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Protein
Submitted name:

CaLPain family

Gene

clp-4

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Protein family/group databases

MEROPSiC02.A06.

Names & Taxonomyi

Protein namesi
Submitted name:
CaLPain familyImported
Gene namesi
Name:clp-4Imported
ORF Names:CELE_Y39A3CL.5Imported, Y39A3CL.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiY39A3CL.5a; CE33219; WBGene00000545; clp-4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiQ8IAA9.
PaxDbiQ8IAA9.
PeptideAtlasiQ8IAA9.

Expressioni

Gene expression databases

BgeeiWBGene00000545.
ExpressionAtlasiQ8IAA9. differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.Y39A3CL.5a.2.

Structurei

3D structure databases

ProteinModelPortaliQ8IAA9.
SMRiQ8IAA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini240 – 536Calpain catalyticInterPro annotationAdd BLAST297

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000020136.
InParanoidiQ8IAA9.
OMAiANIKEAQ.
OrthoDBiEOG091G049E.
PhylomeDBiQ8IAA9.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8IAA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANHAKLVDQ EIYRSPVDDF ELNYQEYLND DDDDKQEAPV AVSKAPKGKG
60 70 80 90 100
SNHGLGCRMK GLFDGFGGTD LKTIMRHLRR RRPKSGQALT NFMLSGNMEK
110 120 130 140 150
VVDQHVKDFV HHFGRINPEN GRIMGALRGN DFFNFGGLHN NLGNTGKVYL
160 170 180 190 200
DNLMKGKCGK KRKVHKFKPI VVEELDFGAP KPAVPATPKA PVAPVAPVIP
210 220 230 240 250
APAVTPQKPK VDEPTYADSV SDFGLDFETE REKCLRNKTL FEDPEFPATA
260 270 280 290 300
ASLYYRTPPR DRIIWKRPGE IIANPQLITQ GESRFDVKQG ALGDCWFLAA
310 320 330 340 350
LANITLYDAL FYRIVPPNQS FTENYAGIFH FQFWHYGKWV DVVVDDRLPT
360 370 380 390 400
VNNQLYYLHS ADNTEFWSAL VEKAYAKLHG GYENLDGGTT AEALEDFTGG
410 420 430 440 450
LTEYFDLRKS EKAAVLAALV KGMEMGSLFG CSIDADANIK EAQLRNGLVC
460 470 480 490 500
GHAYSITAIH SITYYGEDTT LLRLRNPWGN EKEWNGAWSD GSSEWSKIDE
510 520 530 540 550
ATKKQIDVQF ARDGEFWMSF EDFFSNFTQM EVCNLTAEIF DEIAEMTGVN
560 570 580 590 600
RATETVEEEH QWHEIMEDGE WSSKKGTAGG CNNNPSTYPK NPQFSTFFTA
610 620 630 640 650
PQSSIEADGN VTVIVAVLQK YRRELRSKGK DVLPIGVSIY SLGAEGTARS
660 670 680 690 700
PLTAQFFSQN RPIARTTVFV NTREVTVRFR VPPGQYVIVP CTFDAYDDAE
710
FLLRVYANGT LKSSLL
Length:716
Mass (Da):80,262
Last modified:March 1, 2003 - v1
Checksum:i7D38A9B59BC20C36
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD73776.1.
RefSeqiNP_497460.2. NM_065059.7.
UniGeneiCel.9832.

Genome annotation databases

EnsemblMetazoaiY39A3CL.5a; Y39A3CL.5a; WBGene00000545.
GeneIDi175326.
KEGGicel:CELE_Y39A3CL.5.
UCSCiY39A3CL.5a. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA. Translation: CCD73776.1.
RefSeqiNP_497460.2. NM_065059.7.
UniGeneiCel.9832.

3D structure databases

ProteinModelPortaliQ8IAA9.
SMRiQ8IAA9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.Y39A3CL.5a.2.

Protein family/group databases

MEROPSiC02.A06.

Proteomic databases

EPDiQ8IAA9.
PaxDbiQ8IAA9.
PeptideAtlasiQ8IAA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY39A3CL.5a; Y39A3CL.5a; WBGene00000545.
GeneIDi175326.
KEGGicel:CELE_Y39A3CL.5.
UCSCiY39A3CL.5a. c. elegans.

Organism-specific databases

CTDi175326.
WormBaseiY39A3CL.5a; CE33219; WBGene00000545; clp-4.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000020136.
InParanoidiQ8IAA9.
OMAiANIKEAQ.
OrthoDBiEOG091G049E.
PhylomeDBiQ8IAA9.

Gene expression databases

BgeeiWBGene00000545.
ExpressionAtlasiQ8IAA9. differential.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8IAA9_CAEEL
AccessioniPrimary (citable) accession number: Q8IAA9
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.