ID   MT4_DROME               Reviewed;          44 AA.
AC   Q8I9B4; Q1WW94; Q86B88;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 88.
DE   RecName: Full=Metallothionein-4;
DE            Short=MT-4;
DE   AltName: Full=Metallothionein D;
GN   Name=MtnD; ORFNames=CG33192;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Canton-S;
RX   PubMed=12505988; DOI=10.1093/emboj/cdg012;
RA   Egli D., Selvaraj A., Yepiskoposyan H., Zhang B., Hafen E., Georgiev O.,
RA   Schaffner W.;
RT   "Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by
RT   homologous recombination reveals its central role in heavy metal
RT   homeostasis.";
RL   EMBO J. 22:100-108(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA   Park S., Wan K.H., Yu C., Celniker S.E.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This protein binds cations of several transition elements.
CC       Thought to be involved in metal ion homeostasis (By similarity).
CC       {ECO:0000250}.
CC   -!- DOMAIN: All cysteine residues are arranged in C-X-C groups. These are
CC       thought to be the metal-binding sites in other metallothioneins.
CC   -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 5 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABE01242.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF546903; AAN73050.1; -; mRNA.
DR   EMBL; AE014297; AAO41579.2; -; Genomic_DNA.
DR   EMBL; BT025012; ABE01242.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_788695.2; NM_176518.2.
DR   AlphaFoldDB; Q8I9B4; -.
DR   IntAct; Q8I9B4; 2.
DR   STRING; 7227.FBpp0300409; -.
DR   PaxDb; 7227-FBpp0300409; -.
DR   DNASU; 326270; -.
DR   EnsemblMetazoa; FBtr0308064; FBpp0300409; FBgn0053192.
DR   GeneID; 326270; -.
DR   KEGG; dme:Dmel_CG33192; -.
DR   AGR; FB:FBgn0053192; -.
DR   CTD; 326270; -.
DR   FlyBase; FBgn0053192; MtnD.
DR   VEuPathDB; VectorBase:FBgn0053192; -.
DR   eggNOG; KOG4738; Eukaryota.
DR   HOGENOM; CLU_217426_0_0_1; -.
DR   InParanoid; Q8I9B4; -.
DR   PhylomeDB; Q8I9B4; -.
DR   BioGRID-ORCS; 326270; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 326270; -.
DR   PRO; PR:Q8I9B4; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0053192; Expressed in midgut and 19 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IDA:FlyBase.
DR   GO; GO:0140961; P:cellular detoxification of metal ion; IMP:FlyBase.
DR   GO; GO:0046688; P:response to copper ion; IDA:FlyBase.
DR   GO; GO:0010038; P:response to metal ion; IDA:FlyBase.
DR   InterPro; IPR000966; Metalthion_5.
DR   Pfam; PF02067; Metallothio_5; 1.
DR   PRINTS; PR00872; MTDIPTERA.
DR   Genevisible; Q8I9B4; DM.
PE   3: Inferred from homology;
KW   Cadmium; Copper; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..44
FT                   /note="Metallothionein-4"
FT                   /id="PRO_0000197357"
SQ   SEQUENCE   44 AA;  4545 MW;  34F0847BFA8BCC7B CRC64;
     MGCKACGTNC QCSATKCGDN CACSQQCQCS CKNGPKDKCC STKN
//