTKRIGPIN
460 470 480 490 500
EWYTTGFDGG HKALIGFSTA FAEYIVMSPS EEYKPFWTAV QEKIYMSKIL
510 520 530 540 550
IEFLQNNVDP VYEDLLTQVE TTVPPEGCNR FTEDSLLRHA QFVVEQVESY
560 570 580 590 600
DDAADRDEVL LITMPCMRDL IKLAGVTLGN RRAARKRAAV KKDKKPVFTM
610 620 630 640 650
ATVTPLVSHI FDAIFKDQIA DEMKAAASER KKRCGVCEIC QAPDCGKCTA
660 670 680 690 700
CKDMIKFGGS GKAKQACKDR RCPNMAIQEA DENDIDEMDN SSNKENKDEK
710 720 730 740 750
KAKKGRKLET PLKKKKRAKV TWLGDPIEVT EERAYYKAAM LDDEKIENGD
760 770 780 790 800
CVLIHPDDPT KPLFMARVIY MWQESQGEMM FHRQWFVYGS ETVLGETSDP
810 820 830 840 850
LEVFPIDECQ DTYLGSVNAK CTVISGAPSH DWSMIGGIDD PETDHVIKED
860 870 880 890 900
DGKTFFYQKW YDPELARFED YEVLMAPYDI PAHRFCSCCL NNERAQEKET
910 920 930 940 950
ARPGAKLEDQ DDSSKVLYSS CHYKGNEFQI GDGVYLLPEA FSFNIKQKIV
960 970 980 990 1000
TKKPVSKKDV DEDLYPENYR KSSEYVKGSN LECPEPFRVG KIISIYTTKS
1010 1020 1030 1040 1050
SSTVRLRVNK MYRPEDTHKG RTAAYQADLN VLYWSEEEAV TELEVVQGKC
1060 1070 1080 1090 1100
SVVCAEDLNV STTEYSAGGP HKFYFREAYD SERKCFEDPP SKSRSTRMKG
1110 1120 1130 1140 1150
KGKGKGKGKA KGKMAVEKEE EKESTETPFN KLKCLDVFAG CGGLSEGFHQ
1160 1170 1180 1190 1200
AGICESSWAI EKEEPAAQAY RLNNPGSTVF SDDCNELLRL VMQGEKTSRT
1210 1220 1230 1240 1250
GQKLPQKGDV ELLCGGPPCQ GFSGMNRFNS REYSKFKNSL ISSYLSYCDY
1260 1270 1280 1290 1300
YRPRFFLLEN VRNFVSYKKN MVLKLALRCL IRMGYQCTFG ILQAGQYGVP
1310 1320 1330 1340 1350
QTRRRAIILA AAPGEKLPFY PEPLHVFSTR ACSLSVMIGE KKIESNNQWC
1360 1370 1380 1390 1400
LSAPYRTITV RDSMSDLPTI NNGAQKLEIS YDGEPQSDFQ KKIRGKQYHL
1410 1420
QWPQLSAWRL RCVFRQKPRK IKRGQLLNQ
Length:1,429
Mass (Da):160,950
Last modified:March 1, 2003 - v1
Checksum:iB6A6BF49DBD1B4BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ495767
, AJ495845, AJ495846, AJ495847, AJ495848, AJ495849, AJ495850, AJ495851, AJ495852, AJ495853, AJ495854, AJ495855, AJ496187 Genomic DNA. Translation: CAD43080.2.

Similar proteinsi

Entry informationi

Entry nameiQ8IAJ3_PARLI
AccessioniPrimary (citable) accession number: Q8IAJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: December 20, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)